IGHD

This article is about the human gene. For Isolated Growth Hormone Deficiency, see Growth hormone deficiency.

IGHD
Identifiers
Aliases	IGHD , immunoglobulin heavy constant delta
External IDs	OMIM: 147170; GeneCards: IGHD; OMA:IGHD - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.33 Start 105,836,765 bp [1] End 105,845,677 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node spleen granulocyte bone marrow cells appendix blood olfactory zone of nasal mucosa salivary gland tonsil minor salivary glands n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 3495 n/a Ensembl ENSG00000211898 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.84 – 105.85 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Ig delta chain C region is a protein that in humans is encoded by the IGHD gene. ^{[3] [4]}

References

1. GRCh38: Ensembl release 89: ENSG00000211898 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. White MB, Shen AL, Word CJ, Tucker PW, Blattner FR (May 1985). "Human immunoglobulin D: genomic sequence of the delta heavy chain". Science. 228 (4700): 733–7. doi:10.1126/science.3922054. PMID   3922054.
4. "Entrez Gene: IGHD immunoglobulin heavy constant delta".

Further reading

• Shin SU, Wei CF, Amin AR, et al. (1992). "Structural and functional properties of mouse-human chimeric IgD". Hum. Antibodies Hybridomas. 3 (2): 65–74. doi:10.3233/HAB-1992-3202. PMID   1633267.
• Roes J, Rajewsky K (1992). "Cell autonomous expression of IgD is not essential for the maturation of conventional B cells". Int. Immunol. 3 (12): 1367–71. doi:10.1093/intimm/3.12.1367. PMID   1838007.
• Shinoda T, Takahashi N, Takayasu T, et al. (1981). "Complete amino acid sequence of the Fc region of a human delta chain". Proc. Natl. Acad. Sci. U.S.A. 78 (2): 785–9. Bibcode:1981PNAS...78..785S. doi: 10.1073/pnas.78.2.785 . PMC   319887 . PMID   6785754.
• Lin LC, Putnam FW (1981). "Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function". Proc. Natl. Acad. Sci. U.S.A. 78 (1): 504–8. Bibcode:1981PNAS...78..504L. doi: 10.1073/pnas.78.1.504 . PMC   319082 . PMID   6787589.
• Putnam FW, Takahashi N, Tetaert D, et al. (1982). "Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD". Proc. Natl. Acad. Sci. U.S.A. 78 (10): 6168–72. doi: 10.1073/pnas.78.10.6168 . PMC   348999 . PMID   6947220.
• Takayasu T, Takahashi N, Shinoda T (1981). "Amino acid sequence and location of the three glycopeptides in the Fc region of human immunoglobulin D". Biochem. Biophys. Res. Commun. 97 (2): 635–41. doi:10.1016/0006-291X(80)90311-3. PMID   7008791.
• Takayasu T, Suzuki S, Kametani F, et al. (1982). "Amino acid sequence of galactosamine-containing glycopeptides in the hinge region of a human immunoglobulin D". Biochem. Biophys. Res. Commun. 105 (3): 1066–71. doi:10.1016/0006-291X(82)91078-6. PMID   7092891.
• Roes J, Rajewsky K (1993). "Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells". J. Exp. Med. 177 (1): 45–55. doi:10.1084/jem.177.1.45. PMC   2190865 . PMID   8418208.
• Scott IC, Halila R, Jenkins JM, et al. (1996). "Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1)". Gene. 174 (1): 135–43. doi:10.1016/0378-1119(96)00510-0. PMID   8863740.
• Zupo S, Cutrona G, Mangiola M, Ferrarini M (2002). "Role of surface IgM and IgD on survival of the cells from B-cell chronic lymphocytic leukemia". Blood. 99 (6): 2277–8. doi: 10.1182/blood-2001-11-0126 . PMID   11902141.
• Gala FA, Morrison SL (2002). "The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1". J. Biol. Chem. 277 (32): 29005–11. doi: 10.1074/jbc.M203258200 . PMID   12023968.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Schamel WW, Kuppig S, Becker B, et al. (2003). "A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9861–6. Bibcode:2003PNAS..100.9861S. doi: 10.1073/pnas.1633363100 . PMC   187866 . PMID   12886015.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Lee CE, Gaëta B, Malming HR, et al. (2006). "Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire". Immunogenetics. 57 (12): 917–25. doi:10.1007/s00251-005-0062-5. hdl: 1959.4/39531 . PMID   16402215. S2CID   29291806.
• Lee CE, Jackson KJ, Sewell WA, Collins AM (2007). "Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia". Leuk. Res. 31 (9): 1247–52. doi:10.1016/j.leukres.2006.10.013. PMID   17169423.
• Samuelsson M, Hallström T, Forsgren A, Riesbeck K (2007). "Characterization of the IgD binding site of encapsulated Haemophilus influenzae serotype b". J. Immunol. 178 (10): 6316–9. doi: 10.4049/jimmunol.178.10.6316 . PMID   17475860.