Since 2014, Poeschla has been Professor of Medicine and Chief of the Infectious Diseases Division at the University of Colorado School of Medicine, where he also holds the Tim Gill Endowed Chair in HIV Research and has helped direct the institutional response to the COVID-19 pandemic.[3][4][5] Poeschla was elected to the Association of American Physicians (AAP) in 2016. He lives in Denver.
Research
Poeschla's laboratory is interested in how viruses interact with, use, or evade cellular proteins as they replicate, as well as innate immunity, and viral emergence. Early work determined how FIV, the feline HIV-like virus, carries out its life cycle. It also established FIV-based lentiviral vectors.[6][7]
Subsequent research included contributions to identifying the role of a cellular protein (LEDGF) in the chromosomal attachment and integration step of HIV, and investigations of other cellular factors that regulate the HIV life cycle.[8][9][10][11][12] More recent studies have further concerned cellular innate immune defenses to other RNA viruses as well. The laboratory uses picornavirus RNA polymerase-transgenic mouse models to investigate Interferon-stimulated gene (ISG) responses triggered by viral double-stranded RNA via the sensor MDA5.[13][14][15]
In 2020, a restriction to primate lentiviruses (HIV and related simian viruses) was reported in cells of large bats.[16]
↑ Poeschla, E. M.; Wong-Staal, F.; Looney, D. J. (1998). "Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors". Nature Medicine. 4 (3): 354–357. doi:10.1038/nm0398-354. ISSN1078-8956. PMID9500613. S2CID6624732.
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