HMGXB3

Last updated
HMGXB3
Identifiers
Aliases HMGXB3 , HMGX3, SMF, HMG-box containing 3
External IDs MGI: 2441817 HomoloGene: 44229 GeneCards: HMGXB3
Gene location (Human)
Ideogram human chromosome 5.svg
Chr. Chromosome 5 (human) [1]
Human chromosome 5 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 5q32Start150,000,046 bp [1]
End150,053,142 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

22993

106894

Ensembl

ENSG00000113716

ENSMUSG00000024622

UniProt

Q12766
Q562E5

n/a

RefSeq (mRNA)

NM_014983

NM_134134
NM_178277

RefSeq (protein)

NP_055798
NP_055798.2

n/a

Location (UCSC) Chr 5: 150 – 150.05 Mb Chr 18: 61.13 – 61.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HMG-box containing 3 is a protein that in humans is encoded by the HMGXB3 gene. [5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Contents

Function

This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins.

Related Research Articles

ZNF3 protein-coding gene in the species Homo sapiens

Zinc finger protein 3 is a protein that in humans is encoded by the ZNF3 gene.

MTMR3 protein-coding gene in the species Homo sapiens

Myotubularin-related protein 3 is a protein that in humans is encoded by the MTMR3 gene.

SOX12 protein-coding gene in the species Homo sapiens

SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.

HMG20A protein-coding gene in the species Homo sapiens

High mobility group protein 20A is a protein that in humans is encoded by the HMG20A gene.

TOX protein-coding gene in the species Homo sapiens

Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene.

Collagen, type XXVIII, alpha 1 protein-coding gene in the species Homo sapiens

Collagen, type XXVIII, alpha 1 also known as COL28A1 is a protein that in humans is encoded by the COL28A1 gene. This protein belongs to a class of collagens that contain von Willebrand factor type A domains. The protein is encoded by the COL28A1 gene which contains 45 exons and is found of the p arm of chromosome 7.

ZBTB11 protein-coding gene in the species Homo sapiens

Zinc finger and BTB domain containing 11 is a protein that in humans is encoded by the ZBTB11 gene.

PRPF40B protein-coding gene in the species Homo sapiens

Pre-mRNA-processing factor 40 homolog B is a protein that in humans that is encoded by the PRPF40B gene.

HMGCS2 protein-coding gene in the species Homo sapiens

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) is an enzyme in humans that is encoded by the HMGCS2 gene.

SLC25A16 protein-coding gene in the species Homo sapiens

Solute carrier family 25, member 16 is a protein in humans that is encoded by the SLC25A16 gene.

WDHD1 protein-coding gene in the species Homo sapiens

WD repeat and HMG-box DNA binding protein 1 is a protein in humans that is encoded by the WDHD1 gene.

Inositol monophosphatase 3 protein-coding gene in the species Homo sapiens

Inositol monophosphatase 3 also known as inositol monophosphatase domain-containing protein 1 (IMPAD1) is an enzyme that in humans is encoded by the IMPAD1 gene.

Spla/ryanodine receptor domain and socs box containing 3 protein-coding gene in the species Homo sapiens

SplA/ryanodine receptor domain and SOCS box containing 3 is a protein that in humans is encoded by the SPSB3 gene.

MAB21L2 protein-coding gene in the species Homo sapiens

Mab-21-like 2 is a protein that in humans is encoded by the MAB21L2 gene.

TRIM69 protein-coding gene in the species Homo sapiens

Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene.

SOCS4 protein-coding gene in the species Homo sapiens

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.

Pleckstrin homology domain containing A4 protein-coding gene in the species Homo sapiens

Pleckstrin homology domain containing A4 is a protein that in humans is encoded by the PLEKHA4 gene.

HMG-box containing 4 protein-coding gene in the species Homo sapiens

HMG-box containing 4 is a protein that in humans is encoded by the HMGXB4 gene.

FOXS1 protein-coding gene in the species Homo sapiens

Forkhead box S1 is a protein that in humans is encoded by the FOXS1 gene.

MRPS9 protein-coding gene in the species Homo sapiens

Mitochondrial ribosomal protein S9 (MRPS9), otherwise known as uS9m, is a protein that in humans is encoded by the MRPS9 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113716 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024622 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: HMG-box containing 3" . Retrieved 2016-03-29.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

United States National Library of Medicine the worlds largest medical library, operated by the US federal government

The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library.

The public domain consists of all the creative works to which no exclusive intellectual property rights apply. Those rights may have expired, been forfeited, expressly waived, or may be inapplicable.


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.