Ian Charles

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Ian Charles OBE is Director of the Quadram Institute in Norwich, UK. The Institute combines Quadram Institute Bioscience (the former Biotechnology and Biological Sciences Research Council (BBSRC) Institute of Food Research) and the endoscopy centre of the Norfolk and Norwich University Hospitals NHS Foundation Trust. It is closely allied with the University of East Anglia and the BBSRC. Charles' field of research is infectious diseases and the microbiome and its impact on health and well-being. [1]

Contents

Charles was an awarded an OBE in 2023. [2]

Career

Charles was a visiting professor at the University of Technology in Sydney. [3] He was also a professor of molecular biology at the University of Sheffield, and became the founding member of the Wolfson Institute for BioMedical Research at University College London in 19951. [4]

Charles founded two companies that discovers drugs against infection; Arrow Therapeutics sold to AstraZeneca in 2007, and Auspherix founded in 2013.

Selected publications

Charles' research interests lie in the areas of infectious diseases and the microbiome and their impact on human health.

Related Research Articles

<i>Vibrio cholerae</i> Species of bacterium

Vibrio cholerae is a species of Gram-negative, facultative anaerobe and comma-shaped bacteria. The bacteria naturally live in brackish or saltwater where they attach themselves easily to the chitin-containing shells of crabs, shrimp, and other shellfish. Some strains of V. cholerae are pathogenic to humans and cause a deadly disease called cholera, which can be derived from the consumption of undercooked or raw marine life species or drinking contaminated water.

<i>Vibrio</i> Genus of bacteria and the disease it can cause

Vibrio is a genus of Gram-negative bacteria, possessing a curved-rod (comma) shape, several species of which can cause foodborne infection or soft-tissue infection called Vibriosis. Infection is commonly associated with eating undercooked seafood. Being highly salt tolerant and unable to survive in freshwater, Vibrio spp. are commonly found in various salt water environments. Vibrio spp. are facultative anaerobes that test positive for oxidase and do not form spores. All members of the genus are motile. They are able to have polar or lateral flagellum with or without sheaths. Vibrio species typically possess two chromosomes, which is unusual for bacteria. Each chromosome has a distinct and independent origin of replication, and are conserved together over time in the genus. Recent phylogenies have been constructed based on a suite of genes.

<span class="mw-page-title-main">Mycobacteriaceae</span> Family of bacteria

Mycobacteriaceae is a family of bacteria in the phylum Actinomycetota. Its name is derived from the Mycobacterium genus, which includes pathogens known to cause serious diseases in mammals, including tuberculosis and leprosy in humans. The Greek prefix myco- means 'fungus', alluding to this genus' mold-like colony surfaces.

Microbial intelligence is the intelligence shown by microorganisms. This includes complex adaptive behavior shown by single cells, and altruistic or cooperative behavior in populations of like or unlike cells. It is often mediated by chemical signalling that induces physiological or behavioral changes in cells and influences colony structures.

Mycolicibacterium alvei is a species of the phylum Actinomycetota, belonging to the genus Mycolicibacterium.

Mycolicibacterium aubagnense is a species of the phylum Actinomycetota, belonging to the genus Mycolicibacterium.

Mycolicibacter nonchromogenicus is an infectious species of bacteria.

Mycolicibacillus trivialis is a species of Mycolicibacillus. It is known to cause relapsing peritonitis.

Oxalobacter vibrioformis is an oxalate-degrading anaerobic bacterium that was isolated from anoxic freshwater sediments. O. vibrioformis is a Gram-negative, non-spore-forming, motile, vibrioid rod which belongs to the genus Oxalobacter. O. vibrioformis uses oxalate and oxamate as its sole source of energy and acetate as its main source of carbon.

Candidatus Caballeronia kirkii is a Gram-negative, non-fermenting bacterium from the genus Caballeronia and the family Burkholderiaceae. Ca. C. kirkii is an endosymbiont of the plant Psychotria kirkii, also known as Rubiaceae, and exists inside leaf and stem nodules.

<span class="mw-page-title-main">Type VI secretion system</span> Bacterial molecular machine

The type VI secretion system (T6SS) is one of the bacterial secretion systems, membrane protein complexes, used by a wide range of gram-negative bacteria to transport effectors. Effectors are moved from the interior of a bacterial cell, across the membrane into an adjacent target cell. While often reported that the T6SS was discovered in 2006 by researchers studying the causative agent of cholera, Vibrio cholerae, the first study demonstrating that T6SS genes encode a protein export apparatus was actually published in 2004, in a study of protein secretion by the fish pathogen Edwardsiella tarda.

<i>Vampirovibrio chlorellavorus</i> Gram-negative bacteria, algae predator

Vampirovibrio chlorellavorus is a 0.6 μm pleomorphic cocci with a gram negative cell wall, and is one of the few known predatory bacteria. Unlike many bacteria, V. chlorellavorus is an obligate parasite, attaching to the cell wall of green algae of the genus Chlorella. The name Vampirovibrio originates from the Serbian vampir. meaning vampire and vibrio referring to the bacterial genus of curved rod bacterium. Chlorellavorus is named for the algal host of the bacterium (Chlorella) and the Latin voro meaning "to devour" (Chlorella-devouring).

Bacteroides dorei is a species of bacteria within the genus Bacteroides, first isolated in 2006. It is found in the intestinal systems of humans and animals. Research is being conducted to better understand the relationship Bacteroides dorei has on the human intestinal system and the autoimmune disease, Type 1 Diabetes (T1D).

Endozoicomonas is a genus of Gram-negative, aerobic or facultatively anaerobic, chemoorganotrophic, rod-shaped, marine bacteria from the family of Endozoicomonadaceae. Endozoicomonas are symbionts of marine animals.

Prabhu B. Patil is an Indian bacterial geneticist and a senior scientist at the Institute of Microbial Technology. Known for his studies on bacterial genetics, genomics and metagenomics, Patil has published his research findings by way of a number of articles; ResearchGate, an online repository of scientific articles has listed 95 of them. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2017–18.

<span class="mw-page-title-main">Natalie Prystajecky</span> Canadian biologist

Natalie Anne Prystajecky a Canadian biologist and the Environmental Microbiology program at the British Columbia Centre for Disease Control Public Health Laboratory. She holds a Clinical Assistant Professor position at the University of British Columbia. During the COVID-19 pandemic Prystajecky was involved with the development COVID-19 testing capabilities.

Gracilibacteria is a bacterial candidate phylum formerly known as GN02, BD1-5, or SN-2. It is part of the Candidate Phyla Radiation and the Patescibacteria group.

Mycolicibacter is a genus of gram-positive rod-shaped bacteria in the family Mycobacteriaceae from the order Mycobacteriales.

Mycolicibacillus is a genus of Gram-Positive rod-shaped bacteria in the family Mycobacteriaceae from the order Mycobacteriales.

Oxalobacter paraformigenes is a Gram negative, non-spore-forming, oxalate-degrading anaerobic bacterium that was first isolated from human fecal samples. O. paraformigenes may have a role in calcium oxalate kidney stone disease because of its unique ability to utilize oxalate as its primary carbon source.

References

  1. ↑ "Meet the man using 'omics technologies to answer global health questions". Eastern Daily Press. 2020-11-14. Retrieved 2023-10-05.
  2. ↑ "Professor honoured by the King for pioneering research". Eastern Daily Press. 2023-06-17. Retrieved 2023-10-05.
  3. ↑ "Ian Charles to Head the UK's Institute of Food Research". .foodingredientsfirst.com/. Retrieved 2023-10-05.
  4. ↑ "Ian Charles". University of East Anglia. Retrieved 4 January 2024.
  5. ↑ Gloag, Erin S.; Elbadawi, Christopher; Zachreson, Cameron J.; Aharonovich, Igor; Toth, Milos; Charles, Ian G.; Turnbull, Lynne; Whitchurch, Cynthia B. (2017). "Micro-Patterned Surfaces That Exploit Stigmergy to Inhibit Biofilm Expansion". Frontiers in Microbiology. 7: 2157. doi: 10.3389/fmicb.2016.02157 . ISSN   1664-302X. PMC   5253354 . PMID   28167929.
  6. ↑ Labbate, M; Orata, FD; Petty, NK; Jayatilleke, ND; King, WL; Kirchberger, PC; Allen, C; Mann, G; Mutreja, A; Thomson, NR; Boucher, Y; Charles, IG (2016). "A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules". Scientific Reports. 6: 36891. Bibcode:2016NatSR...636891L. doi: 10.1038/srep36891 . PMC   5109276 . PMID   27845364.
  7. ↑ Wyrsch, Ethan R.; Roy Chowdhury, Piklu; Chapman, Toni A.; Charles, Ian G.; Hammond, Jeffrey M.; Djordjevic, Steven P. (2016). "Genomic Microbial Epidemiology Is Needed to Comprehend the Global Problem of Antibiotic Resistance and to Improve Pathogen Diagnosis". Frontiers in Microbiology. 7: 843. doi: 10.3389/fmicb.2016.00843 . ISSN   1664-302X. PMC   4908116 . PMID   27379026.
  8. ↑ Joss, Tom V.; Burke, Catherine M.; Hudson, Bernard J.; Darling, Aaron E.; Forer, Martin; Alber, Dagmar G.; Charles, Ian G.; Stow, Nicholas W. (2016). "Bacterial Communities Vary between Sinuses in Chronic Rhinosinusitis Patients". Frontiers in Microbiology. 6: 1532. doi: 10.3389/fmicb.2015.01532 . ISSN   1664-302X. PMC   4722142 . PMID   26834708.
  9. ↑ Monahan, Leigh G.; Hajduk, Isabella V.; Blaber, Sinead P.; Charles, Ian G.; Harry, Elizabeth J. (July 2014). "Coordinating Bacterial Cell Division with Nutrient Availability: a Role for Glycolysis". mBio. 5 (3): e00935-14. doi:10.1128/mBio.00935-14. ISSN   2150-7511. PMC   4030479 . PMID   24825009.
  10. ↑ Wyrsch, Ethan; Chowdhury, Piklu Roy; Abraham, Sam; Santos, Jerran; Darling, Aaron E.; Charles, Ian G.; Chapman, Toni A.; Djordjevic, Steven P. (March 2015). "Comparative genomic analysis of a multiple antimicrobial resistant enterotoxigenic E. coli O157 lineage from Australian pigs". BMC Genomics. 16 (1): 165. doi: 10.1186/s12864-015-1382-y . ISSN   1471-2164. PMC   4384309 . PMID   25888127.
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