The Frederick National Laboratory for Cancer Research (FNLCR) is one of the 18 United States National Laboratories and the only U.S. National Laboratory exclusively dedicated to biomedical research. [1] The Frederick National Laboratory is sponsored by NIH/National Cancer Institute (NCI) as a Federally Funded Research and Development Centers, [2] and its day-to-day operation is managed by the private contractor Leidos Biomedical Research for the NCI. The institution was originally established under the name NCI-Frederick Cancer Research Center in 1972 as a component of U.S. President Richard Nixon's War on Cancer initiative. In 2012, the institution received a National Laboratory designation and assumed its current name, becoming the only U.S. national laboratory dedicated entirely to biomedical research. The campus located within Fort Detrick U.S. Army Installation in Frederick, Maryland, also houses National Cancer Institute laboratories and administrative organizations, and is colloquially referred to as NCI-Frederick. [3] [4]
As part of the 1971 War on Cancer initiative, Richard Nixon requested that the United States Army transfer land and buildings which were then part of Fort Detrick to the Department of Health and Human Services in order to support the research efforts of the National Cancer Institute. The new laboratory was established in 1972 under the name "Frederick Cancer Research and Development Center" and received a designation as a Federally Funded Research and Development Center in 1975. This organizational model, also used by Lawrence Livermore National Laboratory and Los Alamos National Laboratory among others, specifies a type of public-private partnership composed of an institution that is owned by the federal government but operated by a private contractor. [3]
The laboratory was administratively reorganized in 1981, resulting in changing the name to "Frederick Cancer Research Center". In 2012, it was formally designated "Frederick National Laboratory for Cancer Research", becoming the first U.S. national laboratory owned by the Department of Health and Human Services and the only one exclusively dedicated to biomedical research. [3] [4] (HHS has since also established the CMS Alliance to Modernize Healthcare in cooperation with the Centers for Medicare and Medicaid Services. [5] ) The transition to redesignate FNLCR as a national laboratory was spearheaded by then-NCI director Harold Varmus. [6]
FNLCR currently operates a number of research programs and facilities designed to support National Institutes of Health research goals. FNLCR contains two pharmaceutical manufacturing facilities to support clinical trials run by the National Cancer Institute and the National Institute of Allergy and Infectious Diseases; manages a large collection of research samples, biological specimens, and mouse models used in cancer research; and hosts specific research projects such as the RAS Initiative, aimed at studying the biology of common oncogenes in the Ras subfamily, and the Nanotechnology Characterization Laboratory. [7]
Since 1995, the contractor operating the facility has been Leidos Biomedical Research (formerly SAIC-Frederick). [3] That contract was renewed for ten years in 2008. [8] In 2015 the NCI began seeking applications for a new contract expected to be awarded in January 2017; [8] however, this search was suspended in September 2016. [9]
In addition to the FNLCR, the Frederick biomedical research campus also houses NCI facilities such as research laboratories, administrative organizations, and the separate NCI Center for Cancer Research. The facilities are collectively known as NCI-Frederick but are administratively distinct. [3] [10]
The National Institutes of Health, commonly referred to as NIH, is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is now part of the United States Department of Health and Human Services. Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program.
A biosafety level (BSL), or pathogen/protection level, is a set of biocontainment precautions required to isolate dangerous biological agents in an enclosed laboratory facility. The levels of containment range from the lowest biosafety level 1 (BSL-1) to the highest at level 4 (BSL-4). In the United States, the Centers for Disease Control and Prevention (CDC) have specified these levels in a publication referred to as BMBL. In the European Union, the same biosafety levels are defined in a directive. In Canada the four levels are known as Containment Levels. Facilities with these designations are also sometimes given as P1 through P4, as in the term P3 laboratory.
Fort Detrick is a United States Army Futures Command installation located in Frederick, Maryland. Fort Detrick was the center of the U.S. biological weapons program from 1943 to 1969. Since the discontinuation of that program, it has hosted most elements of the United States biological defense program.
Leidos Holdings, Inc. is an American defense, aviation, information technology, and biomedical research company headquartered in Reston, Virginia, that provides scientific, engineering, systems integration, and technical services. Founded as Science Applications International Corporation (SAIC),[6] Leidos merged with Lockheed Martin's IT sector, Information Systems & Global Solutions, in August 2016 to create the defense industry’s largest IT services provider. The Leidos-Lockheed Martin merger is one of the biggest transactions thus far in the consolidation of the defense sector. Leidos contracts extensively with the Department of Defense, the Department of Homeland Security, and the Intelligence Community, as well as other U.S. government agencies and select commercial markets.
Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology. It is located in Laurel Hollow on Long Island, New York.
Harold Eliot Varmus is an American Nobel Prize-winning scientist. He is currently the Lewis Thomas University Professor of Medicine at Weill Cornell Medicine and a senior associate at the New York Genome Center.
The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship.
The United States Army Medical Research Institute of Infectious Diseases is the United States Army's main institution and facility for defensive research into countermeasures against biological warfare. It is located on Fort Detrick, Maryland, near Washington, D.C., and is a subordinate lab of the United States Army Medical Research and Development Command (USAMRDC), headquartered on the same installation.
The Jackson Laboratory is an independent, non-profit biomedical research institution which was founded by Clarence Cook Little in 1929. It employs over 3,000 employees in Bar Harbor, Maine; Sacramento, California; Farmington, Connecticut; Shanghai, China; and Yokohama, Japan. The institution is a National Cancer Institute-designated Cancer Center and has NIH Centers of Excellence in aging and systems genetics. The stated mission of The Jackson Laboratory is "to discover the genetic basis for preventing, treating and curing human diseases, and to enable research and education for the global biomedical community."
The National Biodefense Analysis and Countermeasures Center (NBACC) is a government biodefense research laboratory created by the U.S. Department of Homeland Security (DHS) and located at the sprawling biodefense campus at Fort Detrick in Frederick, MD, USA. The NBACC is the principal U.S. biodefense research institution engaged in laboratory-based threat assessment and bioforensics. NBACC is an important part of the National Interagency Biodefense Campus (NIBC) also located at Fort Detrick for the US Army, National Institutes of Health and the US Department of Agriculture.
The National Center for Research Resources (NCRR) was a center within the National Institutes of Health, a United States government agency. NCRR provided funding to laboratory scientists and researchers for facilities and tools in the goal of curing and treating diseases.
Sanford Burnham Prebys is a 501(c)(3) non-profit medical research institute focused on basic and translational research, with major research programs in cancer, neurodegeneration, diabetes, infectious, inflammatory, and childhood diseases. The institute also specializes in stem cell research and drug discovery technologies.
Building 470 — also called the Pilot Plant, or sometimes “the Tower”, or “Anthrax Tower” — was a seven-story steel and brick building at Fort Detrick in Frederick, Maryland, United States, used in the small-scale production of biological warfare (BW) agents. The building, a Cold War era structure, was transferred from the Department of Defense to the National Cancer Institute-Frederick in 1988, to which it belonged until 2003 when it was demolished.
The United States Army Medical Research and Development Command (USAMRDC) is the United States Army's medical materiel developer, responsible for medical research, development, and acquisition.
The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC) is a National Cancer Institute (NCI)-designated comprehensive cancer center located in Baltimore, Maryland.
The NIH Intramural Research Program (IRP) is the internal research program of the National Institutes of Health (NIH), known for its synergistic approach to biomedical science. With 1,200 Principal Investigators and over 4,000 Postdoctoral Fellows conducting basic, translational, and clinical research, the NIH Intramural Research Program is the largest biomedical research institution on earth. The unique funding environment of the IRP facilitates opportunities to conduct both long-term and high-impact science that would otherwise be difficult to undertake. With rigorous external reviews ensuring that only the most outstanding research secures funding, the IRP is responsible for many scientific accomplishments, including the discovery of fluoride to prevent tooth decay, the use of lithium to manage bipolar disorder, and the creation of vaccines against hepatitis, Hemophilus influenzae (Hib), and human papillomavirus (HPV). In addition, the IRP has also produced or trained 21 Nobel Prize-winning scientists.
The Pancreatic Cancer Action Network (PanCAN) is a United States–based 501(c)(3) charity that funds research, provides patient/caregiver support, conducts community outreach and advocates for increased federal research funding for those affected by pancreatic cancer.
The United States Biological Defense Program—in recent years also called the National Biodefense Strategy—refers to the collective effort by all levels of government, along with private enterprise and other stakeholders, in the United States to carry out biodefense activities.
The New York Genome Center (NYGC) is an independent 501(c)(3) nonprofit academic research institution in New York, New York. It serves as a multi-institutional collaborative hub focused on the advancement of genomic science and its application to drive novel biomedical discoveries. NYGC's areas of focus include the development of computational and experimental genomic methods and disease-focused research to better understand the genetic basis of cancer, neurodegenerative disease, and neuropsychiatric disease. In 2020, the NYGC also has directed its expertise to COVID-19 genomics research.
Wei-Shau Hu is an American geneticist specialized in HIV research, retroviral recombination, RNA packaging, and virus assembly. She is a senior investigator at the National Cancer Institute and head of the viral recombination section. She was an associate professor at West Virginia University.