Hilmar Bading

Last updated
Hilmar Bading
Born (1958-11-03) November 3, 1958 (age 66)
NationalityGerman
Alma mater Ruprecht-Karls-University Heidelberg
Scientific career
Fields Neurobiology, calcium cell signaling
Institutions Ruprecht-Karls-University Heidelberg
Academic advisorsWilhelm Hasselbach, Michael E. Greenberg
Hilmar Bading in 2014 HilmarBading.jpg
Hilmar Bading in 2014

Hilmar Bading (born 1958) is a German physician and neuroscientist. He is a member of the German National Academy of Science Leopoldina. [1]

Contents

Education and career

Hilmar Bading studied medicine from 1978 to 1984 at Heidelberg University (MD in 1984) and carried out his MD Thesis at the Max Planck Institute for Medical Research, Heidelberg on calcium transport ATPase in skeletal muscle. He received postdoctoral training at the Max Planck Institute for Molecular Genetics in Berlin, Germany (1985–1989) and at Harvard Medical School, Boston, US (1989–1993). From 1993 to 2001 he was a staff scientist at the MRC Laboratory of Molecular Biology, Cambridge, UK. Since 2001 he has been professor of neurobiology and director of the Neurobiology Institute and the Interdisciplinary Center for Neurosciences (IZN) at Heidelberg University. [2] [3]

He is co-founder of FundaMental Pharma GmbH, Heidelberg. [4]

He founded the Foundation BrainAid. [5]

Research

Hilmar Bading's work is focused on neuronal calcium signaling and gene regulation in the nervous system. [6] He identified calcium as the principal second messenger in the coupling of neuronal activity to gene expression and characterized the processes that mediate the dialogue between the synapse and the nucleus. [7] [8] His work highlighted the spatial aspects of calcium signals [9] [10] and in particular the importance of nuclear calcium in governing activity-dependent gene expression and adaptations in the nervous system that include memory formation and acquired neuroprotection. [11] [12] [13] [14] The discovery of toxic signaling by extrasynaptic NMDA receptors which antagonizes gene regulation by synaptic activity and causes neuronal dysfunction and cell death [15] [16] contributed to the understanding of neurodegenerative disorders including Huntington's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). [15] [16] [17] [18] [19] [20]

Hilmar Bading and his co-workers uncovered the importance of a death signaling complex consisting of extrasynaptic NMDA receptors (NMDARs) and TRPM4 for excitotoxicity and identified a class of neuroprotective small molecules (known as NMDAR/TRPM4 interaction interface inhibitors or short ‚interface inhibitors‘) that disrupt the NMDAR/TRPM4 complex and protect against cell death in mouse models of stroke and retinal ganglion cell degeneration. [21]

Awards and honors

2001: Wolfgang-Paul Prize of the Alexander von Humboldt Foundation [22]

2016: Innovation Prize of the German BioRegions [23]

2019: Elected to the German National Academy of Science Leopoldina [1]

References

  1. 1 2 "List of Members". Nationale Akademie der Wissenschaften Leopoldina. Retrieved 2020-10-29.
  2. "Neurobiology". Heidelberg University. Retrieved 2016-10-18.
  3. "Interdisciplinary Center for Neurosciences (IZN)". Heidelberg University. Retrieved 2016-10-18.
  4. "www.fundamentalpharma.de". Fundamental Pharma. 2021-06-17.
  5. "Foundation Brainaid". www.foundationbrainaid.de. Retrieved 2020-10-29.
  6. Forschung, biotechnologie.de - Initiative des Bundesministeriums für Bildung und Forschung. "Biotechnologie.de - Menschen". www.biotechnologie.de (in German). Retrieved 2016-09-07.
  7. Bading, H.; Ginty, D. D.; Greenberg, M. E. (1993-04-09). "Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways". Science. 260 (5105): 181–186. Bibcode:1993Sci...260..181B. doi:10.1126/science.8097060. ISSN   0036-8075. PMID   8097060.
  8. Hagenston, Anna M.; Bading, Hilmar (2011-11-01). "Calcium signaling in synapse-to-nucleus communication". Cold Spring Harbor Perspectives in Biology. 3 (11): a004564. doi:10.1101/cshperspect.a004564. ISSN   1943-0264. PMC   3220353 . PMID   21791697.
  9. Ginty, D. D. (1997-02-01). "Calcium regulation of gene expression: isn't that spatial?". Neuron. 18 (2): 183–186. doi: 10.1016/s0896-6273(00)80258-5 . ISSN   0896-6273. PMID   9052789. S2CID   15833933.
  10. Hardingham, G. E.; Chawla, S.; Johnson, C. M.; Bading, H. (1997-01-16). "Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression". Nature. 385 (6613): 260–265. Bibcode:1997Natur.385..260H. doi:10.1038/385260a0. ISSN   0028-0836. PMID   9000075. S2CID   4328815.
  11. Bading, Hilmar (2013-09-01). "Nuclear calcium signalling in the regulation of brain function". Nature Reviews. Neuroscience. 14 (9): 593–608. doi:10.1038/nrn3531. ISSN   1471-0048. PMID   23942469. S2CID   14896252.
  12. "Heidelberg Researchers Identify Neuron Survival Programmes - University of Heidelberg". www.uni-heidelberg.de. Retrieved 2016-09-07.
  13. "Mediaserver – Universität Heidelberg: Audio". archiv.ub.uni-heidelberg.de. Retrieved 2016-09-07.
  14. Campus TV: Dem Langzeitgedächtnis auf der Spur , retrieved 2016-09-07
  15. 1 2 Milnerwood, Austen J.; Gladding, Clare M.; Pouladi, Mahmoud A.; Kaufman, Alexandra M.; Hines, Rochelle M.; Boyd, Jamie D.; Ko, Rebecca W.Y.; Vasuta, Oana C.; Graham, Rona K. (2010-01-28). "Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice". Neuron. 65 (2): 178–190. doi: 10.1016/j.neuron.2010.01.008 . ISSN   1097-4199. PMID   20152125. S2CID   12987037.
  16. 1 2 Talantova, Maria; Sanz-Blasco, Sara; Zhang, Xiaofei; Xia, Peng; Akhtar, Mohd Waseem; Okamoto, Shu-ichi; Dziewczapolski, Gustavo; Nakamura, Tomohiro; Cao, Gang (2013-07-02). "Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss". Proceedings of the National Academy of Sciences of the United States of America. 110 (27): E2518–2527. Bibcode:2013PNAS..110E2518T. doi: 10.1073/pnas.1306832110 . ISSN   1091-6490. PMC   3704025 . PMID   23776240.
  17. "Proteins Produced by Activated Neurons Could Protect Against Neurodegeneration". 2015-08-24. Retrieved 2016-09-07.
  18. Okamoto, Shu-ichi; Pouladi, Mahmoud A.; Talantova, Maria; Yao, Dongdong; Xia, Peng; Ehrnhoefer, Dagmar E.; Zaidi, Rameez; Clemente, Arjay; Kaul, Marcus (2009-12-01). "Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin". Nature Medicine. 15 (12): 1407–1413. doi:10.1038/nm.2056. ISSN   1546-170X. PMC   2789858 . PMID   19915593.
  19. Hardingham, Giles E.; Bading, Hilmar (2010-10-01). "Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders". Nature Reviews. Neuroscience. 11 (10): 682–696. doi:10.1038/nrn2911. ISSN   1471-0048. PMC   2948541 . PMID   20842175.
  20. Parsons, Matthew P.; Raymond, Lynn A. (2014). "Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders". Neuron. 82 (2): 279–293. doi: 10.1016/j.neuron.2014.03.030 . PMID   24742457.
  21. Yan, Jing; Bengtson, C. Peter; Buchthal, Bettina; Hagenston, Anna M.; Bading, Hilmar (9 October 2020). "Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants". Science. 370 (6513): eaay3302. doi:10.1126/science.aay3302. ISSN   1095-9203. PMID   33033186. S2CID   222210921.
  22. "The Wolfgang Paul Award". Alexander von Humboldt Foundation. Retrieved 2016-10-18.
  23. "Nasenspray gegen Nervenleiden, Organmodelle statt Tierversuche, Viren gegen Krebs: Innovationspreis der BioRegionen" [Nasal spray against nervous disorders, organ models instead of animal testing, virus against cancer: Innovation Award BioRegions]. Bio Deutschland (Press release) (in German). Retrieved 2016-10-18.