Nuclear calcium

Transmission electron micrograph of calcium content in the nucleus (N) and mitochondria (M) of a chondrocyte

The concentration of calcium in the cell nucleus can increase in response to signals from the environment. Nuclear calcium is an evolutionary conserved potent regulator of gene expression that allows cells to undergo long-lasting adaptive responses. The 'Nuclear Calcium Hypothesis' by Hilmar Bading describes nuclear calcium in neurons as an important signaling end-point in synapse-to-nucleus communication that activates gene expression programs needed for persistent adaptations. ^[1] In the nervous system, nuclear calcium is required for long-term memory formation, acquired neuroprotection, and the development of chronic inflammatory pain. ^{[2] [3] [4] [5]} In the heart, nuclear calcium is important for the development of cardiac hypertrophy. ^{[6] [7]} In the immune system, nuclear calcium is required for human T cell activation. ^[8] Plants use nuclear calcium to control symbiosis signaling. ^[9]

References

1. Bading, H. (2000-09-01). "Transcription-dependent neuronal plasticity: the nuclear calcium hypothesis". European Journal of Biochemistry. 267 (17): 5280–5283. doi: 10.1046/j.1432-1327.2000.01565.x . ISSN   0014-2956. PMID   10951185.
2. Weislogel, Jan-Marek; Bengtson, C. Peter; Müller, Michaela K.; Hörtzsch, Jan N.; Bujard, Martina; Schuster, Christoph M.; Bading, Hilmar (2013-05-07). "Requirement for nuclear calcium signaling in Drosophila long-term memory". Science Signaling. 6 (274): ra33. doi:10.1126/scisignal.2003598. ISSN   1937-9145. PMID   23652205. S2CID   7112258.
3. Zhang, Sheng-Jia; Zou, Ming; Lu, Li; Lau, David; Ditzel, Désirée A. W.; Delucinge-Vivier, Celine; Aso, Yoshinori; Descombes, Patrick; Bading, Hilmar (2009-08-01). "Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity". PLOS Genetics. 5 (8) e1000604. doi: 10.1371/journal.pgen.1000604 . ISSN   1553-7404. PMC   2718706 . PMID   19680447.
4. Simonetti, Manuela; Hagenston, Anna M.; Vardeh, Daniel; Freitag, H. Eckehard; Mauceri, Daniela; Lu, Jianning; Satagopam, Venkata P.; Schneider, Reinhard; Costigan, Michael (2013-01-09). "Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain". Neuron. 77 (1): 43–57. doi:10.1016/j.neuron.2012.10.037. ISSN   1097-4199. PMC   3593630 . PMID   23312515.
5. Bading, Hilmar (2013). "Nuclear calcium signalling in the regulation of brain function". Nature Reviews Neuroscience. 14 (9): 593–608. doi:10.1038/nrn3531. PMID   23942469. S2CID   14896252.
6. Higazi, Daniel R.; Fearnley, Claire J.; Drawnel, Faye M.; Talasila, Amarnath; Corps, Elaine M.; Ritter, Oliver; McDonald, Fraser; Mikoshiba, Katsuhiko; Bootman, Martin D. (2009-02-27). "Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes". Molecular Cell. 33 (4): 472–482. doi: 10.1016/j.molcel.2009.02.005 . ISSN   1097-4164. PMID   19250908.
7. Guatimosim, Silvia; Amaya, Maria Jimena; Guerra, Mateus T.; Aguiar, Carla J.; Goes, Alfredo M.; Gómez-Viquez, Norma Leticia; Rodrigues, Michele A.; Gomes, Dawidson A.; Martins-Cruz, Juliana (2008-08-01). "Nuclear Ca2+ regulates cardiomyocyte function". Cell Calcium. 44 (2): 230–242. doi:10.1016/j.ceca.2007.11.016. ISSN   0143-4160. PMID   18201761.
8. Monaco, Sara; Jahraus, Beate; Samstag, Yvonne; Bading, Hilmar (2016-10-24). "Nuclear calcium is required for human T cell activation". J Cell Biol. 215 (2): 231–243. doi:10.1083/jcb.201602001. ISSN   0021-9525. PMC   5084645 . PMID   27810914.
9. Oldroyd, Giles E. D.; Downie, J. Allan (2006-08-01). "Nuclear calcium changes at the core of symbiosis signalling". Current Opinion in Plant Biology. 9 (4): 351–357. Bibcode:2006COPB....9..351O. doi:10.1016/j.pbi.2006.05.003. ISSN   1369-5266. PMID   16713329.