Helen Lee Gruehl | |
|---|---|
 Helen Lee Gruehl, from the 1924 yearbook of Mount Holyoke College | |
| Born | December 20, 1902 Passaic, New Jersey, United States |
| Died | September 23, 1983 Concord, Massachusetts, United States |
| Other names | Helen Aikman |
| Occupation(s) | Biochemist, immunologist |
Helen Lee Gruehl Aikman (December 20, 1902 – September 1983) was an American immunologist.
Gruehl was born in Passaic, New Jersey, the daughter of Edward Charles Gruehl and Susan Ramsay Mason Gruehl. Her father was manager of a rubber factory; her mother was a teacher and clubwoman. [1] [2] Gruehl graduated from Passaic High School in 1920, and from Mount Holyoke College in 1924. [3] [4] Her major was chemistry, and her minor was in mathematics; she was also known as a dancer during her college years. [3] [5]
Gruehl taught in the immunology department of Bellevue Hospital Medical College, New York University, while doing research on anaphylaxis. [6] She co-authored over a dozen scientific articles on protein sensitivity, allergies and asthma. [7] Her work appeared in scholarly journals including Experimental Biology and Medicine, [8] [9] Journal of Immunology, [7] American Journal of Diseases of Children, [10] Journal of Clinical Investigation, [11] American Journal of Epidemiology , [12] and Archives of Pediatrics and Adolescent Medicine. [13]
Gruehl married building contractor Edgerton Ladd Aikman in 1930. [6] They had a daughter, Beverley. Her husband died in 1973, [22] and she died in 1983, in Concord, Massachusetts, at the age of 81. [23]
Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis. Symptoms may include red eyes, an itchy rash, sneezing, coughing, a runny nose, shortness of breath, or swelling. Note that food intolerances and food poisoning are separate conditions.
An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body. Such reactions are called allergies.
Anaphylaxis is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of the use of emergency medication on site. It typically causes more than one of the following: an itchy rash, throat closing due to swelling that can obstruct or stop breathing; severe tongue swelling that can also interfere with or stop breathing; shortness of breath, vomiting, lightheadedness, loss of consciousness, low blood pressure, and medical shock. These symptoms typically start in minutes to hours and then increase very rapidly to life-threatening levels. Urgent medical treatment is required to prevent serious harm and death, even if the patient has used an epipen or has taken other medications in response, and even if symptoms appear to be improving.
Hypersensitivity is an abnormal physiological condition in which there is an undesirable and adverse immune response to antigen. It is an abnormality in the immune system that causes immune diseases including allergies and autoimmunity. It is caused by many types of particles and substances from the external environment or from within the body that are recognized by the immune cells as antigens. The immune reactions are usually referred to as an over-reaction of the immune system and they are often damaging and uncomfortable.
Type I hypersensitivity, in the Gell and Coombs classification of allergic reactions, is an allergic reaction provoked by re-exposure to a specific type of antigen referred to as an allergen. Type I is distinct from type II, type III and type IV hypersensitivities. The relevance of the Gell and Coombs classification of allergic reactions has been questioned in the modern-day understanding of allergy, and it has limited utility in clinical practice.
Transforming growth factor is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.
Atopy is the tendency to produce an exaggerated immunoglobulin E (IgE) immune response to otherwise harmless substances in the environment. Allergic diseases are clinical manifestations of such inappropriate, atopic responses.
Wheat allergy is an allergy to wheat which typically presents itself as a food allergy, but can also be a contact allergy resulting from occupational exposure. Like all allergies, wheat allergy involves immunoglobulin E and mast cell response. Typically the allergy is limited to the seed storage proteins of wheat. Some reactions are restricted to wheat proteins, while others can react across many varieties of seeds and other plant tissues. Wheat allergy is rare. Prevalence in adults was found to be 0.21% in a 2012 study in Japan.
Human coronavirus 229E (HCoV-229E) is a species of coronavirus which infects humans and bats. It is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the APN receptor. Along with Human coronavirus OC43, it is one of the viruses responsible for the common cold. HCoV-229E is a member of the genus Alphacoronavirus and subgenus Duvinacovirus.
Apoatropine (atropatropine) is a member of class of tropane alkaloids. Chemically, it is an ester formed from tropine and atropic acid. Apoatropine can be found in plants of family Solanaceae. It is a bitter crystalline alkaloid. Examples of related tropane alkaloids include atropine, hyoscyamine, and hyoscine. Though apoatropine is found in various plants, it can also be prepared by the dehydration of atropine using nitric acid. Apoatropine is used as a pigment.
Mytatrienediol, also known as 16α-methyl-16β-epiestriol 3-methyl ether or 16β-hydroxy-16α-methylestradiol 3-methyl ether, is a synthetic steroidal estrogen medication and an estrogen ether which was derived from estriol and was developed for clinical use in the late 1950s but was never marketed. It was investigated as a weak and mildly estrogenic medication for men to treat atherosclerosis, improve serum lipid profiles, and reduce the risk of myocardial infarction. However, while preclinical research supported the profile of mytatriendiol as a weak estrogen, the medication was found in clinical trials to produce estrogenic side effects including feminization, breast pain, and gynecomastia in men similarly and comparably to other estrogens such as ethinylestradiol and conjugated estrogens, and its side effects ultimately precluded its use. The medication was also studied to treat bone pain in patients with multiple myeloma, metastatic bone disease, and osteoporosis, with effectiveness seen.
20β-Dihydroprogesterone (20β-DHP), also known as 20β-hydroxyprogesterone (20β-OHP), is an endogenous metabolite of progesterone which is formed by 20β-hydroxysteroid dehydrogenase (20β-HSD). It is a progestogen similarly to progesterone, with about 20 to 50% of the progestogenic activity of progesterone. It can be converted by 20β-HSD into progesterone in the uterus. The effects of 20β-HSD on the uterus, mammary glands, and in maintaining pregnancy have been studied. The progestogenic activity of 20β-HSD has also been characterized in women.
N,N-Dimethyl-2-chloro-2-phenylethylamine(DMEA) is chemical compound that irreversibly inhibits the acetylcholinesterase. DMEA can cause intoxication in cats, resulting from respiratory failure to death, and progressive damage to the central nervous system in rats. Synthesis of DMEA can be obtained by treating N,N-dimethyl-2-hydroxy-2-phenylethylamine with thionyl chloride (SOCl2). This compound, when dissolved water, decomposes into a highly reactive aziridinium ion, N,N-dimethyl-2-phenylaziridinium (DPA). DPA binds to the anionic site of acetylcholinesterase, where it alkylates and irreversibly inhibits the enzyme. DMEA was also compared to N, N-dimethyl, 2-chloro-2-phenyl-1-methylethyl-amine (M-DMEA) and the results show that there is a difference between the degree of adrenergic blocking activity and their immonium ring stability in vitro.
Irene L. Beland was an American nursing educator and patient-centered care researcher.
John Howard Mueller was an American biochemist, pathologist, and bacteriologist. He is known as the discoverer of the amino acid methionine in 1921, and as the co-developer, with Jane Hinton, of the eponymous Mueller–Hinton agar.
Henry Gray Barbour was an American physiologist and pharmacologist who served as a professor of pharmacology and toxicology at Yale University. He studied water exchange and metabolism associated with thermal control. He devised a standard technique for measuring the specific gravity of blood plasma. He found that heavy water decelerated metabolic activities in animals.
Asthma triggers are factors or stimuli that provoke the exacerbation of asthma symptoms or increase the degree of airflow disruption, which can lead to an asthma attack. An asthma attack is characterized by an obstruction of the airway, hypersecretion of mucus and bronchoconstriction due to the contraction of smooth muscles around the respiratory tract. Its symptoms include a wide range of manifestations such as breathlessness, coughing, a tight chest and wheezing.
Isaac Ott was an American physician and a professor of physiology. A pioneer of experimental physiology in the United States, his influential Textbook of Physiology went into five editions during his lifetime. Ott conducted animal experiments and contributed to the understanding of the regulation of body temperature by the corpora striata in the brain, the role of fever, and the use of antipyretics in treatment.
Lillian Segal Root, best known as Lillian Segal, was an explorer known for her participation in William Beebe's 1925 Arcturus expedition where she examined how light was produced by deep sea fish.
Ida Therese Genther Schmidt was an American anatomist and biochemistry researcher, working in endocrinology and especially on the effects of radiation. She was on the faculty of the University of Cincinnati's medical school for 33 years, beginning in the 1930s. She co-authored research papers with Leo Loeb, Marie Agnes Hinrichs, and Chi Che Wang.
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