Hydrocholeretics are substances that increase the volume of secretion of bile from the liver without increasing the amount of solids secreted. [1] Some substances can result in decreased solid production, possibly due to circulatory effects. [2]
Cyclobutyrol is a compound commonly used as a hydrocholeretic. Its effects in rats include a dose-dependent increase in bile flow, sodium, potassium, chloride and bicarbonate outputs and reduced bile acid concentrations. [3]