IGHG3

IGHG3
Identifiers
Aliases	IGHG3 , IgG3, immunoglobulin heavy constant gamma 3 (G3m marker)
External IDs	OMIM: 147120 GeneCards: IGHG3
Gene location (Human)
Chr.	Chromosome 14 (human)
End	105,771,405 bp
Orthologs
	3502
	n/a
	ENSG00000211897
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated October 17, 2022

Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene.^[3]^[4]

Related Research Articles

<span class="mw-page-title-main">Antibody</span> Protein(s) forming a major part of an organisms immune system

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope that is specific for one particular epitope on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly.

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene.

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.

Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the IGLL1 gene. IGLL1 has also recently been designated CD179B.

<span class="mw-page-title-main">IGHM</span> Gene in the species Homo sapiens

Ig mu chain C region is a protein that in humans is encoded by the IGHM gene.

<span class="mw-page-title-main">IGHG1</span>

Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene.

Immunoglobulin heavy constant alpha 1 is a immunoglobulin gene with symbol IGHA1. It encodes a constant (C) segment of Immunoglobulin A heavy chain. Immunoglobulin A is an antibody that plays a critical role in immune function in the mucous membranes. IgA shows the same typical structure of other antibody classes, with two heavy chains and two light chains, and four distinct domains: one variable region, and three variable regions. As a major class of immunoglobulin in body secretions, IgA plays a role in defending against infection, as well as preventing the access of foreign antigens to the immunologic system.

Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of human antibodies.

Ig delta chain C region is a protein that in humans is encoded by the IGHD gene.

Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene.

Ig gamma-2 chain C region is a protein that in humans is encoded by the IGHG2 gene.

CCAAT/enhancer-binding protein gamma is a protein that in humans is encoded by the CEBPG gene.

Ig alpha-2 chain C region is a protein that in humans is encoded by the IGHA2 gene.

Immunoglobulin lambda locus, also known as IGL@, is a region on the q arm of human chromosome 22, region 11.22 (22q11.22) that contains genes for the lambda light chains of antibodies.

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170.

Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene.

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.

Ig gamma-4 chain C region is a protein that in humans is encoded by the IGHG4 gene.

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.

Antibody structure is made up of two heavy-chains and two light-chains. These chains are held together by disulfide bonds. The arrangement or processes that put together different parts of this antibody molecule play important role in antibody diversity and production of different subclasses or classes of antibodies. The organization and processes take place during the development and differentiation of B cells. That is, the controlled gene expression during transcription and translation coupled with the rearrangements of immunoglobulin gene segments result in the generation of antibody repertoire during development and maturation of B cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000211897 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Alexander A, Steinmetz M, Barritault D, Frangione B, Franklin EC, Hood L, Buxbaum JN (Sep 1982). "gamma Heavy chain disease in man: cDNA sequence supports partial gene deletion model". Proc Natl Acad Sci U S A. 79 (10): 3260–4. Bibcode:1982PNAS...79.3260A. doi: 10.1073/pnas.79.10.3260 . PMC 346395 . PMID 6808505.
↑ "Entrez Gene: IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)".

Michaelsen TE, Frangione B, Franklin EC (1977). "Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit". J. Biol. Chem. 252 (3): 883–9. doi: 10.1016/S0021-9258(19)75181-3 . PMID 402363.
Wolfenstein-Todel C, Frangione B, Prelli F, Franklin EC (1976). "The amino acid sequence of "heavy chain disease" protein ZUC. Structure of the Fc fragment of immunoglobulin G3". Biochem. Biophys. Res. Commun. 71 (4): 907–14. doi:10.1016/0006-291X(76)90741-5. PMID 823945.
Huck S, Fort P, Crawford DH, et al. (1986). "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes". Nucleic Acids Res. 14 (4): 1779–89. doi:10.1093/nar/14.4.1779. PMC 339572 . PMID 3081877.
Frangione B, Rosenwasser E, Prelli F, Franklin EC (1980). "Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis". Biochemistry. 19 (18): 4304–8. doi:10.1021/bi00559a024. PMID 6774747.
Lewis AP, Lemon SM, Barber KA, et al. (1993). "Rescue, expression, and analysis of a neutralizing human anti-hepatitis A virus monoclonal antibody". J. Immunol. 151 (5): 2829–38. PMID 8395549.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000211897 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6808505-3] Alexander A, Steinmetz M, Barritault D, Frangione B, Franklin EC, Hood L, Buxbaum JN (Sep 1982). "gamma Heavy chain disease in man: cDNA sequence supports partial gene deletion model". Proc Natl Acad Sci U S A. 79 (10): 3260–4. Bibcode:1982PNAS...79.3260A. doi: 10.1073/pnas.79.10.3260 . PMC 346395 . PMID 6808505.

[entrez-4] "Entrez Gene: IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)".

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IGHG3

Related Research Articles

References

Further reading