Elizabeth Rhoades

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Anna Elizabeth Rhoades is a molecular biophysicist at University of Pennsylvania. [1] She is known for pioneering studies of protein folding using single-molecule techniques.

Contents

Education

Rhoades received her undergraduate education at Duke University, followed by Ph.D. studies at the University of Michigan, Ann Arbor in biophysics. Her dissertation supervisor was Ari Gafni. [2]

She performed postdoctoral research in the laboratory of Gilad Haran [3] at the Weizmann Institute in Rehovot, Israel. While at the Weizmann Institute, Rhoades was involved in revolutionary single-molecule experiments studying the folding and unfolding of immobilized proteins. [4] [5] Rhoades completed her postdoctoral research with Watt W. Webb at Cornell University, one of the co-inventors of fluorescence correlation spectroscopy.

Research

Rhoades studies intrinsically disordered proteins and amyloidogenic proteins involved in Parkinson's disease, Alzheimer's disease and Type-II diabetes.

Research in the Rhoades lab aims to elucidate the principles that link protein conformational change with structure-function relationships, focusing on understanding structural plasticity in intrinsically disordered proteins. These proteins do not form stable structures under physiological conditions; for many, function is dependent upon disorder. This is in striking contrast to the structure-function paradigm that dominates our understanding of globular proteins. Given the large fraction of the eukaryotic proteome predicted to be disordered, the scope of the problem and the need for new insights are enormous. [6]

Awards

References

  1. ↑ "Anna Elizabeth Rhoades". Yale Phonebook. Yale University.[ permanent dead link ]
  2. ↑ Ari Gafni, University of Michigan
  3. ↑ Gilad Haran, Weizmann Institute
  4. ↑ Rhoades E, Gussakovsky E, Haran G (March 2003). "Watching proteins fold one molecule at a time". Proc. Natl. Acad. Sci. U.S.A. 100 (6): 3197–202. Bibcode:2003PNAS..100.3197R. doi: 10.1073/pnas.2628068100 . PMC   152269 . PMID   12612345.
  5. ↑ Rhoades E, Cohen M, Schuler B, Haran G (November 2004). "Two-state folding observed in individual protein molecules". J. Am. Chem. Soc. 126 (45): 14686–7. CiteSeerX   10.1.1.702.7305 . doi:10.1021/ja046209k. PMID   15535670.
  6. ↑ Rhoades Lab, University of Pennsylvania
  7. ↑ "Elizabeth Rhoades to Receive 2019 BPS Michael and Kate Barany Award" . Retrieved 2020-02-02.
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