Iain McInnes

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Iain McInnes
CBE FRCPE FRCPGlas FMedSci FRSE
Born (1964-10-19) 19 October 1964 (age 59)
Glasgow, Scotland [1]
Alma materUniversity of Glasgow (BSc, MB ChB, PhD) [1]
Known forDirector of the Versus Arthritis Centre of Excellence for Inflammatory Arthritis
Awards FRCPE
FRCPGlas
FRSE (2008) [2]

FMedSci (2012) [3]

CBE (2019) [4]
Scientific career
Fields Rheumatology
Institutions University of Glasgow
Thesis Cytokine and nitric oxide production in inflammatory arthritis  (1996)
Doctoral advisor Prof. F.Y. Liew and Prof. Roger D. Sturrock
Website www.gla.ac.uk/schools/infectionimmunity/staff/iainmcinnes/

Iain Blair McInnes FRCPE FRCPGlas FMedSci FRSE (born 19 October 1964) is a Scottish rheumatologist, Vice Principal and Head of the College of Medical, Veterinary and Life Sciences, Muirhead Chair of Medicine and Versus Arthritis Professor of Rheumatology at the University of Glasgow. His research has focused on inflammatory diseases, particularly rheumatoid arthritis and psoriatic arthritis. [5]

Contents

His work has focused on new approaches and treatments for inflammatory diseases. Over two decades, he has been involved in clinical trials and pathogenesis investigation programs in inflammatory arthritis at an international level. His research has also explored the biology of inflammatory cytokines in arthritis and other inflammatory diseases, as well as the mechanisms of co-morbidities in chronic diseases. [6]

Research

McInnes's research has investigated the role of cytokines and their inflammation amplification role in immune-mediated inflammatory disease (IMID) pathogenesis. His early work focused on defining the roles played by novel cytokines in driving inflammatory synovitis, including the effector functions of IL-15, IL-18, and IL-33 in rheumatoid (RA) and psoriatic arthritis (PsA) synovitis. [7] [8] [9] His studies also examined the cytokine-driven cellular interactions between T cells, macrophages, and synovial fibroblasts, particularly the role of non-antigen dependent amplification of synovial inflammation. [10] [11]

Subsequently, his research identified several novel synovial cytokine amplificatory pathways involved in disease chronicity, such as PAR2 dependent matrix enzyme sensing [12] , and autoantibody to MICL mediated monocyte activation. [13] These studies have contributed to the understanding of the cellular and molecular mechanisms underlying inflammatory synovial disease. [14]

Roles

McInnes is Vice Principal and Head of the College of Medical, Veterinary and Life Sciences, Muirhead Chair of Medicine and Versus Arthritis Professor of Rheumatology at the University of Glasgow. [15]

He is past Chairman of the FOREUM (Foundation for European Rheumatology Research) Scientific Committee. From 2019 to 2021, he was President of EULAR [16] , the leading transnational society for rheumatology across Europe, during which time he founded the European Rheumatology Research Centre [17] , and established pan-European COVID-19 registries to define SARS-CoV-2 risk and vaccine efficacy across IMIDs. He chaired the UK Government’s Independent Advisory Group for strategies to support immune vulnerable patient groups during the COVID-19 pandemic. [18]

He is Director of the Versus Arthritis Centre of Excellence for Inflammatory Arthritis, led from Glasgow and including Universities of Oxford, Newcastle, and Birmingham. [19] He was Chief Investigator of the IMID-Bio-UK meta-consortium leading the UK effort to discover precision medicine tractable biomarkers for application in immune diseases. [20]

He is Associate Editor of Annals of the Rheumatic Diseases [21] and Editor in Chief of Firestein & Kelley's Textbook of Rheumatology. [22]

Boards and committees

Awards and Honours

McInnes was made of Commander of the Most Excellent Order of the British Empire (CBE) for services to medicine by Her Majesty the Queen in 2019. [30]

He is a Fellow of the Academy of Medical Sciences, a Fellow of the Royal Society of Edinburgh, and an Elected Member of Academia Europaea. [3] [2] [31] He is a Fellow of the Royal College of Physicians of Edinburgh and a Fellow of the Royal College of Physicians and Surgeons of Glasgow. [1]

He is the recipient of the Sir James Black Medal of the Royal Society of Edinburgh for "outstanding contribution to the field of immunology" (2017), [32] the Heberden Medal of the British Society for Rheumatology (2018), and the Carol-Nachman Prize for Rheumatology in Germany (2019). [33] Other awards include the Royal Philosophical Society of Glasgow's Thomas Graham Medal (2022) [34] , Tenovus Scotland's Lady Margaret McLellan Award (2016) [35] , the Laurentian Society’s JL Demers Award in Canada (2017) [36] , and the British Society for Rheumatology’s Michael Mason Prize (2001). [37]

Related Research Articles

<span class="mw-page-title-main">Arthritis</span> Type of joint disorder

Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some types of arthritis, other organs are also affected. Onset can be gradual or sudden.

<span class="mw-page-title-main">Rheumatoid arthritis</span> Type of autoimmune arthritis

Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. The disease may also affect other parts of the body, including skin, eyes, lungs, heart, nerves, and blood. This may result in a low red blood cell count, inflammation around the lungs, and inflammation around the heart. Fever and low energy may also be present. Often, symptoms come on gradually over weeks to months.

Rheumatology is a branch of medicine devoted to the diagnosis and management of disorders whose common feature is inflammation in the bones, muscles, joints, and internal organs. Rheumatology covers more than 100 different complex diseases, collectively known as rheumatic diseases, which includes many forms of arthritis as well as lupus and Sjögren's syndrome. Doctors who have undergone formal training in rheumatology are called rheumatologists.

<span class="mw-page-title-main">Psoriatic arthritis</span> Long-term inflammatory arthritis

Psoriatic arthritis (PsA) is a long-term inflammatory arthritis that occurs in people affected by the autoimmune disease psoriasis. The classic feature of psoriatic arthritis is swelling of entire fingers and toes with a sausage-like appearance. This often happens in association with changes to the nails such as small depressions in the nail (pitting), thickening of the nails, and detachment of the nail from the nailbed. Skin changes consistent with psoriasis frequently occur before the onset of psoriatic arthritis but psoriatic arthritis can precede the rash in 15% of affected individuals. It is classified as a type of seronegative spondyloarthropathy.

<span class="mw-page-title-main">Synovial fluid</span> Fluid found in the cavities of synovial joints

Synovial fluid, also called synovia,[help 1] is a viscous, non-Newtonian fluid found in the cavities of synovial joints. With its egg white–like consistency, the principal role of synovial fluid is to reduce friction between the articular cartilage of synovial joints during movement. Synovial fluid is a small component of the transcellular fluid component of extracellular fluid.

<span class="mw-page-title-main">Synovitis</span> Medical condition

Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that possess cavities, known as synovial joints. The condition is usually painful, particularly when the joint is moved. The joint usually swells due to synovial fluid collection.

<span class="mw-page-title-main">Golimumab</span> Pharmaceutical drug

Golimumab, sold under the brand name Simponi, is a human monoclonal antibody which is used as an immunosuppressive medication. Golimumab targets tumor necrosis factor alpha (TNF-alpha), a pro-inflammatory molecule and hence is a TNF inhibitor. Profound reduction in C-reactive protein (CRP) levels, interleukin (IL)-6, intercellaular adhesion molecules (ICAM)-1, matrix metalloproteinase (MMP)-3, and vascular endothelial growth factor (VEGF) demonstrates golimumab as an effective modulator of inflammatory markers and bone metabolism. Golimumab is given via subcutaneous injection.

Synovectomy is a procedure where the synovial tissue surrounding a joint is removed. This procedure is typically recommended to provide relief from a condition in which the synovial membrane or the joint lining becomes inflamed and irritated and is not controlled by medication alone. If arthritis is not controlled, it can lead to irreversible joint damage. The synovial membrane or "synovium" encloses each joint and also secretes a lubricating fluid that allows different joint motions such as rolling, folding and stretching. When the synovium becomes inflamed or irritated, it increases fluid production, resulting in warmth, tenderness, and swelling in and around the joint.

Osteoimmunology is a field that emerged about 40 years ago that studies the interface between the skeletal system and the immune system, comprising the "osteo-immune system". Osteoimmunology also studies the shared components and mechanisms between the two systems in vertebrates, including ligands, receptors, signaling molecules and transcription factors. Over the past decade, osteoimmunology has been investigated clinically for the treatment of bone metastases, rheumatoid arthritis (RA), osteoporosis, osteopetrosis, and periodontitis. Studies in osteoimmunology reveal relationships between molecular communication among blood cells and structural pathologies in the body.

<span class="mw-page-title-main">Rheumatoid nodule</span> Medical condition

A rheumatoid nodule is a lump of tissue, or an area of swelling, that appears on the exterior of the skin usually around the olecranon or the interphalangeal joints, but can appear in other areas. There are four different types of rheumatoid nodules: subcutaneous rheumatoid nodules, cardiac nodules, pulmonary nodules, and central nervous systems nodules. These nodules occur almost exclusively in association with rheumatoid arthritis. Very rarely do rheumatoid nodules occur as rheumatoid nodulosis in the absence of rheumatoid arthritis. Rheumatoid nodules can also appear in areas of the body other than the skin. Less commonly they occur in the lining of the lungs or other internal organs. The occurrence of nodules in the lungs of miners exposed to silica dust was known as Caplan’s syndrome. Rarely, the nodules occur at diverse sites on body.

<span class="mw-page-title-main">Anti–citrullinated protein antibody</span> Autoantibodies

Anti-citrullinated protein antibodies (ACPAs) are autoantibodies that are directed against peptides and proteins that are citrullinated. They are present in the majority of patients with rheumatoid arthritis. Clinically, cyclic citrullinated peptides (CCP) are frequently used to detect these antibodies in patient serum or plasma.

Sir Marc Feldmann,, is an Australian-educated British immunologist. He is a professor at the University of Oxford and a senior research fellow at Somerville College, Oxford.

Remitting seronegative symmetrical synovitis with pitting edema (or sometimes RS3PE) is a rare syndrome identified by symmetric polyarthritis, synovitis, acute pitting edema (swelling) of the back of the hands and/or feet, and a negative serum rheumatoid factor. If no underlying disorder can be identified (idiopathic RS3PE), this entity has an excellent prognosis and responds well to treatment.

A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes, thereby interfering with the JAK-STAT signaling pathway in lymphocytes.

<span class="mw-page-title-main">Enteropathic arthropathy</span> Medical condition

Enteropathic arthropathy commonly referred to as enteropathic arthritis, is a type of arthritis linked to Crohn's disease, ulcerative colitis, and chronic inflammatory bowel diseases.

<span class="mw-page-title-main">Secukinumab</span> Monoclonal antibody against IL-17

Secukinumab, sold under the brand name Cosentyx among others, is a human IgG1κ monoclonal antibody used for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. It binds to the protein interleukin (IL)-17A and is marketed by Novartis.

<span class="mw-page-title-main">Gary Firestein</span> American rheumatologist

Gary S. Firestein is an American rheumatologist, professor, and founding director of the Altman Clinical and Translational Research Institute (ACTRI) at the University of California San Diego and Senior Associate Vice Chancellor for Health Sciences at University of California, San Diego.

<span class="mw-page-title-main">Interleukin 40</span> Mammalian cytokine

Interleukin 40 (IL-40), also known with other name C17orf99, is a protein belonging to a group of cytokines called interleukins. It is encoded by a gene that does not belong to any cytokine superfamily. This cytokine is produced primarily by human expression tissues such as bone marrow and fetal liver, and its expression can be also induced in peripheral B cells after activation. IL-40 is involved in immunoglobulin A (IgA) production, and plays an important role in humoral immune responses and B cell homeostasis and development.

Fionula Brennan (1957–2012) was an Irish immunologist and Professor of Cytokine Immunopathology at the Kennedy Institute of Rheumatology.

<span class="mw-page-title-main">Josef Smolen</span> Austrian Rheumatologist

Josef Smolen is an Austrian rheumatologist and immunologist and professor emeritus at the Medical University of Vienna. Since 2018 he is chairman emeritus of the Department of Internal Medicine 3 and the Division of Rheumatology at the Medical University of Vienna and Vienna General Hospital and was the chairman of the 2nd Medical Department and Center for Diagnosis and Therapy of Rheumatic Diseases at the Lainz Hospital, now the Hietzing Clinic of the Vienna Health Association from 1989 to 2017.

References

  1. 1 2 3 "MCINNES, Prof. Iain Blair". Who's Who 2023, A & C Black, an Imprint of Bloomsbury Publishing PLC, 2023; Online Edn, Oxford University Press. doi:10.1093/ww/9780199540884.013.U267837.(subscription may be required or content may be available in libraries)
  2. 1 2 "Professor Iain McInnes". Royal Society of Edinburgh.
  3. 1 2 "Professor Iain McInnes - The Academy of Medical Sciences".
  4. ↑ "Who are the Scots on the Honours List?". BBC News. 29 December 2018.
  5. ↑ "University of Glasgow - Research - Glasgow Research Beacons - Precision Medicine & Chronic Diseases - Professor Iain McInnes". www.gla.ac.uk.
  6. ↑ "Professor Iain McInnes". acmedsci.ac.uk.
  7. ↑ McInnes, I. B.; Leung, B. P.; Sturrock, R. D.; Field, M.; Liew, F. Y. (1997). "Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis". Nature Medicine. 3 (2): 189–195. doi:10.1038/nm0297-189. PMID   9018238.
  8. ↑ Gracie, J. A.; Forsey, R. J.; Chan, W. L.; Gilmour, A.; Leung, B. P.; Greer, M. R.; Kennedy, K.; Carter, R.; Wei, X. Q.; Xu, D.; Field, M.; Foulis, A.; Liew, F. Y.; McInnes, I. B. (1999). "A proinflammatory role for IL-18 in rheumatoid arthritis". The Journal of Clinical Investigation. 104 (10): 1393–1701. doi:10.1172/JCI7317. PMC   409841 . PMID   10562301.
  9. ↑ Xu, D.; Jiang, H. R.; Li, Y.; Pushparaj, P. N.; Kurowska-Stolarska, M.; Leung, B. P.; Mu, R.; Tay, H. K.; McKenzie, A. N.; McInnes, I. B.; Melendez, A. J.; Liew, F. Y. (2010). "IL-33 exacerbates autoantibody-induced arthritis". Journal of Immunology (Baltimore, Md. : 1950). 184 (5): 2620–2626. doi:10.4049/jimmunol.0902685. PMID   20139274.
  10. ↑ McInnes, I. B.; Leung, B. P.; Liew, F. Y. (2000). "Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells". Arthritis Research. 2 (5): 374–378. doi: 10.1186/ar115 . PMC   130139 . PMID   11094451.
  11. ↑ McInnes, Iain B.; Schett, Georg (2007). "Cytokines in the pathogenesis of rheumatoid arthritis". Nature Reviews Immunology. 7 (6): 429–442. doi:10.1038/nri2094. PMID   17525752.
  12. ↑ Crilly, A.; Burns, E.; Nickdel, M. B.; Lockhart, J. C.; Perry, M. E.; Ferrell, P. W.; Baxter, D.; Dale, J.; Dunning, L.; Wilson, H.; Nijjar, J. S.; Gracie, J. A.; Ferrell, W. R.; McInnes, I. B. (2012). "PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis". Annals of the Rheumatic Diseases. 71 (6): 1049–1054. doi:10.1136/annrheumdis-2011-200703. PMC   4861243 . PMID   22294633.
  13. ↑ Redelinghuys, Pierre; Whitehead, Lauren; Augello, Andrea; Drummond, Rebecca A.; Levesque, Jean-Michel; Vautier, Simon; Reid, Delyth M.; Kerscher, Bernhard; Taylor, Julie A.; Nigrovic, Peter A.; Wright, John; Murray, Graeme I.; Willment, Janet A.; Hocking, Lynne J.; Fernandes, Maria J G.; De Bari, Cosimo; McInnes, Iain B.; Brown, Gordon D. (2016). "MICL controls inflammation in rheumatoid arthritis". Annals of the Rheumatic Diseases. 75 (7): 1386–1391. doi:10.1136/annrheumdis-2014-206644. PMID   26275430.
  14. ↑ "I McInnes".
  15. ↑ "AAD Reading Room | Iain McInnes, MD, on the Latest Findings on Bimekizumab for Psoriatic Arthritis | MedPage Today".
  16. ↑ "EULAR Message from the President, Professor Iain McInnes | Türkiye Romatizma Araştırma ve Savaş Derneği".
  17. ↑ Reuter, Katja; Haupt, Carina; Molto, Anna; Cope, Andrew; Van Vollenhoven, Ronald F.; Elewaut, Dirk; Lories, Rik; McInnes, Iain B. (2022). "Levelling the playing field of RMD research across Europe to address patients' needs: The emerging EULAR Research Centre". RMD Open. 8 (2): e002456. doi:10.1136/rmdopen-2022-002456. PMID   35714997.
  18. ↑ "Defining the highest-risk clinical subgroups upon community infection with SARS-CoV-2 when considering the use of neutralising monoclonal antibodies (NMABs) and antiviral drugs: Independent advisory group report".
  19. ↑ "Determined doctor's quest is inspired by patients' battles". 24 February 2014.
  20. ↑ "Universities to create world's largest inflammatory disease biobank".
  21. ↑ ""Professor Iain B McInnes - Eminent Consortium - UCL - University College London"". 25 February 2019.
  22. ↑ Firestein, Gary S.; Kelley, William N. (10 April 2024). "Kelley's Textbook of Rheumatology - ScienceDirect". Elsevier Health Sciences. ISBN   978-1-4377-1738-9.
  23. ↑ "Oversight Board". bioresource.nihr.ac.uk.
  24. ↑ "Experimental Medicine Panel". www.ukri.org.
  25. ↑ "Trustees and Co-optees". Versus Arthritis.
  26. ↑ "NHS Board Archives - Page 4 of 5 - NHSGGC".
  27. ↑ "EULAR 2021". www.esanum.fr.
  28. ↑ "FOREUM – Operational structure". www.foreum.org.
  29. ↑ "Scientific Committee".
  30. ↑ "Trio honoured for work at University of Glasgow". 29 December 2018.
  31. ↑ "Academy of Europe: McInnes Iain".
  32. ↑ "RSE Sir James Black Medal". Royal Society of Edinburgh.
  33. ↑ "UofG Professor awarded one of Germany's most prestigious medical prizes". www.gla.ac.uk.
  34. ↑ "Members' Newsletter Royal Philosophical Society" (PDF).
  35. ↑ "Tenovus Scotland".
  36. ↑ "Awards".
  37. ↑ Plenary Session (including the Michael Mason Prize winner) (Abstracts 179-185), Rheumatology, Volume 40, Issue suppl_1, April 2001, Pages 63–65
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