Helena Alexandrovna Timofeeff-Ressovsky | |
---|---|
Born | June 21, 1898 Moscow, Russia |
Died | April 29, 1973 74) Obinsk, USSR | (aged
Scientific career | |
Fields | Population genetics, radiation ecology |
Institutions | Kaiser Wilhelm Institute for Brain Research, Institute for Medical Radiology |
Helena Alexandrovna Timofeeff-Ressovsky (June 21, 1898 – April 29, 1973) was a Russian biologist known for her work in developmental and population genetics and radiation ecology.
Helena's father, Aleksandr Fidler, ran a private girls' school. She and her siblings (two brothers and six sisters) were well-educated; some of her sisters studied chemistry and musicology. Helena met her future husband, Nikolai Vladimirovich, while studying biology and zoology in Moscow. [1]
The couple had two sons, Dmitry (born 1923) and Andrei (born 1927). Accused of antifascist activities in Germany, Dmitry was arrested in 1943 and died in the concentration camp in Mauthausen. [2] Andrei became a physicist. [3]
Helena and Nikolai co-authored a dozen papers that shaped developmental genetics. Their studies of Drosophila funebris in the 1920s explored the concepts of penetrance and expressivity. In response to Muller's X-ray experiments in the late 1920s, they turned their attention to mutation and population genetics. [4] A 1927 paper provided the first experimental proof of concealed genetic variability. [5]
On the recommendation of N. K. Koltsov, director of Moscow's Institute of Experimental Biology, the Timofeef-Ressovskys were recruited by Oskar Vogt to work at Berlin's Kaiser Wilhelm Institute for Brain Research in 1925. Official reluctance to let the couple leave Russia and enter Germany were overcome in part due to Helena's German ancestry. [6] A number of other Russians, including Sergei R. Zarapkin and his family, technical assistant Natalie Kromm, and the Timofeeff-Ressovskys' nanny, were in residence at the Institute. [7] Berlin was a comfortable place for women in the sciences: Cécile and Marthe Vogt, Estera Tenenbaum, Stella Rose, Rosa Schragenheim, Irmgard Leux, and Gertrud Soeken also worked at the Institute. [8]
Following the Nazi rise to power in 1933, the political climate became increasingly uncomfortable in Germany. The Institute was pressured to dismiss foreigners, women, and Jews. Helena officially retired, though she continued to collaborate with her husband. [9] Despite the efforts of Nikolai and Oskar Vogt, Tenenbaum was forced out of the Institute (and country) in 1934; [10] facilitated by a research grant, Marthe Vogt left Germany in 1935. [11] The situation in the Soviet Union was perilous: members of Nikolai and Helena's families were arrested and some were killed. Colleagues warned against returning home; when ordered to do so in 1937, Nikolai refused. [12] He used competing offers from the United States to negotiate improved working conditions in his Berlin laboratory. [13]
Helena's eldest son was arrested by the Germans in 1943 and her husband by the Russians in 1945. Their fate remained uncertain, but Helena was able to continue working in Berlin while her younger son resumed his studies. From 1946-1947, she worked under Hans Nachtsheim at Berlin University's Zoological Institute. In 1947, she received word that Nikolai was alive, and in August Helena and Andrei joined him in the Urals. [14]
Helena once more worked as a researcher in a department headed by her husband, first in the Urals and then, for the last decade of her life, the Institute of Medical Radiology near Moscow. She continued her scientific work, though she received no salary and opportunities for publication were often limited by the secret nature of her work. [15] During this period, she worked on problems of radiation ecology and population genetics, though the study of genetics was generally disallowed in the Soviet Union until the mid-60s. She was part of the first group in the USSR to study Arabidopsis genetics. [16]
Helena died in 1973; the loss was a serious blow for the husband whose scientific work and political travails had always overshadowed hers. [17] The Max Delbrück Center for Molecular Medicine hosts a lecture series named in Helena's honor. [18]
Max Ludwig Henning Delbrück was a German–American biophysicist who participated in launching the molecular biology research program in the late 1930s. He stimulated physical scientists' interest into biology, especially as to basic research to physically explain genes, mysterious at the time. Formed in 1945 and led by Delbrück along with Salvador Luria and Alfred Hershey, the Phage Group made substantial headway unraveling important aspects of genetics. The three shared the 1969 Nobel Prize in Physiology or Medicine "for their discoveries concerning the replication mechanism and the genetic structure of viruses". He was the first physicist to predict what is now called Delbrück scattering.
Nikolay Vladimirovich Timofeev-Ressovsky was a Soviet biologist who, in principle, was a senior scientist in Soviet programs of nuclear and, later in biological weapons. He conducted research in radiation genetics, experimental population genetics, and microevolution. His life was highlighted by scientific achievements in the face of severe personal hardship, including his imprisonment and working in secret scientific facilities of Soviet Gulag.
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Nikolai Konstantinovich Koltsov was a Russian biologist and a pioneer of modern genetics. Among his students were Nikolay Timofeeff-Ressovsky, Vladimir Pavlovich Efroimson, A.S. Serebrovsky, and Nikolay Dubinin. Along with his students, he demonstrated the fine structure of genes, and examined the structure of the cell and pioneered the idea of a cytoskeleton. His career was cut short in Stalinist Russia after being falsely accused of supporting scientific racism. He died unexpectedly following government persecution and there are allegations that he was executed.
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