Ernst angle

Last updated

In nuclear magnetic resonance spectroscopy and magnetic resonance imaging, the Ernst angle is the flip angle (a.k.a. "tip" or "nutation" angle) for excitation of a particular spin that gives the maximal signal intensity in the least amount of time when signal averaging over many transients. In other words, the highest signal-to-noise ratio can be achieved in a given amount of time. This relationship was described by Richard R. Ernst, winner of the 1991 Nobel Prize in Chemistry. [1] [2]

Consider a single pulse sequence consisting of (1) an excitation pulse with flip angle , (2) the recording of the time domain signal (Free induction decay, FID) for a duration known as acquisition time , and (3) a delay until the next excitation pulse (here called interpulse delay ). This sequence is repeated back-to-back many times and the sum or the average of all recorded FIDs ("transients") is calculated. If the longitudinal relaxation time of the specific spin in question is short compared to the sum of and , the spins (or the spin ensembles) are fully or close to fully relaxed. Then a 90° flip angle will yield the maximum signal intensity (or signal-to-noise ratio) per number of averaged FIDs. For shorter intervals between excitation pulses compared to the longitudinal relaxation, partial longitudinal relaxation until the next excitation pulse leads to signal loss in the subsequent FID. This signal loss can be minimized by reducing the flip angle. The optimal signal-to-noise ratio for a given combination of longitudinal relaxation time and delay between excitation pulses is obtained at the Ernst angle:

.

For example, to obtain the highest signal-to-noise ratio for a signal with set to match the signal's , the optimal flip angle is 68°.

An NMR spectrum or an in vivo MR spectrum most of the time consists of signals of more than one spin species which can exhibit different longitudinal relaxation times. Therefore, the calculated Ernst angle may apply only to the selected one of the many signals in the spectrum and other signals may be less intense than at their own Ernst angle. In contrast in standard MRI, the detected signal of interest is predominantly that of a single spin species, the water 1H spins.

This relationship is especially important in magnetic resonance imaging where the sum of interscan delay and acquisition time is often short relative to the signal's value. In the MRI community, this sum is often known as repetition time , thus

,

and, consequently,

Related Research Articles

Spherical coordinate system 3-dimensional coordinate system

In mathematics, a spherical coordinate system is a coordinate system for three-dimensional space where the position of a point is specified by three numbers: the radial distance of that point from a fixed origin, its polar angle measured from a fixed zenith direction, and the azimuthal angle of its orthogonal projection on a reference plane that passes through the origin and is orthogonal to the zenith, measured from a fixed reference direction on that plane. It can be seen as the three-dimensional version of the polar coordinate system.

In geometry, a solid angle is a measure of the amount of the field of view from some particular point that a given object covers. That is, it is a measure of how large the object appears to an observer looking from that point. The point from which the object is viewed is called the apex of the solid angle, and the object is said to subtend its solid angle at that point.

The nuclear Overhauser effect (NOE) is the transfer of nuclear spin polarization from one population of spin-active nuclei to another via cross-relaxation. A phenomenological definition of the NOE in nuclear magnetic resonance spectroscopy (NMR) is the change in the integrated intensity of one NMR resonance that occurs when another is saturated by irradiation with an RF field. The change in resonance intensity of a nucleus is a consequence of the nucleus being close in space to those directly affected by the RF perturbation.

<span class="mw-page-title-main">Inverse trigonometric functions</span> Arcsin, arccos, arctan, etc

In mathematics, the inverse trigonometric functions are the inverse functions of the trigonometric functions. Specifically, they are the inverses of the sine, cosine, tangent, cotangent, secant, and cosecant functions, and are used to obtain an angle from any of the angle's trigonometric ratios. Inverse trigonometric functions are widely used in engineering, navigation, physics, and geometry.

Solid-state nuclear magnetic resonance

Solid-state NMR (ssNMR) spectroscopy is a technique for characterizing atomic level structure in solid materials e.g. powders, single crystals and amorphous samples and tissues using nuclear magnetic resonance (NMR) spectroscopy. The anisotropic part of many spin interactions are present in solid-state NMR, unlike in solution-state NMR where rapid tumbling motion averages out many of the spin interactions. As a result, solid-state NMR spectra are characterised by larger linewidths than in solution state NMR, which can be utilized to give quantitative information on the molecular structure, conformation and dynamics of the material. Solid-state NMR is often combined with magic angle spinning to remove anisotropic interactions and improve the resolution as well as the sensitivity of the technique.

The magic angle is a precisely defined angle, the value of which is approximately 54.7356°. The magic angle is a root of a second-order Legendre polynomial, P2(cos θ) = 0, and so any interaction which depends on this second-order Legendre polynomial vanishes at the magic angle. This property makes the magic angle of particular importance in magic angle spinning solid-state NMR spectroscopy. In magnetic resonance imaging, structures with ordered collagen, such as tendons and ligaments, oriented at the magic angle may appear hyperintense in some sequences; this is called the magic angle artifact or effect.

Muon spin spectroscopy

Muon spin spectroscopy, also known as µSR, is an experimental technique based on the implantation of spin-polarized muons in matter and on the detection of the influence of the atomic, molecular or crystalline surroundings on their spin motion. The motion of the muon spin is due to the magnetic field experienced by the particle and may provide information on its local environment in a very similar way to other magnetic resonance techniques, such as electron spin resonance and, more closely, nuclear magnetic resonance (NMR).

In MRI and NMR spectroscopy, an observable nuclear spin polarization (magnetization) is created by a homogeneous magnetic field. This field makes the magnetic dipole moments of the sample precess at the resonance (Larmor) frequency of the nuclei. At thermal equilibrium, nuclear spins precess randomly about the direction of the applied field. They become abruptly phase coherent when they are hit by radiofrequent (RF) pulses at the resonant frequency, created orthogonal to the field. The RF pulses cause the population of spin-states to be perturbed from their thermal equilibrium value. The generated transverse magnetization can then induce a signal in an RF coil that can be detected and amplified by an RF receiver. The return of the longitudinal component of the magnetization to its equilibrium value is termed spin-latticerelaxation while the loss of phase-coherence of the spins is termed spin-spin relaxation, which is manifest as an observed free induction decay (FID).

There are several equivalent ways for defining trigonometric functions, and the proof of the trigonometric identities between them depend on the chosen definition. The oldest and somehow the most elementary definition is based on the geometry of right triangles. The proofs given in this article use this definition, and thus apply to non-negative angles not greater than a right angle. For greater and negative angles, see Trigonometric functions.

During nuclear magnetic resonance observations, spin–lattice relaxation is the mechanism by which the longitudinal component of the total nuclear magnetic moment vector (parallel to the constant magnetic field) exponentially relaxes from a higher energy, non-equilibrium state to thermodynamic equilibrium with its surroundings (the "lattice"). It is characterized by the spin–lattice relaxation time, a time constant known as T1.

<i>k</i>-space (magnetic resonance imaging)

In magnetic resonance imaging (MRI), k-space is the 2D or 3D Fourier transform of the image measured. It was introduced in 1979 by Likes and in 1983 by Ljunggren and Twieg.

<span class="mw-page-title-main">Clutter (radar)</span>

Clutter is a term used for unwanted echoes in electronic systems, particularly in reference to radars. Such echoes are typically returned from ground, sea, rain, animals/insects, chaff and atmospheric turbulences, and can cause serious performance issues with radar systems.

Nuclear magnetic resonance (NMR) in porous materials covers the application of using NMR as a tool to study the structure of porous media and various processes occurring in them. This technique allows the determination of characteristics such as the porosity and pore size distribution, the permeability, the water saturation, the wettability, etc.

<span class="mw-page-title-main">Nuclear magnetic resonance</span> Spectroscopic technique based on change of nuclear spin state

Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca. 20 tesla, the frequency is similar to VHF and UHF television broadcasts (60–1000 MHz). NMR results from specific magnetic properties of certain atomic nuclei. Nuclear magnetic resonance spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics and crystals as well as non-crystalline materials. NMR is also routinely used in advanced medical imaging techniques, such as in magnetic resonance imaging (MRI).

<span class="mw-page-title-main">Physics of magnetic resonance imaging</span> Overview article

The physics of magnetic resonance imaging (MRI) concerns fundamental physical considerations of MRI techniques and technological aspects of MRI devices. MRI is a medical imaging technique mostly used in radiology and nuclear medicine in order to investigate the anatomy and physiology of the body, and to detect pathologies including tumors, inflammation, neurological conditions such as stroke, disorders of muscles and joints, and abnormalities in the heart and blood vessels among others. Contrast agents may be injected intravenously or into a joint to enhance the image and facilitate diagnosis. Unlike CT and X-ray, MRI uses no ionizing radiation and is, therefore, a safe procedure suitable for diagnosis in children and repeated runs. Patients with specific non-ferromagnetic metal implants, cochlear implants, and cardiac pacemakers nowadays may also have an MRI in spite of effects of the strong magnetic fields. This does not apply on older devices, details for medical professionals are provided by the device's manufacturer.

Pulsed electron paramagnetic resonance

Pulsed electron paramagnetic resonance (EPR) is an electron paramagnetic resonance technique that involves the alignment of the net magnetization vector of the electron spins in a constant magnetic field. This alignment is perturbed by applying a short oscillating field, usually a microwave pulse. One can then measure the emitted microwave signal which is created by the sample magnetization. Fourier transformation of the microwave signal yields an EPR spectrum in the frequency domain. With a vast variety of pulse sequences it is possible to gain extensive knowledge on structural and dynamical properties of paramagnetic compounds. Pulsed EPR techniques such as electron spin echo envelope modulation (ESEEM) or pulsed electron nuclear double resonance (ENDOR) can reveal the interactions of the electron spin with its surrounding nuclear spins.

Hyperpolarized carbon-13 MRI is a functional medical imaging technique for probing perfusion and metabolism using injected substrates.

Adiabatic radio frequency (RF) pulses are used in magnetic resonance imaging (MRI) to achieve excitation that is insensitive to spatial inhomogeneities in the excitation field or off-resonances in the sampled object.

An MRI artifact is a visual artifact in magnetic resonance imaging (MRI). It is a feature appearing in an image that is not present in the original object. Many different artifacts can occur during MRI, some affecting the diagnostic quality, while others may be confused with pathology. Artifacts can be classified as patient-related, signal processing-dependent and hardware (machine)-related.

References

  1. "1991 Nobel Laureates in Chemistry".
  2. Ernst, R. R. (1966). "Application of Fourier transform spectroscopy to magnetic resonance". Review of Scientific Instruments. 37 (1): 93–102. Bibcode:1966RScI...37...93E. doi:10.1063/1.1719961.