ION LMD

Last updated
ION LMD
Acronym ION LMD means Image Oriented Navigation Laser Microdissection Device
Uses Isolation and collection of single cell or cells by laser cutting for further genetic analysis
Notable experiments

Choi JW, Kim DG, Lee AE, Kim HR, Lee JY, et al. (2011) Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis. PLoS Genet 7(3): e1001351. doi:10.1371/journal.pgen.1001351

Cao Z, Song JH, Kang YW, Yoon JH, Nam SW, et al. (2010) Genetic and Expression Analysis of the SIRT1 Gene in Gastric Cancers. J Gastric Cancer 10(3): 91-98.

Cho YG, Song JH, Kim CJ, Lee YS, Kim SY, et al. (2007) Genetic alterations of the ATBF1 gene in gastric cancer. Cli Cancer Res 13(15): 4355-9.

Contents

Manufacturer JungWoo F&B
Model ION LMD G1, ION LMD G2, ION LMD Pro

ION LMD system is one of the laser microdissection systems and a name of device that follows Gravity-Assisted Microdissection method, also known as GAM method. This non-contact laser microdissection system makes cell isolation for further genetic analysis possible. It is the first developed laser microdissection system in Asia.

Laser capture microdissection

Laser capture microdissection (LCM), also called microdissection, laser microdissection (LMD), or laser-assisted microdissection, is a method for isolating specific cells of interest from microscopic regions of tissue/cells/organisms.

Cell (biology) the basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

The cell is the basic structural, functional, and biological unit of all known living organisms. A cell is the smallest unit of life. Cells are often called the "building blocks of life". The study of cells is called cell biology or cellular biology.

Genetic analysis

Genetic analysis is the overall process of studying and researching in fields of science that involve genetics and molecular biology. There are a number of applications that are developed from this research, and these are also considered parts of the process. The base system of analysis revolves around general genetics. Basic studies include identification of genes and inherited disorders. This research has been conducted for centuries on both a large-scale physical observation basis and on a more microscopic scale. Genetic analysis can be used generally to describe methods both used in and resulting from the sciences of genetics and molecular biology, or to applications resulting from this research.

History

At first, proto type of ION LMD system was developed in 2004.
The first generation of ION LMD was developed in 2005 and then the second generation(so-called G2) was developed in 2008. At last, the third generation(so-called ION LMD Pro) was developed in 2012. [1]

Manufacturer

JungWoo F&B was founded in 1994, and offers various factory automation products for clients in semiconductor, consumer electronics, LCD, automotive manufacturing and ship-building industries. In 2003, the company entered the bio-mechanics business for the medical laboratory market and developed an ION LMD system which is utilized in cancer research. [2]

Automation use of various control systems for operating equipment

Automation is the technology by which a process or procedure is performed with minimal human assistance. Automation or automatic control is the use of various control systems for operating equipment such as machinery, processes in factories, boilers and heat treating ovens, switching on telephone networks, steering and stabilization of ships, aircraft and other applications and vehicles with minimal or reduced human intervention. Some processes have been completely automated.

A semiconductor material has an electrical conductivity value falling between that of a metal, like copper, gold, etc. and an insulator, such as glass. Their resistance decreases as their temperature increases, which is behaviour opposite to that of a metal. Their conducting properties may be altered in useful ways by the deliberate, controlled introduction of impurities ("doping") into the crystal structure. Where two differently-doped regions exist in the same crystal, a semiconductor junction is created. The behavior of charge carriers which include electrons, ions and electron holes at these junctions is the basis of diodes, transistors and all modern electronics. Some examples of semiconductors are silicon, germanium, and gallium arsenide. After silicon, gallium arsenide is the second most common semiconductor used in laser diodes, solar cells, microwave frequency integrated circuits, and others. Silicon is a critical element for fabricating most electronic circuits.

Consumer electronics Electronic equipment intended for everyday home use

Consumer electronics or home electronics are electronic equipments intended for everyday use, typically in private homes. Consumer electronics include devices used for entertainment, communications, and home-office activities. In British English, they are often called brown goods by producers and sellers, to distinguish them from "white goods" which are meant for housekeeping tasks, such as washing machines and refrigerators, although nowadays, these would be considered brown goods, some of these being connected to the Internet. In the 2010s, this distinction is not always present in large big box consumer electronics stores, such as Best Buy, which sell both entertainment, communication, and home office devices and kitchen appliances such as refrigerators.

Awards

This ION LMD system has got some reliable awards. [3]

Related Research Articles

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Inertial electrostatic confinement is a branch of fusion research that uses an electric field to elevate a plasma to fusion conditions. Electric fields can do work on charged particles, heating/confining them to fusion conditions. This is typically done in a sphere, with material moving radially inward, but can also be done in a cylindrical or beam geometry. The electric field can be generated using a wire grid or a non-neutral plasma cloud.

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Laser hair removal process of removing unwanted hair by means of exposure to pulses of laser light

Laser hair removal is the process of hair removal by means of exposure to pulses of laser light that destroy the hair follicle. It had been performed experimentally for about twenty years before becoming commercially available in 1995 and 1996. One of the first published articles describing laser hair removal was authored by the group at Massachusetts General Hospital in 1998. Laser hair removal is widely practiced in clinics, and even in homes using devices designed and priced for consumer self-treatment. Many reviews of laser hair removal methods, safety, and efficacy have been published in the dermatology literature.

Aneutronic fusion is any form of fusion power in which neutrons carry no more than 1% of the total released energy. The most-studied fusion reactions release up to 80% of their energy in neutrons. Successful aneutronic fusion would greatly reduce problems associated with neutron radiation such as ionizing damage, neutron activation and requirements for biological shielding, remote handling and safety.

Resonance-enhanced multiphoton ionization spectroscopy technique

Resonance-enhanced multiphoton ionization (REMPI) is a technique applied to the spectroscopy of atoms and small molecules. In practice, a tunable laser can be used to access an excited intermediate state. The selection rules associated with a two-photon or other multiphoton photoabsorption are different from the selection rules for a single photon transition. The REMPI technique typically involves a resonant single or multiple photon absorption to an electronically excited intermediate state followed by another photon which ionizes the atom or molecule. The light intensity to achieve a typical multiphoton transition is generally significantly larger than the light intensity to achieve a single photon photoabsorption. Because of this, a subsequent photoabsorption is often very likely. An ion and a free electron will result if the photons have imparted enough energy to exceed the ionization threshold energy of the system. In many cases, REMPI provides spectroscopic information that can be unavailable to single photon spectroscopic methods, for example rotational structure in molecules is easily seen with this technique.

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Gravity-assisted microdissection

Gravity-assisted microdissection(GAM) is one of the laser microdissection methods. The dissected material is allowed to fall by gravity into a cap and may thereafter be used for isolating proteins or genetic material. Two manufacturers in the world have developed their own device based on GAM method.

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References

  1. http://www.ionlmd.com
  2. http://www.biooscientific.com/DetailNews.aspx?itemId=62
  3. http://www.ionlmd.com