Exposome

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Example representation of the environmental factors characterizing the exposome. Exposome nruaux.jpg
Example representation of the environmental factors characterizing the exposome.

The exposome is a concept used to describe environmental exposures that an individual encounters throughout life, and how these exposures impact biology and health. It encompasses both external and internal factors, including chemical, physical, biological, and social factors that may influence human health. [1] [2] [3]

Contents

The study of the exposome has become a useful tool in understanding the interplay between genetics and environmental factors in the development of diseases, with a particular focus on chronic conditions. [4] The concept has been widely applied in fields such as epidemiology, toxicology, and public health, among others, and has led to significant advances [5] in our understanding of disease etiology and prevention.

By considering the cumulative effect of multiple exposures, it provides a holistic approach to the study of gene-environment interactions, allowing for a more accurate assessment [6] of disease risk and the identification of potential intervention strategies. [7]

Environmental exposures can have a significant impact on an individual's health. Exposure to air pollution, for example, has been linked to an increased risk of respiratory disease, heart disease, and even premature death. Similarly, exposure to certain chemicals in consumer products has been linked to an increased risk of cancer and other health problems. [5] In addition to external factors, the internal exposome can also influence an individual's health outcomes. For example, genetics can play a role in how an individual's body processes and responds to environmental exposures, [7] while the gut microbiome can affect an individual's immune system and overall health. As our understanding of the exposome continues to evolve, it is likely that we will gain new insights into the complex interplay between our environment and our health.

History

The term "exposome" was first coined in 2005 by Dr. Christopher Wild, [1] then-director of the International Agency for Research on Cancer (IARC), in a seminal paper published in Cancer Epidemiology, Biomarkers & Prevention. Wild's concept was initially proposed to complement the human genome, as he recognized the limitations of genetic research in explaining the etiology of chronic diseases. By suggesting a systematic approach to measuring environmental exposures, the exposome aimed to fill this knowledge gap. [8]

Various definitions of the exposome have been proposed over time, but most emphasize three main components: the external exposome, the internal exposome, and the biological response. [6] The external exposome includes general external factors, such as air pollution, diet, and socioeconomic factors, as well as specific external factors like chemicals and radiation. The internal exposome comprises endogenous factors, such as hormones, inflammation, oxidative stress, and gut microbiota. Finally, the biological response refers to the complex interactions between the external and internal exposome factors and their influence on an individual's physiology and health [9]

Significance

The field of exposome research is relatively new, rapidly evolving, and is still being developed and refined [10] by researchers in a variety of fields, including epidemiology, environmental health, and genomics. Understanding the exposome is important because it can help researchers identify the environmental factors that contribute to disease, and develop strategies for prevention and treatment.[ citation needed ]

The exposome concept presents several challenges for researchers. One of the main challenges is the complexity and diversity of exposures that individuals experience throughout their lifetime. [11] There are thousands of chemicals in the environment, [12] and individuals are exposed to different combinations of chemicals depending on their location, occupation, and lifestyles. [6] Besides this, a lack of standardized methods for measuring exposures is also challenging. [13] Traditional approaches to measuring environmental exposures have relied on individual exposure assessments, which are often expensive and time-consuming. [14] New technologies, such as high-throughput methods for measuring multiple exposures simultaneously, [15] are being developed [16] to address this challenge.

Understanding exposomes has significant implications for public health [17] and the development of more effective strategies for prevention and treatment of disease. [18] For example, if research shows that exposure to a certain chemical is linked to an increased risk of cancer, [19] policymakers can take steps to regulate or ban the use of that chemical. [20]

In addition to informing public health policies, the study of the exposome can also help individuals make more informed choices about their own health. [5] By understanding the environmental factors that contribute to disease, individuals can take steps to reduce their exposure to harmful substances and improve their overall health. [6] [21] [22] [12]

The exposome concept holds great promise [23] for advancing our understanding of the complex interplay between environmental exposures and human health. [24] As researchers continue to refine exposure assessment methods, identify novel biomarkers, and develop sophisticated computational approaches, the exposome framework is poised to revolutionize the fields of epidemiology, toxicology, and public health. [25] [26]

Global initiatives

There have been several research initiatives aimed to better understand the exposome. One such initiative was the "Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe", [27] a program by the Imperial College of Science, Technology and Medicine in the UK. A current initiative is EXIMIOUS [28] - a 5 year Research and Innovation Action funded by the European Union's Horizon 2020 program, aimed at introducing a new approach to mapping exposure-induced immune effects by combining exposomics and immunomics in a unique toolbox. Another is the National Institutes of Health's Environmental Influences on Child Health Outcomes (ECHO) program, [29] which is studying the impact of these factors on children's health. We also have the Human Exposome Project, [30] a collaborative effort between researchers from around the world to develop tools and techniques to measure and analyze the exposome.

Furthermore, several European countries, including Sweden, France, Austria, and Czechia, have been actively involved in establishing dedicated research infrastructures for exposomics. In Sweden, the National Facility for Exposomics [31] was approved in November 2020 and is hosted by the University of Stockholm. The facility is currently operational in Solna, providing resources and expertise for exposomics research. France has also established a dedicated research infrastructure, France Exposome, [32] a new National Research Infrastructure that focuses on environmental health. It has been included in the 2021 roadmap for the research infrastructure of the Ministry of Higher Education and Research, indicating its significance in the country's research landscape.[ citation needed ]

Additionally, the Environmental Exposure Assessment Research Infrastructure (EIRENE) [33] is a collaborative effort consisting of 17 National Nodes representing around 50 institutions with complementary expertise. EIRENE aims to fill the gap in the European infrastructural landscape and pioneer the first EU infrastructure on the human exposome. The consortium has a geographically balanced network, covering Northern (Finland, Iceland, Norway, Sweden), Western (Belgium, France, Germany, Netherlands, UK), Southern (Greece, Italy, Slovenia, Spain), and Central and Eastern (Austria, Czech Republic, Slovakia) Europe, as well as the US. The EIRENE RI team consists of scientists leading exposome research on an international level.

These initiatives reflect the growing recognition of the importance of exposomics research and the commitment of these countries to advancing the field. The establishment of dedicated research infrastructures ensures the availability of resources and expertise required to uncover crucial insights into the impact of exposomes [10] on human health.

Methodologies

The study of the exposome requires a multi-disciplinary approach that combines advances in exposure assessment, bioinformatics, and systems biology. As such, researchers have developed a range of key methodologies to measure and analyze the exposome – from exposure assessment techniques, analytical tools, to computational approaches.[ citation needed ]

These methods are designed to capture and analyze the diverse and dynamic nature of environmental exposures across a person's lifespan.[ citation needed ]

Exposure assessment

The assessment of environmental exposures is a critical aspect of exposome research. Traditional methods, such as questionnaires and environmental monitoring, provide useful information on external factors but may not adequately capture the complexity and variability of exposures over time. [7]

Consequently, researchers have increasingly turned to personal monitoring devices, such as wearable sensors, personal monitoring devices, and smartphone applications, which can collect real-time data on an individual's exposure to various environmental factors, such as air pollution, noise, and ultraviolet radiation. [21] [34] The data collected by these devices can help researchers understand how personal behaviors and microenvironments contribute to overall exposome profiles. [35] [36] [37]

Biomarkers

Biomarkers (measurable indicators of biological processes or conditions) play an essential role in characterizing the internal exposome and biological response. This approach involves the measurement of chemicals or their metabolites in biological specimens such as blood, urine, or tissues. [22] [38] [39] Advances in high-throughput -omics technologies such as genomics, transcriptomics, proteomics, and metabolomics, have revolutionized our ability to measure thousands of biomarkers simultaneously. This can provide a detailed snapshot of an individual's molecular profile at a given time, as well as a comprehensive view of the individual's biological response to environmental exposures. [14] These technologies yield a direct and quantitative assessment of an individual's exposure to specific compounds and have been increasingly incorporated into exposome research and epidemiological studies. [39]

Geographic Information Systems (GIS)

GIS tools can be used to estimate an individual's exposure to environmental factors based on spatial data, such as air pollution or proximity to hazardous waste sites. [40] GIS-based exposure assessment has been applied in numerous epidemiological studies to investigate the relationship between environmental exposures and health outcomes. [41] [42]

Computational approaches

The vast amounts of data generated by exposome research require advanced computational methods for storage, analysis, and interpretation. Machine learning [43] and other data mining techniques [44] have emerged as valuable tools for identifying patterns and relationships within complex exposome data sets. Furthermore, systems biology approaches, which integrate data from multiple -omics platforms [45] can help elucidate the complex interactions between exposures and biological pathways that contribute to disease development. [46]

Applications

Epidemiology

Exposome research has had a significant impact on the field of epidemiology, providing new insights into the complex relationships between environmental exposures, genetic factors, and human health. [47] By comprehensively assessing the totality of exposures, epidemiologists can better understand the etiology of chronic diseases, such as cancer, cardiovascular disease, and neurodegenerative disorders, and identify modifiable risk factors that may be targets for intervention. [48]

Large-scale exposome projects, such as the Human Early-Life Exposome (HELIX) project [7] and the European Exposome Cluster, have been established to investigate these relationships and generate new knowledge on disease etiology and prevention. [49]

Toxicology

The exposome has also influenced the field of toxicology, leading to the development of new methods for assessing the cumulative effects of multiple environmental exposures on human health. By integrating exposure data with molecular profiling techniques, [50] toxicologists can better understand the mechanisms through which environmental chemicals and other factors contribute to adverse health outcomes. This knowledge can inform the development of more effective strategies for chemical risk assessment and regulation. [11]

Public Health

Public health research and practice have greatly benefited from the insights gained through exposome research. By elucidating the complex interactions between environmental exposures and human health, the exposome framework can inform the design of targeted interventions to reduce disease risk and promote health equity. [18]

Moreover, the development of exposome-based tools, such as biomonitoring and personal exposure monitoring devices, can help public health practitioners better track population exposures [51] and evaluate the effectiveness of interventions.

Challenges and future directions

Despite significant advances in exposome research, several challenges remain, including the development of more accurate exposure assessment techniques, the identification of novel biomarkers, and the management of large- scale and complex data sets. [3]

Exposure assessment

One of the main challenges in exposome research is the accurate assessment of exposures across an individual's lifetime. [26] While recent technological advancements have improved our ability to measure environmental exposures in real-time, there is still a need for methods that can retrospectively assess historical exposures, [2] particularly in the context of chronic disease research. [52]

Biomarker identification

Another challenge lies in the identification of novel and informative biomarkers that can provide insights into the biological pathways underlying exposure-disease relationships. [14] While omics technologies have greatly expanded the number of measurable biomarkers, researchers must still determine [53] which of these markers are most relevant to specific health outcomes and how they may be affected by various exposures.

Data management

Exposome research generates vast amounts of complex data, [54] posing challenges related to data storage, analysis, and interpretation. As the field continues to grow, the development of standardized data formats, data sharing platforms, and advanced computational methods for data integration will be crucial [46] to maximizing the potential of exposome research.

See also

Related Research Articles

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<span class="mw-page-title-main">Environmental health</span> Public health branch focused on environmental impacts on human health

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<span class="mw-page-title-main">Endocrine disruptor</span> Chemicals that can interfere with endocrine or hormonal systems

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<span class="mw-page-title-main">Gene–environment interaction</span> Response to the same environmental variation differently by different genotypes

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References

  1. 1 2 Wild CP (August 2005). "Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology". Cancer Epidemiology, Biomarkers & Prevention. 14 (8): 1847–1850. doi: 10.1158/1055-9965.epi-05-0456 . PMID   16103423. S2CID   6446979.
  2. 1 2 Ottinger MA, Geiselman C (2022). ONE HEALTH AND THE EXPOSOME: Human, wildlife, and ecosystem health. [S.l.]: Elsevier Academic Press. ISBN   978-0-323-89873-7. OCLC   1276932534.
  3. 1 2 Miller GW (2020). The exposome: a new paradigm for the environment and health (Second ed.). London, United Kingdom. ISBN   978-0-12-814080-2. OCLC   1156991933.{{cite book}}: CS1 maint: location missing publisher (link)
  4. ↑ Rappaport SM, Barupal DK, Wishart D, Vineis P, Scalbert A (August 2014). "The blood exposome and its role in discovering causes of disease". Environmental Health Perspectives. 122 (8): 769–774. doi:10.1289/ehp.1308015. PMC   4123034 . PMID   24659601.
  5. 1 2 3 Rappaport SM, Smith MT (October 2010). "Epidemiology. Environment and disease risks". Science. 330 (6003): 460–461. doi:10.1126/science.1192603. PMC   4841276 . PMID   20966241.
  6. 1 2 3 4 Miller GW, Jones DP (January 2014). "The nature of nurture: refining the definition of the exposome". Toxicological Sciences. 137 (1): 1–2. doi:10.1093/toxsci/kft251. PMC   3871934 . PMID   24213143.
  7. 1 2 3 4 Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, et al. (June 2014). "The human early-life exposome (HELIX): project rationale and design". Environmental Health Perspectives. 122 (6): 535–544. doi:10.1289/ehp.1307204. PMC   4048258 . PMID   24610234.
  8. ↑ Wild CP (February 2012). "The exposome: from concept to utility". International Journal of Epidemiology. 41 (1): 24–32. doi: 10.1093/ije/dyr236 . PMID   22296988.
  9. ↑ Rappaport SM, Barupal DK, Wishart D, Vineis P, Scalbert A (August 2014). "The blood exposome and its role in discovering causes of disease". Environmental Health Perspectives. 122 (8): 769–774. doi:10.1289/ehp.1308015. PMC   4123034 . PMID   24659601.
  10. 1 2 Miller GW (2014). The exposome: a primer: the environmental equivalent of the genome. Oxford: Elsevier. ISBN   978-0-12-417218-0. OCLC   877107600.
  11. 1 2 Rappaport SM (January 2011). "Implications of the exposome for exposure science". Journal of Exposure Science & Environmental Epidemiology. 21 (1): 5–9. doi: 10.1038/jes.2010.50 . PMID   21081972. S2CID   858966.
  12. 1 2 Wild CP, Scalbert A, Herceg Z (August 2013). "Measuring the exposome: a powerful basis for evaluating environmental exposures and cancer risk". Environmental and Molecular Mutagenesis. 54 (7): 480–499. Bibcode:2013EnvMM..54..480W. doi:10.1002/em.21777. PMID   23681765. S2CID   29455250.
  13. ↑ Vrijheid M (September 2014). "The exposome: a new paradigm to study the impact of environment on health". Thorax. 69 (9): 876–878. doi: 10.1136/thoraxjnl-2013-204949 . PMID   24906490. S2CID   6843076.
  14. 1 2 3 Dennis KK, Marder E, Balshaw DM, Cui Y, Lynes MA, Patti GJ, et al. (April 2017). "Biomonitoring in the Era of the Exposome". Environmental Health Perspectives. 125 (4): 502–510. doi:10.1289/EHP474. PMC   5381997 . PMID   27385067.
  15. ↑ Jia S, Xu T, Huan T, Chong M, Liu M, Fang W, Fang M (May 2019). "Chemical Isotope Labeling Exposome (CIL-EXPOSOME): One High-Throughput Platform for Human Urinary Global Exposome Characterization". Environmental Science & Technology. 53 (9): 5445–5453. Bibcode:2019EnST...53.5445J. doi:10.1021/acs.est.9b00285. hdl: 10220/48841 . PMID   30943026. S2CID   92998059.
  16. ↑ Nguyen VK, Middleton LY, Huang L, Zhao N, Verly E, Kvasnicka J, Sagers L, Patel CJ, Colacino J, Jolliet O (February 2023). "Harmonized US National Health and Nutrition Examination Survey 1988-2018 for high throughput exposome-health discovery". medRxiv   10.1101/2023.02.06.23284573 .
  17. ↑ Vermeulen R, Schymanski EL, Barabási AL, Miller GW (January 2020). "The exposome and health: Where chemistry meets biology". Science. 367 (6476): 392–396. Bibcode:2020Sci...367..392V. doi:10.1126/science.aay3164. PMC   7227413 . PMID   31974245.
  18. 1 2 Buck Louis GM, Sundaram R (September 2012). "Exposome: time for transformative research". Statistics in Medicine. 31 (22): 2569–2575. doi:10.1002/sim.5496. PMC   3842164 . PMID   22969025.
  19. ↑ Robinson P, Dempsey K (October 2017). "Teaching epidemiology". Australian and New Zealand Journal of Public Health. 41 (5) (4th ed.): 549. doi: 10.1111/1753-6405.12615 . ISSN   1326-0200.
  20. ↑ Siroux V, Agier L, Slama R (June 2016). "The exposome concept: a challenge and a potential driver for environmental health research". European Respiratory Review. 25 (140): 124–129. doi:10.1183/16000617.0034-2016. PMC   9487242 . PMID   27246588.
  21. 1 2 Patel CJ, Ioannidis JP (November 2014). "Placing epidemiological results in the context of multiplicity and typical correlations of exposures". Journal of Epidemiology and Community Health. 68 (11): 1096–1100. doi:10.1136/jech-2014-204195. PMC   4545966 . PMID   24923805.
  22. 1 2 Needham LL, Sexton K (November 2000). "Assessing children's exposure to hazardous environmental chemicals: an overview of selected research challenges and complexities". Journal of Exposure Analysis and Environmental Epidemiology. 10 (6 Pt 2): 611–629. doi:10.1038/sj.jea.7500142. PMID   11138654. S2CID   40739193.
  23. ↑ Dennis KK, Auerbach SS, Balshaw DM, Cui Y, Fallin MD, Smith MT, et al. (October 2016). "The Importance of the Biological Impact of Exposure to the Concept of the Exposome". Environmental Health Perspectives. 124 (10): 1504–1510. doi:10.1289/ehp140. PMC   5047763 . PMID   27258438.
  24. ↑ Vineis P, Chadeau-Hyam M, Gmuender H, Gulliver J, Herceg Z, Kleinjans J, et al. (March 2017). "The exposome in practice: Design of the EXPOsOMICS project". International Journal of Hygiene and Environmental Health. 220 (2 Pt A): 142–151. doi:10.1016/j.ijheh.2016.08.001. PMC   6192011 . PMID   27576363.
  25. ↑ Louis GB, Schisterman EF, Sweeney AM, Gore-Langton R, Lynch CD, Sundaram R (September 2010). "Preconception recruitment of couples desiring pregnancy – case for the exposome". Fertility and Sterility. 94 (4): S229. doi: 10.1016/j.fertnstert.2010.07.890 . ISSN   0015-0282.
  26. 1 2 Robinson O, Vrijheid M (June 2015). "The Pregnancy Exposome". Current Environmental Health Reports. 2 (2): 204–213. doi: 10.1007/s40572-015-0043-2 . PMID   26231368. S2CID   256397149.
  27. ↑ "Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe". CORDIS. EU Publications Office.
  28. ↑ "Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome".
  29. ↑ "Environmental influences on Child Health Outcomes (ECHO) Program". National Institutes of Health (NIH). Retrieved 2023-04-03.
  30. ↑ "Human Exposome Project". EXIMIOUS.
  31. ↑ "Exposomics". SciLifeLab. Retrieved 2023-04-03.
  32. ↑ "Accueil | France Exposome". www.france-exposome.org. Retrieved 2023-04-03.
  33. ↑ "EIRENE Research Infrastructure". Masaryk University. Retrieved 2023-04-03.
  34. ↑ Nieuwenhuijsen MJ, Donaire-Gonzalez D, Rivas I, de Castro M, Cirach M, Hoek G, et al. (March 2015). "Variability in and agreement between modeled and personal continuously measured black carbon levels using novel smartphone and sensor technologies". Environmental Science & Technology. 49 (5): 2977–2982. Bibcode:2015EnST...49.2977N. doi:10.1021/es505362x. PMID   25621420.
  35. ↑ Steinle S, Reis S, Sabel CE (January 2013). "Quantifying human exposure to air pollution--moving from static monitoring to spatio-temporally resolved personal exposure assessment" (PDF). The Science of the Total Environment. 443: 184–193. Bibcode:2013ScTEn.443..184S. doi:10.1016/j.scitotenv.2012.10.098. PMID   23183229.
  36. ↑ Morawska L, Thai PK, Liu X, Asumadu-Sakyi A, Ayoko G, Bartonova A, et al. (July 2018). "Applications of low-cost sensing technologies for air quality monitoring and exposure assessment: How far have they gone?". Environment International. 116: 286–299. Bibcode:2018EnInt.116..286M. doi:10.1016/j.envint.2018.04.018. PMC   6145068 . PMID   29704807.
  37. ↑ Steinle S, Reis S, Sabel CE, Semple S, Twigg MM, Braban CF, et al. (March 2015). "Personal exposure monitoring of PM2.5 in indoor and outdoor microenvironments". The Science of the Total Environment. 508: 383–394. Bibcode:2015ScTEn.508..383S. doi:10.1016/j.scitotenv.2014.12.003. hdl: 1893/27104 . PMID   25497678. S2CID   34590128.
  38. ↑ Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL (February 2005). "Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements". Environmental Health Perspectives. 113 (2): 192–200. doi:10.1289/ehp.7337. PMC   1277864 . PMID   15687057.
  39. 1 2 Rattray NJ, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JP, Johnson CH (January 2018). "Beyond genomics: understanding exposotypes through metabolomics". Human Genomics. 12 (1): 4. doi: 10.1186/s40246-018-0134-x . PMC   5787293 . PMID   29373992.
  40. ↑ Juarez PD, Matthews-Juarez P, Hood DB, Im W, Levine RS, Kilbourne BJ, et al. (December 2014). "The public health exposome: a population-based, exposure science approach to health disparities research". International Journal of Environmental Research and Public Health. 11 (12): 12866–12895. doi: 10.3390/ijerph111212866 . PMC   4276651 . PMID   25514145.
  41. ↑ Nuckols JR, Ward MH, Jarup L (June 2004). "Using geographic information systems for exposure assessment in environmental epidemiology studies". Environmental Health Perspectives. 112 (9): 1007–1015. doi:10.1289/ehp.6738. PMC   1247194 . PMID   15198921.
  42. ↑ Jerrett M, Burnett RT, Ma R, Pope CA, Krewski D, Newbold KB, et al. (November 2005). "Spatial analysis of air pollution and mortality in Los Angeles". Epidemiology. 16 (6): 727–736. doi: 10.1097/01.ede.0000181630.15826.7d . PMID   16222161. S2CID   24359763.
  43. ↑ Ohanyan H, Portengen L, Huss A, Traini E, Beulens JW, Hoek G, et al. (January 2022). "Machine learning approaches to characterize the obesogenic urban exposome". Environment International. 158: 107015. Bibcode:2022EnInt.15807015O. doi: 10.1016/j.envint.2021.107015 . PMID   34991269. S2CID   244874430.
  44. ↑ Schoene AM, Basinas I, van Tongeren M, Ananiadou S (July 2022). "A Narrative Literature Review of Natural Language Processing Applied to the Occupational Exposome". International Journal of Environmental Research and Public Health. 19 (14): 8544. doi: 10.3390/ijerph19148544 . PMC   9316260 . PMID   35886395.
  45. ↑ Patel CJ, Bhattacharya J, Butte AJ (May 2010). "An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus". PLOS ONE. 5 (5): e10746. Bibcode:2010PLoSO...510746P. doi: 10.1371/journal.pone.0010746 . PMC   2873978 . PMID   20505766.
  46. 1 2 Noor E, Cherkaoui S, Sauer U (June 2019). "Biological insights through omics data integration". Current Opinion in Systems Biology. 15: 39–47. doi:10.1016/j.coisb.2019.03.007. ISSN   2452-3100. S2CID   108376803.
  47. ↑ Dagnino S, Macherone A (2019). Unraveling the exposome: a practical view. Cham, Switzerland. ISBN   978-3-319-89321-1. OCLC   1057472095.{{cite book}}: CS1 maint: location missing publisher (link)
  48. ↑ Vineis P, Husgafvel-Pursiainen K (November 2005). "Air pollution and cancer: biomarker studies in human populations". Carcinogenesis. 26 (11): 1846–1855. doi: 10.1093/carcin/bgi216 . PMID   16123121.
  49. ↑ Nieuwenhuijsen MJ, Ristovska G, Dadvand P (October 2017). "WHO Environmental Noise Guidelines for the European Region: A Systematic Review on Environmental Noise and Adverse Birth Outcomes". International Journal of Environmental Research and Public Health. 14 (10): 1252. doi: 10.3390/ijerph14101252 . PMC   5664753 . PMID   29048350.
  50. ↑ Escher BI, Hackermüller J, Polte T, Scholz S, Aigner A, Altenburger R, et al. (February 2017). "From the exposome to mechanistic understanding of chemical-induced adverse effects". Environment International. 99: 97–106. Bibcode:2017EnInt..99...97E. doi:10.1016/j.envint.2016.11.029. PMC   6116522 . PMID   27939949.
  51. ↑ Liu K (January 2021). "Chemical contact tracing for exposomics". Exposome. 1 (1). doi: 10.1093/exposome/osac001 . ISSN   2635-2265.
  52. ↑ Andrianou X, Charisiadis P, Makris K (October 2019). "The urban exposome framework and a proof-of-concept study". Environmental Epidemiology. 3: 257–258. doi: 10.1097/01.ee9.0000608732.36531.e1 . ISSN   2474-7882. S2CID   208116561.
  53. ↑ Vrijheid M, Maitre L (2018-10-05), "Building an Early Life Exposome by Integrating Multiple Birth Cohorts: HELIX", Unraveling the Exposome, Cham: Springer International Publishing, pp. 393–404, doi:10.1007/978-3-319-89321-1_15, ISBN   978-3-319-89320-4, S2CID   92222002
  54. ↑ Patel CJ, Ioannidis JP (June 2014). "Studying the elusive environment in large scale". JAMA. 311 (21): 2173–2174. doi:10.1001/jama.2014.4129. PMC   4110965 . PMID   24893084.
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