Human Biomolecular Atlas Program

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3 branches of HuBMAP: transformative technology development, the tissue mapping center and the HuBMAP integration, visualization and engagement. HubMap - Figure 1.png
3 branches of HuBMAP: transformative technology development, the tissue mapping center and the HuBMAP integration, visualization and engagement.

The Human Biomolecular Atlas Program (HuBMAP) is a program funded by the US National Institutes of Health to characterize the human body at single cell resolution, integrated to other efforts such as the Human Cell Atlas. [1] Among the products of the program is the Azimuth reference datasets for single-cell RNA seq data [2] [3] and the ASCT+B Reporter, a visualization tool for anatomical structures, cell types and biomarkers. [4] [5]

Millitomes are used to create uniformly sized tissue blocks that match the shape and size of organs from HuBMAP's 3D Reference Object Library. [6]

The HuBMAP received 27 million US dollars of funding from the NIH in 2020 and about 28.5 million in 2021. [7]

Technologies and approaches used by the HuBMAP consortium, including single-cell RNA sequencing and spatial trancriptomics. HubMap - Figure 3.png
Technologies and approaches used by the HuBMAP consortium, including single-cell RNA sequencing and spatial trancriptomics.

References

  1. 1 2 3 Snyder MP, Lin S, Posgai A, Atkinson M, Regev A, Rood J, et al. (HuBMAP Consortium) (October 2019). "The human body at cellular resolution: the NIH Human Biomolecular Atlas Program". Nature. 574 (7777): 187–192. Bibcode:2019Natur.574..187H. doi:10.1038/S41586-019-1629-X. PMC   6800388 . PMID   31597973.
  2. ↑ Hao Y, Hao S, Andersen-Nissen E, Mauck WM, Zheng S, Butler A, et al. (June 2021). "Integrated analysis of multimodal single-cell data". Cell. 184 (13): 3573–3587.e29. doi:10.1016/j.cell.2021.04.048. PMC   8238499 . PMID   34062119.
  3. ↑ "Azimuth". azimuth.hubmapconsortium.org. Archived from the original on 2022-07-06. Retrieved 2022-07-11.
  4. ↑ "ASCT+B Reporter". ccf-asctb-reporter-v2.netlify.app. Archived from the original on October 22, 2021. Retrieved 2022-07-11.
  5. ↑ Boppana A, Lee S, Malhotra R, Halushka M, Quardokus EM, Herr BW, Börner K, Weber GM (2022-03-01). "Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature". bioRxiv. doi: 10.1101/2022.02.28.482302 . S2CID   247231648.
  6. ↑ HIVE MC-IU Team. "HuBMAP: CCF Portal". hubmapconsortium.github.io. Retrieved 2022-08-27.
  7. ↑ "NIH Common Fund CONGRESSIONAL JUSTIFICATION FY 2022" (PDF). Archived (PDF) from the original on 2021-11-05. Retrieved 2022-07-11.


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