Igf like family member 3

Last updated
IGFL3
Identifiers
Aliases IGFL3 , UNQ483, IGF like family member 3
External IDs MGI: 2685426 HomoloGene: 74410 GeneCards: IGFL3
Gene location (Human)
Ideogram human chromosome 19.svg
Chr. Chromosome 19 (human) [1]
Human chromosome 19 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 19q13.32Start46,120,071 bp [1]
End46,124,674 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

388555

232925

Ensembl

ENSG00000188624

ENSMUSG00000066756

UniProt

Q6UXB1

Q6B9Z0

RefSeq (mRNA)

NM_207393

NM_001003393

RefSeq (protein)

NP_997276

NP_001003393

Location (UCSC) Chr 19: 46.12 – 46.12 Mb Chr 7: 18.18 – 18.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

IGF like family member 3 is a protein that in humans is encoded by the IGFL3 gene. [5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Contents

Function

IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188624 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066756 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: IGF like family member 3" . Retrieved 2016-03-20.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

United States National Library of Medicine the worlds largest medical library, operated by the US federal government

The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library.

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