The United States is the largest donor of multilateral global health funds. [1] According to the Office of Management and Budget, the U.S. government contributes <1% of the federal budget for foreign aid including global health activities. [2] In 2023, the U.S. contributed 12.9 billion USD towards global health activities across several health verticals including HIV, Tuberculosis, Malaria and COVID-19. [3]
In 2024, total U.S. global health funding through regular appropriations reached approximately $12.3 billion in FY 2024, up from $5.4 billion in FY 2006. [4]
The allocations by the United States of over $110 billion, represents the largest investment ever made by any nation in a single disease. [5]
The U.S. began funding global HIV initiatives in 1986, with efforts increasing substantially in 2003 with the launch of the President’s Emergency Plan for AIDS Relief (PEPFAR) by U.S. President George W. Bush, the largest program dedicated to a single disease globally. PEPFAR accounts for the majority (89%) of U.S. global HIV funding, which includes support for UNAIDS and international HIV research. [6] Managed by the Department of State's Bureau for Global Health Security and Diplomacy, PEPFAR funding is detailed in annual congressional appropriations and also supports agencies like USAID, CDC, and DoD. The National Institutes of Health (NIH) also contributes to international HIV research. [7] From FY 2015 to FY 2024, global HIV funding represented 42%-50% of the U.S. global health budget, with FY 2024 allocations totaling $5.4 billion, including $4.9 billion for PEPFAR and $575 million for NIH research. [8]
The Biden administration recently announced a six percent cut to the PEPFAR budget for FY 2025 with a proposed budget $4.4 billion. [9]
The U.S. has participated in global malaria efforts since the 1950s and is currently the second largest donor, following the Global Fund to Fight AIDS, Tuberculosis and Malaria. The President’s Malaria Initiative (PMI), led by USAID and co-implemented with the CDC, drives U.S. malaria activities. Additional support comes from NIH and DoD. U.S. bilateral funding for malaria rose from $854 million in FY 2015 to about $1 billion in FY 2024, representing 9% of the U.S. global health budget. [10] Despite increases over the past decade, funding has stabilized in recent years.
The U.S. Agency for International Development (USAID) initiated a global tuberculosis (TB) control program in 1998, the U.S. has become one of the leading donors to global TB control. U.S. bilateral TB funding, managed by USAID, includes contributions to the TB Drug Facility and the Global Fund to Fight AIDS, Tuberculosis and Malaria. Over the past decade, U.S. funding for TB has significantly increased, rising from $242 million in FY 2015 to $406 million in FY 2024, [11] now comprising about 3% of the U.S. global health budget of 12.9 billion USD.
The Global Fund to Fight AIDS, Tuberculosis and Malaria is an independent, multilateral institution that funds HIV, TB, and malaria programs in low- and middle-income countries using contributions from public and private donors. The U.S., its largest donor since providing the founding contribution in 2001, includes these contributions as part of PEPFAR. [12] [13] However, U.S. contributions are subject to restrictions, including a funding match requirement. While U.S. contributions peaked at $2.0 billion in FY 2023, they decreased to $1.7 billion in FY 2024 due to these restrictions. [14] Additionally, the U.S. Congress allocated $3.5 billion in emergency funds in FY 2021 to mitigate COVID-19 impacts on HIV programs.
Global Fund investments have led to a 61% reduction in deaths from HIV, tuberculosis, and malaria since 2002, saving 65 million lives according to a 2024 analysis. [15] The Global Fund’s latest report highlights a 55% price reduction for bedaquiline, a key drug for treating drug-resistant tuberculosis, and a 25% drop in the cost of tenofovir disoproxil fumarate, lamivudine, and dolutegravir (TLD), the first-line treatment for HIV. [16] A new mosquito net, treated with a dual-active ingredient insecticide, is now 45% more effective against malaria. By leveraging its purchasing power, the Global Fund has been able to lower drug prices. It currently supports 25 million people on antiretroviral treatment, preventing 1.66 billion hospitalization days and 1.36 billion outpatient visits, saving about $85 billion. [17]
The U.S. has been involved in Maternal & Child Health (MCH) efforts since the 1960s and is the largest donor to global MCH activities. Funding, which includes support for polio eradication and contributions to Gavi, the Vaccine Alliance (GAVI), and UNICEF, is managed by USAID, CDC, and the State Department. From FY 2015 to FY 2024, MCH funding increased from $1.18 billion to $1.29 billion, driven mainly by increased allocations to GAVI and polio, while bilateral MCH funding remained steady. In FY 2024, MCH funding comprised 10% of the U.S. global health budget, making it the third largest category.
Dr. Ezekiel Emanuel, a senior advisor to President Obama in the early 2010s, recommended funding MCH initiatives at the expense of future funding increases for PEPFAR. Dr. Emanuel claimed that PEPFAR "is not the best use of international health funding," and "fails to address many of the developing world's most serious health issues." [18] Anand Reddi and Sarah Leeper rebutted Emanuel by stating "The idea that differing global health initiatives must compete with each other lacks not only ethical legitimacy but also scientific merit. Maternal and child health, need not to be framed in opposition to PEPFAR. Confronting illness in isolation -- whether by funding PEPFAR at the expense of programs that target maternal or child health or vice versa -- cannot be our way forward. We should be advocating for funding both PEPFAR and maternal and child health together instead of favoring one program over another." [19]
In 2024, the U.S. government announced a new $20 million PEPFAR Youth Initiative to combat HIV/AIDS among young people; the initiative aims to improve HIV prevention, testing, and treatment services, focusing on youth in high-burden countries and addressing gaps in care and support for young people living with HIV. [20]
The United States has provided an additional $17 million USD to support clade I mpox preparedness and response in Central and Eastern Africa. [21] This funding is focused on enhanced surveillance, risk communication, community engagement, laboratory supplies, diagnostics, clinical services, and vaccine planning. [22]
In 2024, U.S. Global Health Funding includes $10 million for the Global Health Worker Initiative, the first time Congress has provided funding for this initiative that increase education and training of healthcare workers in resource limited settings. [23]
The United States President's Emergency Plan For AIDS Relief (PEPFAR) is the global health funding by the United States to address the global HIV/AIDS epidemic and help save the lives of those suffering from the disease. The U.S. allocation of over $110 billion marks the largest investment by any country has ever made towards combating a single disease. Launched by U.S. President George W. Bush in 2003, as of May 2020, PEPFAR has provided cumulative funding for HIV/AIDS treatment, prevention, and research since its inception, making it the largest global health program focused on a single disease in history until the COVID-19 pandemic. PEPFAR is implemented by a combination of U.S. government agencies in over 50 countries and overseen by the Global AIDS Coordinator at the United States Department of State. As of 2023, PEPFAR has saved over 25 million lives, primarily in sub-Saharan Africa.
The Global Fund to Fight AIDS, Tuberculosis and Malaria is an international financing and partnership organization that aims to "attract, leverage and invest additional resources to end the epidemics of HIV/AIDS, tuberculosis and malaria to support attainment of the Sustainable Development Goals established by the United Nations". This multistakeholder international organization maintains its secretariat in Geneva, Switzerland. The organization began operations in January 2002. Microsoft founder Bill Gates was one of the first donors to provide seed money for the partnership. From January 2006 it has benefited from certain US Privileges, Exemptions, and Immunities under executive order 13395, which conferred International Organizations Immunities Act status on it.
The European and Developing Countries Clinical Trials Partnership (EDCTP) is a partnership between the European Union (EU), Norway, Switzerland and developing countries and other donors, as well as the pharmaceutical industry, to enable clinical trials and the development of new medicines and vaccines against HIV/AIDS, tuberculosis, and malaria. The need for global action against these diseases in order to promote poverty reduction has been recognised by the United Nations, the G8, and the African Union, and the program envisioned the provision of €600 million for the period 2003–2007 in order to translate medical research results into clinical applications relevant to the needs of developing countries.
Unitaid is a global health initiative that works with partners to bring about innovations to prevent, diagnose and treat major diseases in low- and middle-income countries, with an emphasis on tuberculosis, malaria, and HIV/AIDS and its deadly co-infections. Founded in 2006, the organization funds the final stages of research and development of new drugs, diagnostics and disease-prevention tools, helps produce data supporting guidelines for their use, and works to allow more affordable generic medicines to enter the marketplace in low- and middle-income countries. Hosted by the World Health Organization (WHO) in Geneva, Unitaid was established by the governments of Brazil, Chile, France, Norway and the United Kingdom.
Global Action for Children (GAC) was a highly effective nonpartisan coalition dedicated to improving the lives of orphans and vulnerable children in the developing world active from 2004 - 2010.
The diplomatic relationship between the United States of America and Zambia can be characterized as warm and cooperative. Relations are based on their shared experiences as British colonies, both before, after and during the struggle for independence. Several U.S. administrations cooperated closely with Zambia's first president, Kenneth Kaunda, in hopes of facilitating solutions to the conflicts in Rhodesia (Zimbabwe), Angola, and Namibia. The United States works closely with the Zambian Government to defeat the HIV/AIDS pandemic that is ravaging Zambia, to promote economic growth and development, and to effect political reform needed to promote responsive and responsible government. The United States is also supporting the government's efforts to root out corruption. Zambia is a beneficiary of the African Growth and Opportunity Act (AGOA). The U.S. Government provides a variety of technical assistance and other support that is managed by the Department of State, U.S. Agency for International Development, Millennium Challenge Account (MCA) Threshold Program, Centers for Disease Control and Prevention, Department of Treasury, Department of Defense, and Peace Corps. The majority of U.S. assistance is provided through the President's Emergency Plan for AIDS Relief (PEPFAR), in support of the fight against HIV/AIDS.
Botswana–United States relations are the bilateral relations between Botswana and the United States.
Cases of HIV/AIDS in Peru are considered to have reached the level of a concentrated epidemic.
Eric Goosby is an American public health official, currently serving as Professor of Medicine and Director of the Center for Global Health Delivery, Diplomacy and Economics, Institute for Global Health Sciences at University of California, San Francisco. Dr. Goosby previously served as the UN Special Envoy on Tuberculosis as well as previously served as the United States Global AIDS Coordinator from 2009 until mid-November 2013. In the role, Goosby directed the U.S. strategy for addressing HIV around the world and led President Obama's implementation of the President's Emergency Plan for AIDS Relief (PEPFAR). Goosby was sworn in during June 2009 and resigned in November 2013, taking a position as a professor at UCSF, where he directs the Center for Global Health Delivery and Diplomacy, a collaboration between UCSF and the University of California, Berkeley.
The Millennium Foundation for Innovative Finance for Health is an independent, non-profit Swiss organization, established in November 2008 in order to create new ways to finance health systems in low- and middle-income countries. Based in Geneva, Switzerland, the Millennium Foundation aims to ensure that international commitments on improving health care are met through the development of innovative financing projects. Its first such project – called MassiveGood – was launched on 4 March, and will give travelers the possibility to add a $2, £2 or €2 micro-contribution to the purchase of a travel reservation, with all proceeds going to the fight against HIV/AIDS, malaria and tuberculosis.
Innovative financing refers to a range of non-traditional mechanisms to raise additional funds for development aid through "innovative" projects such as micro-contributions, taxes, public-private partnerships and market-based financial transactions.
Global Health Initiatives (GHIs) are humanitarian initiatives that raise and disburse additional funds for infectious diseases – such as AIDS, tuberculosis, and malaria – for immunizations and for strengthening health systems in developing countries. GHIs classify a type of global initiative, which is defined as an organized effort integrating the involvement of organizations, individuals, and stakeholders around the world to address a global issue.
The quality of health in Rwanda has historically been very low, both before and immediately after the 1994 genocide. In 1998, more than one in five children died before their fifth birthday, often from malaria. But in recent years Rwanda has seen improvement on a number of key health indicators. Between 2005 and 2013, life expectancy increased from 55.2 to 64.0, under-5 mortality decreased from 106.4 to 52.0 per 1,000 live births, and incidence of tuberculosis has dropped from 101 to 69 per 100,000 people. The country's progress in healthcare has been cited by the international media and charities. The Atlantic devoted an article to "Rwanda's Historic Health Recovery". Partners In Health described the health gains "among the most dramatic the world has seen in the last 50 years".
The Johns Hopkins Center for Communication Programs (CCP) was founded over 30 years ago by Phyllis Tilson Piotrow as a part the Johns Hopkins Bloomberg School of Public Health's department of Health, Behavior, and Society and is located in Baltimore, Maryland, United States.
The President's Malaria Initiative (PMI) is a U.S. Government initiative to control and eliminate malaria, one of the leading global causes of premature death and disability. The initiative was originally launched by U.S. president George W. Bush in 2005, and has been continued by each successive U.S. president.
The Catholic Medical Mission Board (CMMB) is an international, faith-based NGO, providing long-term, co-operative medical and development aid to communities affected by poverty and healthcare issues. It was established in 1912 and officially registered in 1928. CMMB is headquartered in New York City, USA, and currently has country offices in Haiti, Kenya, Peru, South Sudan, and Zambia.
This page is a timeline of global health, including major conferences, interventions, cures, and crises.
Global AIDS and Tuberculosis Relief Act of 2000 or Global AIDS Research and Relief Act of 2000 is a United States federal law establishing the World Bank AIDS Trust Fund for the care and prevention of HIV/AIDS and tuberculosis in overseas continents supporting substantial populations. The Act of Congress endorsed the International Bank for Reconstruction and Development and International Development Association to govern the financial fund for the global opportunistic infection epidemics.
Dr. Winnie Mpanju-Shumbusho is a Tanzanian paediatrician and public health leader who until December 31, 2015, served as World Health Organization (WHO) Assistant Director General for HIV/AIDS, Tuberculosis, Malaria and Neglected Tropical Diseases based in Geneva, Switzerland. From 2016 to 2019, she served as board chair of RBM Partnership To End Malaria. Before joining WHO in 1999, Mpanju-Shumbusho was Director General of The East, Central and Southern African Health Community (ECSA-HC) formerly known as the Commonwealth Regional Health Community for East, Central and Southern Africa (CRHC-ECSA).
American International Health Alliance (AIHA) is a nonprofit organisation aiming for assisting the global health. The organisation has managed more than 175 partnerships and project across the globe. In 2012, AIHA obtained the support of President's Emergency Plan for AIDS Relief [PEPFAR] project to strengthen the blood service in Central Asia, Ukraine, and Cambodia. Due to its structure based on the programmatic modal and dynamic condition, this organisation is suitable to assist the community or worldwide countries which have limited resources, and it is beneficial for sustainable evolution. AIHA is contributing to improve the worldwide health conditions. This organisation has been associated and largely contributed in the HIV-related area since 2000.