Ashley Sarmiento as Flor M. Maristela – Ida and Crisanto's daughter, Arnold and Beth's stepdaughter, and Liza's half-sister. She is a innocent little girl who befriends her half-sister Liza, who originally the girls are enemies before they are friends, Flor is very good at school, at the end of the series, she and Liza are saved by their father Crisanto, and she loses her mother Ida.
Rhed Bustamante as Liza P. Maristela – Beth and Crisanto's daughter, and Flor's half-sister. Originally, she argues with her half-sister Flor, but she becomes best friends with her after she apologized to her for what she did to her as Flor forgives her for everything, at the end of the series, she and Flor are saved by their father Crisanto.
Jolina Magdangal as Florida "Ida" Malubay-Magsakay — Crisanto's ex-mistress and Flor's mother. She dies at the end of the series, leaving Arnold and Flor.
Marvin Agustin as Crisanto Maristela — Flor & Liza’s father, Beth's husband, and Ida's ex-lover. At the end of the series, he saved Flor and Liza from Daisy.
Desiree del Valle as Elizabeth "Beth" S. Perez-Maristela — Crisanto’s wife, Liza’s mother, and Flor's stepmother. Originally, she hated Flor and wants her to stay away from Liza, but she apologized to her and loves her very much when Liza tries to argue with her, Beth is a very beautiful woman who supports Flor, at the end of the series, after her hair is cut, she consoled Flor about Ida's death.
Carlo Aquino as Arnold Magsakay — Florida's husband and Flor's stepfather. He becomes a widower to Flor after Ida dies at the end of the series.
Valerie Concepcion as Teacher Daisy C. Hizon — Flor and Liza's dance teacher who has an obsession over Flor and Crisanto. Recruits Liza into her plans by emotionally manipulating her into believing her parents love Flor more than her. She later unfollows Liza after Beth attempts to kick her out of the house, at the end of the series, she tried to kidnap Flor and Liza but Crisanto saved the little girls, defeating her.
Supporting cast
Elizabeth Oropesa as Lorena Sanchez-Perez — Beth's mother, Liza's grandmother, and Flor's step grandmother.
Tetchie Agbayani as Teresa Malubay — Florida's mother and Flor's grandmother.
Juan Rodrigo as Mariano "Nano" Perez — Beth's father, Liza's grandfather, and Flor's step grandfather who is a lung cancer survivor.
Tess Antonio as Annie — The rude, talkative, argumentative, and overly dramatic housemaid of the Maristela family. She prefers Flor more than Liza, who originally prefers her before Flor's arrival, she often argues with Rona.
Joey Paras as Rona — Beth's best friend who constantly argues with Annie. He cares deeply about Flor.
Edward Mendez as Manuel "Manny" S. Perez — Beth's unemployed younger brother.
Lemuel Pelayo as Jojo S. Perez — Beth's youngest brother.
Johan Santos as Miguel Fontanillas — Crisanto's friend.
Ronie "Atak" Arañia as Buslog Malubay — Teresa's adoptive son.
Dionne Monsanto as Lynette Nacianceno-Perez — Manny's kindhearted wife.
Lee Robin Salazar as Col. Francisco — Crisanto's best friend who was killed by the rebels.
Debraliz Borres as Bebeng Magsakay — Arnold's aunt.
Michael "Eagle" Riggs as Mama Wanda — Arnold's boss and the owner of the gay bar that Arnold works at.
Ricky Rivero as Lawrence "Lolei" Alcantara — Arnold's kindhearted customer from the gay bar who helps with his finances.
Wilma Doesnt as Dalisay Sulta — The manager of Lolei's department store.
JC Santos as Jason — Arnold's workmate who despises him.
Marco Pingol as Travis Marquez — Flor and Liza's neighbor and friend.
Bugoy Cariño as Luke Marquez — Travis' older brother, Flor and Liza's neighbor who is also their friend.
Carlo Maceda as Gener De Jesus — a man with a learning disability. He later befriends Flor.
JC Movido as Jenjen — Jason's autistic daughter.
Juvy Lyn Bison as Jenny Perez — Manny and Lynette's daughter.
Miguelito de Guzman as JC Perez — Manny and Lynette's son.
Guest cast
Kiko Matos as Cornelio Maristela — Crisanto's brother, who joined the rebels.
Initially meant to be part of ABS-CBN's PrimeTanghali noontime block, FlordeLiza was originally planned to replace Give Love on Christmas before It's Showtime. However, in a last-minute change, the timeslot was moved to be part of ABS-CBN's Kapamilya Gold afternoon block. The timeslot was after It's Showtime. Oh My G! was the one who took the timeslot before It's Showtime. It was moved to ABS-CBN's PrimeTanghali noontime block instead of the Primetime Bida evening block which the original timeslot is before TV Patrol which was the original plan.
It aired reruns on Jeepney TV from January 1 to April 19, 2018; March 28 to October 3, 2020; and March 17 to September 28, 2024.
International broadcasts
In Indonesia, the series was aired on RCTI in 2016, with Indonesian-dubbing.
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