IGF2-AS

IGF2-AS
Identifiers
Aliases	IGF2-AS , IGF2-AS1, PEG8, IGF2 antisense RNA
External IDs	OMIM: 610146 GeneCards: IGF2-AS
Gene location (Human)
Chr.	Chromosome 11 (human)
End	2,148,666 bp
RNA expression pattern
	Top expressed in
	placenta; ; right lobe of liver; ; stromal cell of endometrium; ; islet of Langerhans; ; face; ; tibial nerve; ; ganglionic eminence; ; left uterine tube; ; mouth; ; myometrium;
	n/a
	More reference expression data
	n/a
Orthologs
	51214
	n/a
	ENSG00000099869
	n/a
	n ; a
	n/a
	NM_016412
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated April 03, 2024

IGF2 antisense RNA is a protein that in humans is encoded by the IGF2-AS gene. ^[3]

Function

This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000099869 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: IGF2 antisense RNA" . Retrieved 2018-03-07.

Yang JM, Chen WS, Liu ZP, Luo YH, Liu WW (March 2003). "Effects of insulin-like growth factors-IR and -IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells". J. Gastroenterol. Hepatol. 18 (3): 296–301. doi:10.1046/j.1440-1746.2003.02961.x. PMID 12603530. S2CID 24390333.
Devaney JM, Hoffman EP, Gordish-Dressman H, Kearns A, Zambraski E, Clarkson PM (May 2007). "IGF-II gene region polymorphisms related to exertional muscle damage". J. Appl. Physiol. 102 (5): 1815–23. CiteSeerX 10.1.1.329.715 . doi:10.1152/japplphysiol.01165.2006. PMID 17289909. S2CID 2136915.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q (October 2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis. 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC 2722857 . PMID 18676680.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q (May 2009). "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China". Environ. Mol. Mutagen. 50 (4): 285–90. Bibcode:2009EnvMM..50..285S. doi:10.1002/em.20452. PMC 2666781 . PMID 19170196.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q (December 2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respir Med. 103 (12): 1866–70. doi:10.1016/j.rmed.2009.06.016. PMC 2783799 . PMID 19625176.
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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000099869 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: IGF2 antisense RNA" . Retrieved 2018-03-07.

[1]

[2]

[3]

IGF2-AS

Contents

Function

Related Research Articles

References

Further reading