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The Max Planck Institute for Molecular Genetics is a research institute for molecular genetics based in Berlin, Germany. It is part of the Max Planck Institute network of the Max Planck Society for the Advancement of Science.
Chromatin is a complex of DNA and protein found in eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in reinforcing the DNA during cell division, preventing DNA damage, and regulating gene expression and DNA replication. During mitosis and meiosis, chromatin facilitates proper segregation of the chromosomes in anaphase; the characteristic shapes of chromosomes visible during this stage are the result of DNA being coiled into highly condensed chromatin.
Regulome refers to the whole set of regulatory components in a cell. Those components can be regulatory elements, genes, mRNAs, proteins, and metabolites. The description includes the interplay of regulatory effects between these components, and their dependence on variables such as subcellular localization, tissue, developmental stage, and pathological state.
The Max Planck Institute of Biochemistry (MPIB) is a research institute of the Max Planck Society located in Martinsried, a suburb of Munich. The institute was founded in 1973 by the merger of three formerly independent institutes: the Max Planck Institute of Biochemistry, the Max Planck Institute of Protein and Leather Research, and the Max Planck Institute of Cell Chemistry.
Patrick Cramer is a German chemist, structural biologist, and molecular systems biologist. In 2020, he was honoured to be an international member of the National Academy of Sciences. He became president of the Max Planck Society in June 2023.
Polycomb-group proteins are a family of protein complexes first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place. Polycomb-group proteins are well known for silencing Hox genes through modulation of chromatin structure during embryonic development in fruit flies. They derive their name from the fact that the first sign of a decrease in PcG function is often a homeotic transformation of posterior legs towards anterior legs, which have a characteristic comb-like set of bristles.
A bivalent is one pair of chromosomes in a tetrad. A tetrad is the association of a pair of homologous chromosomes physically held together by at least one DNA crossover. This physical attachment allows for alignment and segregation of the homologous chromosomes in the first meiotic division. In most organisms, each replicated chromosome elicits formation of DNA double-strand breaks during the leptotene phase. These breaks are repaired by homologous recombination, that uses the homologous chromosome as a template for repair. The search for the homologous target, helped by numerous proteins collectively referred as the synaptonemal complex, cause the two homologs to pair, between the leptotene and the pachytene phases of meiosis I.
The Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany is an interdisciplinary research institute that conducts basic research in modern immunobiology, developmental biology and epigenetics. It was founded in 1961 as the Max Planck Institute of Immunobiology and is one of 86 institutions of the Max Planck Society. Originally named the Max Planck Institute of Immunobiology, it was renamed to its current name in 2010 as it widened its research thrusts to the study of epigenetics.
The Max Planck Institute of Molecular Plant Physiology is a German research institute for molecular plant physiology, based in the Golm district of Potsdam, Brandenburg. Founded on 1 January 1994, the MPIMP focuses on the study of the dynamics of plant metabolism and how that relates to the entire plant system. The institution is one of the 80 institutes in the Max Planck Society (Max-Planck-Gesellschaft).
Eugene Wimberly "Gene" Myers, Jr. is an American computer scientist and bioinformatician, who is best known for contributing to the early development of the NCBI's BLAST tool for sequence analysis.
Long non-coding RNAs are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs. Given that some lncRNAs have been reported to have the potential to encode small proteins or micro-peptides, the latest definition of lncRNA is a class of RNA molecules of over 200 nucleotides that have no or limited coding capacity. Long intervening/intergenic noncoding RNAs (lincRNAs) are sequences of lncRNA which do not overlap protein-coding genes.
The Wiley Prize in Biomedical Sciences is intended to recognize breakthrough research in pure or applied life science research that is distinguished by its excellence, originality and impact on our understanding of biological systems and processes. The award may recognize a specific contribution or series of contributions that demonstrate the nominee's significant leadership in the development of research concepts or their clinical application. Particular emphasis will be placed on research that champions novel approaches and challenges accepted thinking in the biomedical sciences.
The Max Planck Institute (MPI) for Biology of Ageing, founded in 2008, is one of over 80 independent, non-profit-making institutes set up under the umbrella of the Max Planck Society. The overall research aim is to obtain fundamental insights into the aging process and thus to pave the way towards healthier aging in humans. An international research team drawn from almost 30 nations is working to uncover underlying molecular, physiological and evolutionary mechanisms.
The Centre for Genomic Regulation is a biomedical and genomics research centre based on Barcelona. Most of its facilities and laboratories are located in the Barcelona Biomedical Research Park, in front of Somorrostro beach.
Martin Vingron is an Austrian mathematician working in the fields of bioinformatics and computational biology. Since 2000, he has been Director of the Max Planck Institute for Molecular Genetics.
Thomas Jenuwein is a German scientist working in the fields of epigenetics, chromatin biology, gene regulation and genome function.
Christoph Bock is a German bioinformatician and principal investigator at the Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences and a visiting professor at the Medical University of Vienna.
Asifa Akhtar is a Pakistani biologist who has made significant contributions to the field of chromosome regulation. She is Senior Group Leader and Director of the Department of Chromatin Regulation at the Max Planck Institute of Immunobiology and Epigenetics. Akhtar was awarded EMBO membership in 2013. She became the first international and female Vice President of the Max Planck Society's Biology and Medicine Section in July 2020.
Robert E. Kingston is an American biochemist who studies the functional and regulatory role nucleosomes play in gene expression, specifically during early development. After receiving his PhD (1981) and completing post-doctoral research, Kingston became an assistant professor at Massachusetts General Hospital (1985), where he started a research laboratory focused on understanding chromatin's structure with regards to transcriptional regulation. As a Harvard graduate himself, Kingston has served his alma mater through his leadership.
Wojciech Maciej Karlowski is a Polish biologist specializing in molecular biology and bioinformatics, and a full professor in biological sciences. He is Head of the Department of Computational Biology at the Faculty of Biology at the Adam Mickiewicz University in Poznan. His major scientific interests include identification of non-coding RNAs, genomics, high-throughput analyses, and functional annotation of biological sequences.
Eileen E. M. Furlong is an Irish molecular biologist working in the fields of transcription, chromatin biology, developmental biology and genomics. She is known for her work in understanding how the genome is regulated, in particular to how developmental enhancers function, how they interact within three dimensional chromatin topologies and how they drive cell fate decisions during embryogenesis. She is Head of the Department of Genome Biology at the European Molecular Biology Laboratory (EMBL). Furlong was elected a member of the European Molecular Biology Organization (EMBO) in 2013, the Academia Europaea in 2016 and to EMBO’s research council in 2018.
52°26′40″N13°16′22″E / 52.44444°N 13.27278°E
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