GRIP domain

GRIP domain
structure of a complex of the golgin-245 grip domain with arl1
Identifiers
Symbol	GRIP
Pfam	PF01465
InterPro	IPR000237
SCOP2	1upt / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the GRIP domain is a conserved protein domain. The GRIP (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain is found in many large coiled-coil proteins. It has been shown to be sufficient for targeting to the Golgi. It contains a completely conserved tyrosine residue. ^{[1] [2] [3]}

References

1. Munro S, Nichols BJ (April 1999). "The GRIP domain - a novel Golgi-targeting domain found in several coiled-coil proteins". Curr. Biol. 9 (7): 377–80. Bibcode:1999CBio....9..377M. doi: 10.1016/S0960-9822(99)80166-3 . PMID   10209120. S2CID   14905585.
2. Barr FA (April 1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins". Curr. Biol. 9 (7): 381–4. Bibcode:1999CBio....9..381B. doi: 10.1016/S0960-9822(99)80167-5 . PMID   10209123. S2CID   14404566.
3. Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA (April 1999). "A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins". Curr. Biol. 9 (7): 385–8. Bibcode:1999CBio....9..385K. doi: 10.1016/S0960-9822(99)80168-7 . PMID   10209125. S2CID   14342088.

This article incorporates text from the public domain Pfam and InterPro: IPR000237