Eleanor Stride

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Eleanor Stride
Alma mater University College London
Awards Institution of Engineering and Technology Harvey Prize (2015) Philip Leverhulme Prize (2009)
Scientific career
Institutions University College London
University of Oxford
Doctoral advisor Nader Saffari

Eleanor Phoebe Jane Stride OBE FREng is a Professor of Biomaterials at St Catherine's College, Oxford. Stride engineers drug delivery systems using carefully designed microbubbles and studies how they can be used in diagnostics.

Contents

Education

Stride completed her Bachelor's degree in Mechanical Engineering and a PhD in the Ultrasonics group at University College London. [1] [2] She had planned to work for Aston Martin. [3] Whilst there became interested in using ultrasound for imaging microbubbles, and was awarded a Royal Society Brian Mercer Innovation Feasibility Award. [1] [4] [5]

Research and career

Stride was awarded a Royal Academy of Engineering lectureship at University College London, where she explored ultrasound for drug delivery. [6] Microbubbles in the bloodstream created a strong ultrasound echo, which allows doctors to trace where the blood is flowing. [7] Whilst at University College London she collaborated with the Wellcome Collection. [8] She was awarded an Engineering and Physical Sciences Research Council Challenging Engineering Award in 2011. [9] That year she joined the Oxford Institute of Biomedical Engineering in 2011. [10] She is a Fellow at St Catherine's College, Oxford. [11] The award allowed her to develop new agents for targeted drug delivery, which allowed clinicians more control in transporting and releasing medical therapeutics. [9] Stride encapsulates deactivated drugs in 'carriers' which can be navigated around the body to a target. [6] She also explored how her novel agents interacted with cells and tissue. [9] Her research could be used to deliver chemotherapy. [12] She has several patents for the creation and imaging of microbubbles. [13] [14] She created the spin-out company AtoCap. [15] [16] AtoCap focussed on the treatment of chronic infections. [17]

Stride was appointed full Professor in 2014. [10] By using custom-designed magnetic arrays, the Stride group have managed to trap particles in tissue several centimetres deep. [18] She demonstrated that it is possible to load oxygen into microbubbles to improve Sonodynamic therapy. [19] [20] She was made a Fellow of the Royal Academy of Engineering in 2017. [21]

Public engagement and diversity

In 2016 Stride was named one of the Top 50 Influential Women in Engineering. [10] [22] [23] She has appeared on BBC Radio 4. [24] [25] She features on a number of YouTube videos with the Royal Institution. [26] She created a revision series with BBC bitesize. [27]

Awards

Stride was appointed Officer of the Order of the British Empire (OBE) in the 2021 New Year Honours for services to engineering. [32]

Related Research Articles

The Engineering and Physical Sciences Research Council (EPSRC) is a British Research Council that provides government funding for grants to undertake research and postgraduate degrees in engineering and the physical sciences, mainly to universities in the United Kingdom. EPSRC research areas include mathematics, physics, chemistry, artificial intelligence and computer science, but exclude particle physics, nuclear physics, space science and astronomy. Since 2018 it has been part of UK Research and Innovation, which is funded through the Department for Business, Energy and Industrial Strategy.

<span class="mw-page-title-main">Contrast-enhanced ultrasound</span>

Contrast-enhanced ultrasound (CEUS) is the application of ultrasound contrast medium to traditional medical sonography. Ultrasound contrast agents rely on the different ways in which sound waves are reflected from interfaces between substances. This may be the surface of a small air bubble or a more complex structure. Commercially available contrast media are gas-filled microbubbles that are administered intravenously to the systemic circulation. Microbubbles have a high degree of echogenicity. There is a great difference in echogenicity between the gas in the microbubbles and the soft tissue surroundings of the body. Thus, ultrasonic imaging using microbubble contrast agents enhances the ultrasound backscatter, (reflection) of the ultrasound waves, to produce a sonogram with increased contrast due to the high echogenicity difference. Contrast-enhanced ultrasound can be used to image blood perfusion in organs, measure blood flow rate in the heart and other organs, and for other applications.

<span class="mw-page-title-main">Department of Engineering Science, University of Oxford</span> University department in Oxford, England

The Department of Engineering Science is the engineering department of the University of Oxford. It is part of the university's Mathematical, Physical and Life Sciences Division. The department was ranked 3rd best institute in the UK for engineering in the 2021 Research Excellence Framework.

<span class="mw-page-title-main">Perfluoropentane</span> Chemical compound

Perfluoropentane (PFP) or dodecafluoropentane; also known as Perflenapent (INN/USAN) is a fluorocarbon, the fluorinated analogue of pentane. It is a liquid that boils at slightly over room temperature.

<span class="mw-page-title-main">Sonoporation</span> Technique in molecular biology

Sonoporation, or cellular sonication, is the use of sound in the ultrasonic range for increasing the permeability of the cell plasma membrane. This technique is usually used in molecular biology and non-viral gene therapy in order to allow uptake of large molecules such as DNA into the cell, in a cell disruption process called transfection or transformation. Sonoporation employs the acoustic cavitation of microbubbles to enhance delivery of these large molecules. The exact mechanism of sonoporation-mediated membrane translocation remains unclear, with a few different hypotheses currently being explored.

Microbubbles are bubbles smaller than one hundredth of a millimetre in diameter, but larger than one micrometre. They have widespread application in industry, medicine, life science, and food technology. The composition of the bubble shell and filling material determine important design features such as buoyancy, crush strength, thermal conductivity, and acoustic properties.

Nick Rhodes is a Reader in Tissue Engineering and Regenerative Medicine at the University of Liverpool, in the U.K. Tissue Engineering can be described as the use of engineering techniques, including engineering materials and processes, in order to grow living tissues. Regenerative Medicine can be described as the treatment of defective tissues using the regenerative capacity of the body's healthy tissues. Rhodes describes the discipline as "aiming to repair tissue defects by driving regeneration of healthy tissues using engineered materials and processes."

<span class="mw-page-title-main">Sonodynamic therapy</span>

Sonodynamic therapy (SDT) is a noninvasive treatment, often used for tumor irradiation, that utilizes a sonosensitizer and the deep penetration of ultrasound to treat lesions of varying depths by reducing target cell number and preventing future tumor growth. Many existing cancer treatment strategies cause systemic toxicity or cannot penetrate tissue deep enough to reach the entire tumor; however, emerging ultrasound stimulated therapies could offer an alternative to these treatments with their increased efficiency, greater penetration depth, and reduced side effects. Sonodynamic therapy could be used to treat cancers and other diseases, such as atherosclerosis, and diminish the risk associated with other treatment strategies since it induces cytotoxic effects only when externally stimulated by ultrasound and only at the cancerous region, as opposed to the systemic administration of chemotherapy drugs.

Naomi Wendy Climer, is a British engineer who has worked in broadcast, media and communications technology chiefly at the BBC and Sony Professional Solutions, and was the first female President of the Institution of Engineering and Technology (IET). Climer is the co-founder and co-chair of the Institute for the Future of Work.

<span class="mw-page-title-main">Anne Neville (engineer)</span> British academic (1970–2022)

Anne Neville was the Royal Academy of Engineering Chair in emerging technologies and Professor of Tribology and Surface Engineering at the University of Leeds.

<span class="mw-page-title-main">Alison Noble</span> British engineer (born 1965)

Julia Alison Noble is a British engineer. She has been Technikos Professor of Biomedical Engineering at the University of Oxford and a fellow of St Hilda's College since 2011, and Associate Head of the Mathematical, Physical and Life Sciences Division at the university. As of 2017, she is the chief technology officer of Intelligent Ultrasound Limited, an Oxford spin-off in medical imaging that she cofounded. She was director of the Oxford Institute of Biomedical Engineering (IBME) from 2012 to 2016.In 2023 she became the Foreign Secretary of The Royal Society.

<span class="mw-page-title-main">Charlotte Deane</span> Professor of Structural Bioinformatics

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<span class="mw-page-title-main">Jane Jiang</span>

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Claire Sandrine Jacqueline Adjiman is a professor of Chemical Engineering at the Department of Chemical Engineering at Imperial College London and a Fellow of the Royal Academy of Engineering.

<span class="mw-page-title-main">Ijeoma Uchegbu</span> Nigerian-British pharmacist and Professor of Pharmacy

Ijeoma Uchegbu is a Nigerian-British Professor of Pharmacy at University College London where she held the position of Pro-Vice Provost for Africa and the Middle East. She is the Chief Scientific Officer of Nanomerics, a pharmaceutical nanotechnology company specialising in drug delivery solutions for poorly water-soluble drugs, nucleic acids and peptides. She is also a Governor of the Wellcome, a large biomedical research charity. Apart from her highly cited scientific research in Pharmaceutical Nanoscience, Uchegbu is also known for her work in science public engagement and equality and diversity in Science, Technology, Engineering and Mathematics (STEM).

<span class="mw-page-title-main">Máire O'Neill</span> Northern Irish academic (engineering, information security)

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<span class="mw-page-title-main">Focused ultrasound for intracranial drug delivery</span> Medical technique

Focused ultrasound for intracrainial drug delivery is a non-invasive technique that uses high-frequency sound waves to disrupt tight junctions in the blood–brain barrier (BBB), allowing for increased passage of therapeutics into the brain. The BBB normally blocks nearly 98% of drugs from accessing the central nervous system, so FUS has the potential to address a major challenge in intracranial drug delivery by providing targeted and reversible BBB disruption. Using FUS to enhance drug delivery to the brain could significantly improve patient outcomes for a variety of diseases including Alzheimer's disease, Parkinson's disease, and brain cancer.

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References

  1. 1 2 3 4 5 6 7 "Professor Eleanor Stride — Institute of Biomedical Engineering". www.ibme.ox.ac.uk. Retrieved 3 July 2018.
  2. ↑ UCL (15 March 2010), Mini-lecture: The science of microbubbles (UCL) , retrieved 3 July 2018
  3. ↑ HAVAS LYNX (20 June 2018), Episode 5: #LXAcademy Launch 2018, Professor Eleanor Stride - A Completely New Angle , retrieved 3 July 2018
  4. ↑ Stride, E.; Saffari, N. (2005). "Investigating the significance of multiple scattering in ultrasound contrast agent particle populations - IEEE Journals & Magazine" (PDF). IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 52 (12): 2332–45. doi:10.1109/TUFFC.2005.1563278. PMID   16463501. S2CID   26846678.
  5. ↑ "International Day of Women and Girls in Science". Oxford University. 9 February 2018. Retrieved 3 July 2018.
  6. 1 2 "Interview: Eleanor Stride IET A F Harvey prize winner". 3 February 2015. Retrieved 3 July 2018.
  7. ↑ "Top Universities | Video Search Site". www.universityvideos.org. Retrieved 3 July 2018.
  8. ↑ "Eating, walking, stretching and bubbles". Wellcome Collection. Retrieved 3 July 2018.
  9. 1 2 3 "Dr Eleanor Stride, University College London - EPSRC website". epsrc.ukri.org. Retrieved 3 July 2018.
  10. 1 2 3 "Eleanor Stride | www.oxfordsparks.ox.ac.uk". www.oxfordsparks.ox.ac.uk. Retrieved 3 July 2018.
  11. ↑ "Why haven't we cured cancer? - IET Events". events.theiet.org. Retrieved 3 July 2018.
  12. ↑ "Dr Eleanor Stride — ERA Foundation". ERA Foundation. 26 November 2014. Retrieved 3 July 2018.
  13. ↑ Method and apparatus for generating bubbles, issue-date: 2017-01-20, retrieved 3 July 2018
  14. ↑ Beverage composition comprising nanoencapsulated oxygen, issue-date: 2016, retrieved 3 July 2018
  15. ↑ "Meet The Team - Atocap". Meet The Team - Atocap. Retrieved 3 July 2018.
  16. ↑ "Eleanor Stride — Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences". www.ndorms.ox.ac.uk. Retrieved 3 July 2018.
  17. ↑ Labbaf, Sheyda; Horsley, Harry; Chang, Ming-Wei; Stride, Eleanor; Malone-Lee, James; Edirisinghe, Mohan; Rohn, Jennifer L. (6 December 2013). "An encapsulated drug delivery system for recalcitrant urinary tract infection". Journal of the Royal Society Interface. 10 (89): 20130747. doi:10.1098/rsif.2013.0747. ISSN   1742-5689. PMC   3808553 . PMID   24068180.
  18. ↑ Barnsley, Lester C.; Carugo, Dario; Owen, Joshua; Stride, Eleanor (7 November 2015). "Halbach arrays consisting of cubic elements optimised for high field gradients in magnetic drug targeting applications". Physics in Medicine and Biology. 60 (21): 8303–8327. Bibcode:2015PMB....60.8303B. doi:10.1088/0031-9155/60/21/8303. ISSN   1361-6560. PMID   26458056. S2CID   29807333.
  19. ↑ McEwan, Conor; Owen, Joshua; Stride, Eleanor; Fowley, Colin; Nesbitt, Heather; Cochrane, David; Coussios, Constantin C.; Borden, M.; Nomikou, Nikolitsa (10 April 2015). "Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours". Journal of Controlled Release. 203: 51–56. doi:10.1016/j.jconrel.2015.02.004. ISSN   1873-4995. PMID   25660073.
  20. ↑ McEwan, Conor; Kamila, Sukanta; Owen, Joshua; Nesbitt, Heather; Callan, Bridgeen; Borden, Mark; Nomikou, Nikolitsa; Hamoudi, Rifat A.; Taylor, Mark A. (February 2016). "Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle". Biomaterials. 80: 20–32. doi:10.1016/j.biomaterials.2015.11.033. ISSN   1878-5905. PMID   26702983.
  21. 1 2 "Professor of Engineering Science, University of Oxford". Royal Academy of Engineering. Retrieved 3 June 2018.
  22. ↑ "June 2016 - Professor Eleanor Stride makes top 50 Women in Engineering List — Institute of Biomedical Engineering". www.ibme.ox.ac.uk. Retrieved 3 July 2018.
  23. ↑ "Professor Eleanor Stride named as one of the top 50 women in Engineering | www.stcatz.ox.ac.uk". www.stcatz.ox.ac.uk. Retrieved 3 July 2018.
  24. ↑ "Nano-bubbles and drug delivery, The Imagineers - BBC Two". BBC. Retrieved 3 July 2018.
  25. ↑ "Woman's Hour - Five things we learnt about women in engineering from Professor Dame Ann Dowling - BBC Radio 4". BBC. Retrieved 3 July 2018.
  26. ↑ The Royal Institution (15 April 2014), Born to Engineer - Biomedical bubbles with Eleanor Stride , retrieved 3 July 2018
  27. ↑ "BBC Bitesize - Higher Engineering science - Nano-bubbles and drug delivery". BBC Bitesize. Retrieved 3 July 2018.
  28. ↑ "The promise of microbubbles". www.ucl.ac.uk. 16 March 2010. Retrieved 3 July 2018.
  29. ↑ "Acoustical Society of America Awards - Acoustical Society of America". Acoustical Society of America. Retrieved 3 July 2018.
  30. ↑ "Dr Eleanor Stride receives 2013 R. Bruce Lindsay Award of the Acoustical Society of America — Department of Engineering Science". www.eng.ox.ac.uk. Retrieved 3 July 2018.
  31. ↑ IET (25 February 2015), Professor Eleanor Stride: 2014 IET A.F. Harvey Prize Winner , retrieved 3 July 2018
  32. ↑ "No. 63218". The London Gazette (Supplement). 31 December 2020. p. N14.
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