Elion-Hitchings Building

Last updated
Elion-Hitchings Building
Elionhitchingsbuilding2020 1.jpg
Taken 11/29/2020
Elion-Hitchings Building
General information
Architectural style Brutalist
Location3030 East Cornwallis Road, Research Triangle Park, North Carolina, U.S.
Coordinates 35°54′43″N78°52′09″W / 35.911971°N 78.869282°W / 35.911971; -78.869282
Construction started1969
Completed1972
Design and construction
Architect(s) Paul Rudolph

The Elion-Hitchings Building on Cornwallis Road in Research Triangle Park, North Carolina, U.S. was an architecturally significant brutalist building designed by Paul Rudolph and completed in 1972 as the headquarters for Burroughs Wellcome. Part of the original building and a later addition were torn down, and despite opposition, the rest of the building was demolished in January 2021.

Contents

Background

Burroughs Wellcome & Company, founded in 1880 in London, [1] established research and manufacturing facilities in the 1920s in Tuckahoe, New York, [2] [3] which served as the US headquarters until the company moved to Research Triangle Park in North Carolina in 1972. [4] [5] Being able to attract Burroughs Wellcome helped establish the significance of RTP as a national center for business. [6] :2

When Burroughs Wellcome decided to move its headquarters in 1969, the company selected Paul Rudolph to design its new building, which would serve as both a headquarters and a research facility. [5]

The original building

The 300,000-square-foot building [5] "was celebrated worldwide when it was built," according to Paul Rudolph Heritage Foundation president Kelvin Dickinson. [7] Rudolph was known for brutalism, and a Historic American Buildings Survey dated 2018 said the building was "frequently described as Brutalist" and that its design was inspired by Frank Lloyd Wright's Fallingwater and Rudolph's work on Lower Manhattan Expressway. [6] :3 Rudolph's design was "an A-frame with terraced floors and angled walls and windows" [7] with "an eccentrically loaded trapezoidal steel frame with columns inclined at 22.5 degrees." [8] The design used concrete panels to create "an elongated hexagonal module that gives the building a strong horizontal reading on the long elevations". [5] Also, the design uses "hexagonal geometry on the short elevations, pulling out of the building in different ways to express its ability to expand. In plan, the building wraps around two courts that face in opposite directions in a sort of S configuration." [5] These courts act as a front porch entrance and a service court for the offices and laboratories. The entrance had three levels [5] with columns suggesting Antebellum architecture [6] :7 and goes against the "form follows function" idea of Louis Sullivan, instead suggesting futuristic ideas but requiring a person to go inside to understand the building's purpose. [6] :14 The laboratories have high ceilings with skylights providing some of the lighting. [5]

The futuristic appearance led to its use in the movie Brainstorm . [5]

Rudolph himself said the building was "architecturally an extension of its site", meaning the wooded hills, and that the use of an A frame made it possible to put as much space as possible on lower floors, while the mechanical systems that needed less space could be at the top. He also said the building was designed to be expanded. [9]

Some people did not like the "aggressively modular" design, and Alex Sayf Cummings of Georgia State University called it a "horrible postmodern Mayan temple". After touring the building in 2016, Cummings wrote that the "iconic building helped define the image of RTP." [7] Myrick Howard of Preservation North Carolina said the building established that RTP was important. [7] In 1996, Chuck Twardy of the News & Observer wrote, "The innovative building set the design standard for RTP and remains the park's most remarkable structure." [7] The building was considered "a local landmark and symbol" not just for the company but for the park. [10] While some of the more uptight employees wanted "innovation" but were dismayed when they saw how it appeared, the building became a symbol of what RTP meant and was even used in the park's promotional materials. [6] :14

Later developments

A 130,000-square-foot wing [6] :9 with more offices and a dining room was described as utilizing characteristics of the original building, turning the original building into an L shape. Rudolph wanted the L eventually turned into a U-shape. The A-frame became a V which was repeated, [5] but the angle for the structural steel in the original building was not used. This wing has since been torn down. [6] :9

In 1988 the building was named for [7] the Nobel Prize winning scientists Gertrude B. Elion and George H. Hitchings, who worked at Burroughs Wellcome and invented drugs still used many years later. [11]

Glaxo P.L.C. acquired Wellcome P.L.C. in 1995 and GlaxoWellcome merged with SmithKline Beecham in 2000 to form GlaxoSmithKline. [12] [13]

GlaxoSmithKline moved all of its operations from Cornwallis Road and Maughn Road to Moore Drive in 2011. United Therapeutics, which opened a research and manufacturing facility in 2009 next door, bought the building from GlaxoSmithKline along with 140 acres and two other buildings, for $17.5 million in a deal that closed in June 2012. [14] The new owner tore down 400,000 square feet of the buildings in 2014, while promising to make an effort to save the remaining 150,000 square feet. [6] :7 According to Dickinson, United Therapeutics actually did nothing other than offer tours, while the building continued to deteriorate. [8] As of 2018, the status was "renovation and extension planned". [6] :2

Demolition

United Therapeutics received a permit on September 4, 2020, to tear down the remainder of the building, [8] claiming it was too deteriorated and too expensive to renovate. [7] Design critic Alexandra Lange and modern architecture conservation nonprofit Docomomo US announced the news September 10 on social media, and Dickinson said making people around the world aware was the key to saving the building. [8] Late in September 2020, a petition opposing this action had 2500 signatures. [7] [8]

On January 18, 2021, images appeared on Twitter showing the last standing portions of the building being torn down. [15]

Related Research Articles

<span class="mw-page-title-main">Tuckahoe (village), New York</span> Village in New York, United States

Tuckahoe is a village in Westchester County, New York, United States. One-and-a-half miles long and three-fourths of a mile wide, with the Bronx River serving as its western boundary, the Village of Tuckahoe is approximately sixteen miles north of midtown Manhattan in Southern Westchester County. As of the 2010 census, the village's population was 6,486.

<span class="mw-page-title-main">GSK plc</span> British multinational pharmaceutical and biotechnology company

GSK plc is a British multinational pharmaceutical and biotechnology company with global headquarters in London. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham, GSK is the tenth largest pharmaceutical company and #294 on the 2022 Fortune Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck Sharp & Dohme.

<span class="mw-page-title-main">Gertrude B. Elion</span> American biochemist and pharmacologist (1918–1999)

Gertrude "Trudy"Belle Elion was an American biochemist and pharmacologist, who shared the 1988 Nobel Prize in Physiology or Medicine with George H. Hitchings and Sir James Black for their use of innovative methods of rational drug design for the development of new drugs. This new method focused on understanding the target of the drug rather than simply using trial-and-error. Her work led to the creation of the anti-retroviral drug AZT, which was the first drug widely used against AIDS. Her well known works also include the development of the first immunosuppressive drug, azathioprine, used to fight rejection in organ transplants, and the first successful antiviral drug, acyclovir (ACV), used in the treatment of herpes infection.

<span class="mw-page-title-main">Research Triangle Park</span> Research park in North Carolina, United States

The year 1972 in architecture involved some significant architectural events and new buildings.

<span class="mw-page-title-main">Wellcome Trust</span> British healthcare research charity established in 1936

The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome to fund research to improve human and animal health. The aim of the Trust is to "support science to solve the urgent health challenges facing everyone." It had a financial endowment of £29.1 billion in 2020, making it the fourth wealthiest charitable foundation in the world. In 2012, the Wellcome Trust was described by the Financial Times as the United Kingdom's largest provider of non-governmental funding for scientific research, and one of the largest providers in the world. According to their annual report, the Wellcome Trust spent GBP £1.1Bn on charitable activities across their 2019/2020 financial year. According to the OECD, the Wellcome Trust's financing for 2019 development increased by 22% to US$327 million.

<span class="mw-page-title-main">George H. Hitchings</span> Nobel Prize-winning American doctor (1905–1998)

George Herbert Hitchings was an American medical doctor who shared the 1988 Nobel Prize in Physiology or Medicine with Sir James Black and Gertrude Elion "for their discoveries of important principles for drug treatment", Hitchings specifically for his work on chemotherapy.

KlingStubbins was an architectural, engineering, interior, and planning firm headquartered in Philadelphia, with offices in Cambridge, Massachusetts; Raleigh, North Carolina; San Francisco; Washington, D.C.; and Beijing. In 1982, the Franklin Institute awarded Vincent G. Kling the Frank P. Brown Medal.

<span class="mw-page-title-main">Paul Rudolph (architect)</span> American architect (1918–1997)

Paul Marvin Rudolph was an American architect and the chair of Yale University's Department of Architecture for six years, known for his use of reinforced concrete and highly complex floor plans. His most famous work is the Yale Art and Architecture Building, a spatially-complex Brutalist concrete structure. He is one of the modernist architects considered an early practitioner of the Sarasota School of Architecture.

<span class="mw-page-title-main">Cisatracurium besilate</span> Chemical compound

Cisatracurium besilate is a bisbenzyltetrahydroisoquinolinium that has effect as a neuromuscular-blocking drug non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It shows intermediate duration of action. Cisatracurium is one of the ten isomers of the parent molecule, atracurium. Moreover, cisatracurium represents approximately 15% of the atracurium mixture.

<span class="mw-page-title-main">Andrew Witty</span> British business executive (born 1964)

Sir Andrew Philip Witty is a British business executive, who is the current chief executive officer (CEO) of UnitedHealth Group. He was also the CEO of GlaxoSmithKline between 2008 and 2017. He formerly held the role of chancellor of the University of Nottingham.

The Burroughs Wellcome Fund (BWF) is an American non-profit medical research organization that provides funding for biomedical research, STEM education, and areas of career development for scientists. Since 1970, it has been headquartered in North Carolina's Research Triangle Park.

Campbell Alliance was a specialized management consulting firm that served the pharmaceutical and biotechnology industry. The firm was founded in 1997 by John Campbell, a former executive of GlaxoWellcome, now GlaxoSmithKline, and is a consulting business segment of inVentiv Health, Inc.

<span class="mw-page-title-main">Gantacurium chloride</span> Chemical compound

Gantacurium chloride is a new experimental neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Gantacurium is not yet available for widespread clinical use: it is currently undergoing Phase III clinical development.

<span class="mw-page-title-main">Stiefel Laboratories</span> American corporation

Stiefel Laboratories is an American dermatological pharmaceutical company, with its global headquarters in Research Triangle Park, North Carolina. It makes products such as Duac and Oilatum. Stiefel was acquired by GlaxoSmithKline at a price of $2.9 billion. The company was founded in 1847 by John David Stiefel, Ferdinand von Hebra and Paul Unna, who initially created medicated soaps.

The pharmaceutical industry in the United Kingdom directly employs around 73,000 people and in 2007 contributed £8.4 billion to the UK's GDP and invested a total of £3.9 billion in research and development. In 2007 exports of pharmaceutical products from the UK totalled £14.6 billion, creating a trade surplus in pharmaceutical products of £4.3 billion.

J. W. Chorley Elementary School was a modernist architecture school building in Middletown, New York designed by American architect Paul Rudolph while he was serving as Dean of the Yale School of Architecture. The school was torn down in November 2012.

Janet Rideout is an organic chemist and one of the scientists who discovered that azidothymidine (AZT) could be used as an antiretroviral agent to treat Human Immunodeficiency Virus (HIV). She also played a key role in the development of acyclovir, the first effective treatment for herpes simplex virus.

<span class="mw-page-title-main">New Frontiers Science Park</span> Science park, former research centre in Harlow, Essex

The New Frontiers Science Park is a science park in Essex, on a redeveloped research site of GlaxoSmithKline (GSK).

References

  1. "Burroughs, Wellcome and Co". Grace's Guide to Industrial History. Retrieved November 12, 2020.
  2. "Addition to Factory", The Eastchester Citizen-Bulletin, 19 November 1924
  3. Peter Pennoyer, Anne Walker, The Architecture of Delano & Aldrich, W. W. Norton & Company, 2003, p.  188.
  4. "Burroughs Wellcome Building - Elion-Hitchings Building" . Retrieved November 12, 2020.
  5. 1 2 3 4 5 6 7 8 9 De Alba, Roberto (2003). Paul Rudolph: The Late Work. Princeton Architectural Press. p. 168.
  6. 1 2 3 4 5 6 7 8 9 "Historic American Buildings Survey: Burroughs Wellcome Headquarters (Elion-Hitchings Building)" (PDF). National Park Service. 2018. Retrieved November 14, 2020.
  7. 1 2 3 4 5 6 7 8 Stradling, Richard (September 21, 2020). "United Therapeutics to demolish an RTP landmark building". News & Observer .
  8. 1 2 3 4 5 Hickman, Matt (September 11, 2020). "Paul Rudolph's Burroughs Wellcome headquarters building in North Carolina threatened with demolition". The Architect's Newspaper. Retrieved November 14, 2020.
  9. Moholy-Nagy, Sibyl (1970). The Architecture of Paul Rudolph. Praeger. p. 233.
  10. History of the Burroughs-Wellcome Fund: 1955-2005 (PDF). Historic Preservation Fund of North Carolina, Inc. 2005. p. 25.
  11. Bouton, Katherine (January 29, 1989). "The Nobel Pair". The New York Times . Retrieved March 12, 2020.
  12. Stevenson, Richard W. (January 24, 1995). "Company News; Glaxo Offers $14 Billion for Wellcome". The New York Times . Retrieved November 14, 2020.
  13. Birkett, Kirsten (May 1, 2001). "Inside the Glaxo Wellcome and SmithKline merger". Thomson Reuters Practical Law . Retrieved November 14, 2020.
  14. Hoyle, Amanda (June 29, 2012). "UT deepens stake here with RTP purchase". Triangle Business Journal . Retrieved November 13, 2020.
  15. John Hill [@archidose] (Jan 18, 2021). "Gut-wrenching photos of Paul Rudolph's 1972 Burroughs-Wellcome building coming down" (Tweet) via Twitter.