 | This article is an autobiography or has been extensively edited by the subject or by someone connected to the subject.(June 2024) |
Federica Di Palma | |
|---|---|
| Alma mater | University of Reading |
| Scientific career | |
| Thesis | Analysis and mapping of bovine MHC class I genes (1999) |
Federica Di Palma is a scientist at Genome British Columbia. She is known for her work in genomics, data science, and biodiversity preservation.
Di Palma earned her Ph.D. in 1999 from the University of Reading, United Kingdom. She conducted postdoctoral work at the United States' National Institutes of Health and then moved to the University of New Hampshire in 2002. In 2006 she moved to the Broad Institute where she led the vertebrate biology group. [1] In 2014 Di Palma was named the director of science at The Genome Analysis Centre. [2] As of 2024 Di Palma is the chief scientific officer and vice president of research and innovation at Genome British Columbia. [3]
Di Palma's early work was a part of the Human Genome Project where she identified genes responsible for deafness syndromes in both mice and humans. [4] [5] She then worked on genome sequencing projects to examine evolution in the Caribbean anole lizard, [6] the cichlids of East African lakes, [7] and the three-spine stickleback. [8] Di Palma is part of a coalition working to expand science research in Columbia. [9]
The neutral theory of molecular evolution holds that most evolutionary changes occur at the molecular level, and most of the variation within and between species are due to random genetic drift of mutant alleles that are selectively neutral. The theory applies only for evolution at the molecular level, and is compatible with phenotypic evolution being shaped by natural selection as postulated by Charles Darwin.
In biology and genetics, the germline is the population of a multicellular organism's cells that develop into germ cells. In other words, they are the cells that form gametes, which can come together to form a zygote. They differentiate in the gonads from primordial germ cells into gametogonia, which develop into gametocytes, which develop into the final gametes. This process is known as gametogenesis.
Experimental evolution is the use of laboratory experiments or controlled field manipulations to explore evolutionary dynamics. Evolution may be observed in the laboratory as individuals/populations adapt to new environmental conditions by natural selection.
The Salamandroidea are a suborder of salamanders, referred to as advanced salamanders. The members of the suborder are found worldwide except for Antarctica, sub-Saharan Africa, and Oceania. They differ from suborder Cryptobranchoidea as the angular and prearticular bones in their lower jaws are fused, their trunk ribs are bicapitate, and all members use internal fertilization. The female is fertilized by means of a spermatophore, a sperm-containing cap placed by the male in her cloaca. The sperm is stored in spermathecae on the roof of the cloaca until it is needed at the time of oviposition.
The Cancer Genome Project is part of the cancer, aging, and somatic mutation research based at the Wellcome Trust Sanger Institute in the United Kingdom. It aims to identify sequence variants/mutations critical in the development of human cancers. Like The Cancer Genome Atlas project within the United States, the Cancer Genome Project represents an effort in the War on Cancer to improve cancer diagnosis, treatment, and prevention through a better understanding of the molecular basis of the disease. The Cancer Genome Project was launched by Michael Stratton in 2000, and Peter Campbell is now the group leader of the project. The project works to combine knowledge of the human genome sequence with high throughput mutation detection techniques.
Cadherin-23 is a protein that in humans is encoded by the CDH23 gene.
Gap junction beta-6 protein (GJB6), also known as connexin 30 (Cx30) — is a protein that in humans is encoded by the GJB6 gene. Connexin 30 (Cx30) is one of several gap junction proteins expressed in the inner ear. Mutations in gap junction genes have been found to lead to both syndromic and nonsyndromic deafness. Mutations in this gene are associated with Clouston syndrome.
Haplotype convergence is the unrelated appearance of identical haplotypes in separate populations, through either convergent evolution or random chance.
Unconventional myosin-XV is a protein that in humans is encoded by the MYO15A gene.
Mucolipin-3 also known as TRPML3 is a protein that in humans is encoded by the MCOLN3 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.
Gene redundancy is the existence of multiple genes in the genome of an organism that perform the same function. Gene redundancy can result from gene duplication. Such duplication events are responsible for many sets of paralogous genes. When an individual gene in such a set is disrupted by mutation or targeted knockout, there can be little effect on phenotype as a result of gene redundancy, whereas the effect is large for the knockout of a gene with only one copy. Gene knockout is a method utilized in some studies aiming to characterize the maintenance and fitness effects functional overlap.
Periannan Senapathy is a molecular biologist, geneticist, author and entrepreneur. He is the founder, president and chief scientific officer at Genome International Corporation, a biotechnology, bioinformatics, and information technology firm based in Madison, Wisconsin, which develops computational genomics applications of next-generation DNA sequencing (NGS) and clinical decision support systems for analyzing patient genome data that aids in diagnosis and treatment of diseases.
Steve David Macleod Brown is a British geneticist who is director of the Medical Research Council (MRC) Mammalian Genetics Unit, MRC Harwell at Harwell Science and Innovation Campus, Oxfordshire, a research centre on mouse genetics. In addition, he leads the Genetics and Pathobiology of Deafness research group.
The Infinite sites model (ISM) is a mathematical model of molecular evolution first proposed by Motoo Kimura in 1969. Like other mutation models, the ISM provides a basis for understanding how mutation develops new alleles in DNA sequences. Using allele frequencies, it allows for the calculation of heterozygosity, or genetic diversity, in a finite population and for the estimation of genetic distances between populations of interest.
DNA transposons are DNA sequences, sometimes referred to "jumping genes", that can move and integrate to different locations within the genome. They are class II transposable elements (TEs) that move through a DNA intermediate, as opposed to class I TEs, retrotransposons, that move through an RNA intermediate. DNA transposons can move in the DNA of an organism via a single-or double-stranded DNA intermediate. DNA transposons have been found in both prokaryotic and eukaryotic organisms. They can make up a significant portion of an organism's genome, particularly in eukaryotes. In prokaryotes, TE's can facilitate the horizontal transfer of antibiotic resistance or other genes associated with virulence. After replicating and propagating in a host, all transposon copies become inactivated and are lost unless the transposon passes to a genome by starting a new life cycle with horizontal transfer. DNA transposons do not randomly insert themselves into the genome, but rather show preference for specific sites.
Aoife McLysaght is an Irish geneticist and a professor in the Molecular Evolution Laboratory of the Smurfit Institute of Genetics, Trinity College Dublin in Ireland.
Csaba Pal is a Hungarian biologist at the Biological Research Centre (BRC) in Szeged Hungary. His laboratory is part of the Synthetic and Systems Biology Unit at BRC. His research is at the interface of evolution, antibiotic resistance and genome engineering and has published over 80 scientific publications in these areas.
Alberto Bardelli is an Italian geneticist and cancer researcher, expert in the field of precision medicine. He is a full professor of histology at the Department of Oncology, University of Turin and Scientific Director of IFOM, the AIRC Institute of Molecular Oncology.
Susan Brawley is an American marine ecologist at the University of Maine known for her research on algae, especially algal reproduction. She was elected a fellow of the American Association for the Advancement of Science in 2012.
Brandon Stuart Gaut is an American evolutionary biologist and geneticist who works as a Distinguished Professor of Ecology and Evolutionary Biology at the University of California, Irvine.
| Authority control databases: Academics |
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