Adesina wrote for Vanguard Newspapers and National Concord Newspapers before joining the staff of The Sun Newspaper, where he rose to editor-in-chief. He also served a two-year term as president of the Nigerian Guild of Editors. Although re-elected for a second term as Guild president, Adesina stepped down after receiving his government appointment. He also stepped down as editor-in-chief of The Sun. Adesina was sworn-in as special adviser on media and publicity to Buhari on August 31, 2015 alongside Babachi Lawal, the incumbent Secretary to the Federal Government of Nigeria.