Ijeoma Uchegbu | |
---|---|
Alma mater | University of Benin University of Lagos University of London |
Known for | Nanoparticle drug delivery |
Scientific career | |
Institutions | University of Strathclyde University College London |
Website | http://www.nanomerics.com |
Ijeoma Uchegbu is a Nigerian-British Professor of Pharmacy at University College London, where she held the position of Pro-Vice Provost for Africa and the Middle East. She is the Chief Scientific Officer of Nanomerics, a pharmaceutical nanotechnology company specialising in drug delivery solutions for poorly water-soluble drugs, nucleic acids and peptides. She is also a Governor of the Wellcome, a large biomedical research charity. [1] Apart from her highly cited scientific research in Pharmaceutical Nanoscience, [2] Uchegbu is also known for her work in science public engagement and equality and diversity in Science, Technology, Engineering and Mathematics (STEM). [3] [4] In December 2023, it was announced that she will become President of Wolfson College, Cambridge, in October 2024. [5]
Ijeoma Uchegbu grew up in Hackney, London, and South East Nigeria. [6] She studied pharmacy at the University of Benin, graduating in 1981, and earned her Masters degree at the University of Lagos, [7] but was unable to complete her PhD in Nigeria due to infrastructure difficulties in the 1980s.
"I came into science simply because after training as a pharmacist I wanted something a little bit more challenging to do. I thought that being a researcher would be a great place to start. As I did my pharmacy degree at Nigeria’s University of Benin, I did give research a try in Nigeria, but the infrastructure difficulties in the eighties made this virtually impossible. I came back to the UK, having emigrated 17 years earlier from the UK to Nigeria and started looking around for opportunities." [8]
She moved back to the UK and, as a mature student with three young children, [9] [10] completed her postgraduate studies at the University of London, graduating with a PhD in 1997. She was appointed a lecturer at the University of Strathclyde from 2002 to 2004.
Uchegbu has been elected President of Wolfson College, Cambridge, to take up the post commencing on 1 October 2024. [11]
Uchegbu was made a Chair in Drug Delivery at the University of Strathclyde in 2002. Here she worked on polymer self-assembly, identifying materials that could form stable nanosystems. [12] She demonstrated that polymer molecular weight could be used to control the size of vesicles. [13]
She joined University College London in 2006 as a Chair in Pharmaceutical Nanoscience at the School of Pharmacy. [14] [15] Uchegbu leads a research group that investigate molecular design and dosage of pharmaceuticals. [16] She has designed polymers that self-assemble into nanoparticles with the appropriate properties to transport drugs. [16] She explores how nanoparticles can be used for drug delivery. [17] Uchegbu holds several patents for drug delivery, [18] [19] [20] [21] [22] [23] [24] [25] and biocompatible polymers. [26] [27] [28] Her pharmaceuticals deliver genes and siRNA to tumours and peptides to the brain as well as encouraging the absorption of hydrophobic drugs using nanoparticles. [29] She is exploring how nanomedicine can be used to treat brain tumours. [30]
In 2018, she was part of a £5.7 million Engineering and Physical Sciences Research Council grant, Raman Nanotheranostics, that will use gold nanoparticles to identify disease and light to destroy diseased cells. [31] She also works with magnetic nanoparticles. [32] [33]
In 2010, Uchegbu with Andreas Schätzlein founded Nanomerics, [34] a pharmaceutical company that uses nanotechnology platforms to develop medicine. Uchegbu is the Chief Scientific Officer of Nanomerics, [12] developing structures that can transport antibodies that can cross the blood–brain barrier. [35] Nanomerics develop molecular envelope technology nanoparticles from amphiphilic polymers that self-assemble. [36] Uchegbu won the Royal Society of Chemistry Emerging Technologies prize for their molecular envelope technology in 2017. [37] .
Uchegbu serves on the editorial board of the Journal of Controlled Release . [38] She has served as the scientific secretary of the Controlled Release Society. She is editor-in-chief of Pharmaceutical Nanotechnology. [39] She is on the healthcare strategy advisory team of the Engineering and Physical Sciences Research Council. She was involved in the University College London celebrations of the National Health Service turning seventy. [40] In 2007, she was chosen for the Women of Outstanding Achievement in SET photographic exhibition that was displayed at the Science Museum and the British Museum. [41]
In 2015, Uchegbu was appointed Pro-Vice Provost for Africa and the Middle East. [42] [43] She chairs the Africa and Middle East regional network at University College London (UCL), building partnerships and starting collaborative teams, welcoming international visitors and supporting student recruitment. [44]
Uchegbu is involved in public engagement and science communication and featured on BBC Woman's Hour discussing her research into how nano particles can be used to help deliver drugs to the body [45] , BBC Radio 4's The Life Scientific [46] and taken part in Soapbox Science , an international science outreach programme promoting women scientists and the work they do to members of the public. [8]
Uchegbu is also involved in equality and diversity activities and programmes, acting as the UCL Provost's Envoy for Race Equality [4] and featuring as the only Black British Role Model for the Women's Engineering Society. [3] She also serves on the University College London Race Equality Charter self-assessment team. [47] [48] She is part of the Black Female Professors Forum, representing one of the 55 female professors of colour and one of the 25 Black female professors in the UK in 2017. [49] [50]
Dendrimers are highly ordered, branched polymeric molecules. Synonymous terms for dendrimer include arborols and cascade molecules. Typically, dendrimers are symmetric about the core, and often adopt a spherical three-dimensional morphology. The word dendron is also encountered frequently. A dendron usually contains a single chemically addressable group called the focal point or core. The difference between dendrons and dendrimers is illustrated in the top figure, but the terms are typically encountered interchangeably.
Targeted drug delivery, sometimes called smart drug delivery, is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug delivery. These nanoparticles would be loaded with drugs and targeted to specific parts of the body where there is solely diseased tissue, thereby avoiding interaction with healthy tissue. The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue. The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug side-effects, and reduced fluctuation in circulating drug levels. The disadvantage of the system is high cost, which makes productivity more difficult, and the reduced ability to adjust the dosages.
Modified-release dosage is a mechanism that delivers a drug with a delay after its administration or for a prolonged period of time or to a specific target in the body.
PEGylation is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated. PEGylation affects the resulting derivatives or aggregates interactions, which typically slows down their coalescence and degradation as well as elimination in vivo.
Kathryn Uhrich is Dean of the College of Natural and Agricultural Sciences, at The University of California, Riverside, and founder of Polymerix Corporation. She has received many awards for her research and work including the ACS Buck-Whitney Award and the Sioux Award. She was a fellow at both the National Academy of Inventors and the American Chemical Society in 2014.
Lipid-based nanoparticles are very small spherical particles composed of lipids. They are a novel pharmaceutical drug delivery system, and a novel pharmaceutical formulation. There are many subclasses of lipid-based nanoparticles such as: lipid nanoparticles (LNPs), solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs).
Smart polymers, stimuli-responsive polymers or functional polymers are high-performance polymers that change according to the environment they are in.
The UCL Faculty of Life Sciences is one of the 11 constituent faculties of University College London (UCL).
Nanoparticles for drug delivery to the brain is a method for transporting drug molecules across the blood–brain barrier (BBB) using nanoparticles. These drugs cross the BBB and deliver pharmaceuticals to the brain for therapeutic treatment of neurological disorders. These disorders include Parkinson's disease, Alzheimer's disease, schizophrenia, depression, and brain tumors. Part of the difficulty in finding cures for these central nervous system (CNS) disorders is that there is yet no truly efficient delivery method for drugs to cross the BBB. Antibiotics, antineoplastic agents, and a variety of CNS-active drugs, especially neuropeptides, are a few examples of molecules that cannot pass the BBB alone. With the aid of nanoparticle delivery systems, however, studies have shown that some drugs can now cross the BBB, and even exhibit lower toxicity and decrease adverse effects throughout the body. Toxicity is an important concept for pharmacology because high toxicity levels in the body could be detrimental to the patient by affecting other organs and disrupting their function. Further, the BBB is not the only physiological barrier for drug delivery to the brain. Other biological factors influence how drugs are transported throughout the body and how they target specific locations for action. Some of these pathophysiological factors include blood flow alterations, edema and increased intracranial pressure, metabolic perturbations, and altered gene expression and protein synthesis. Though there exist many obstacles that make developing a robust delivery system difficult, nanoparticles provide a promising mechanism for drug transport to the CNS.
Vladimir Petrovich Torchilin is a Soviet, Russian and American biochemist, pharmacologist, and an expert in medical nanotechnology. Torchillin is a University Distinguished Professor of Pharmaceutical Sciences at Northeastern University. He also serves as a director at both the Center for Translational Cancer Nanomedicine and at the Center for Pharmaceutical Biotechnology and Nanomedicine at Northeastern University.
Eugenia Eduardovna Kumacheva is a University Professor and Distinguished Professor of Chemistry at the University of Toronto. Her research interests span across the fields of fundamental and applied polymers science, nanotechnology, microfluidics, and interface chemistry. She was awarded the L'Oréal-UNESCO Awards for Women in Science in 2008 "for the design and development of new materials with many applications including targeted drug delivery for cancer treatments and materials for high density optical data storage". In 2011, she published a book on the Microfluidic Reactors for Polymer Particles co-authored with Piotr Garstecki. She is Canadian Research Chair in Advanced Polymer Materials. She is Fellow of the Royal Society (FRS) and a Fellow of the Royal Society of Canada (FRSC).
Andreas Bernkop-Schnürch is an Austrian scientist and entrepreneur, who is Head of the Department of Pharmaceutical Technology in the Institute of Pharmacy at the University of Innsbruck.
Dr. Jiban Jyoti Panda is an Indian scientist specializing in the field of nano-biotechnology. She has been awarded numerous awards in recognition for her work including the UNESCO - L`Oreal For Women in Science Fellowship, which recognizes the achievements of exceptional women across the globe.
Mojisola Christianah Adeyeye is a Nigerian pharmacist and professor. She was appointed the Director-General of National Agency for Food and Drug Administration and Control (NAFDAC) on 3 November 2017 by the President of The Federal Republic of Nigeria, Muhammadu Buhari. Before her appointment as NAFDAC boss, she was the founding Chair of Biopharmaceutical Sciences and a Professor of Pharmaceutics, Manufacturing Science and Drug Product Evaluation at the College of Pharmacy, Roosevelt University in Schaumburg, Illinois, where she spent 7 years. She was also a Professor of Pharmaceutics and Manufacturing for 21 years at Duquesne University in Pittsburgh, Pennsylvania, USA. She is Senior Fulbright Scholar and Specialist and 2008 American Association of Pharmaceutical Scientists Fellow. She is also a Fellow of the Nigerian Academy of Science and Nigeria Academy of Pharmacy. Her research interests are in the areas of pre-formulation, early phase development of solid, semisolid and liquid dosage forms, and IND-based and intellectual property-driven late phase drug product development. She is the founder and President of Elim Pediatric Pharmaceuticals Rolling Meadows, Illinois. Through Duquesne University, she was able to develop an anti-retroviral (HIV/AIDS) pediatric fixed-dose combination and received intellectual property on the formulations in the UK and South Africa.
Christine Allen is a Canadian professor and the first associate vice-president and vice-provost for strategic initiatives at the University of Toronto. She served formerly as interim dean of the university's Leslie Dan Faculty of Pharmacy. She is co-founder of Nanovista, a company focused on imaging of tumors. She also works as the associate editor of Molecular Pharmaceutics.
Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Recently, nanoparticles have aroused attention due to their potential application for effective drug delivery.
Hamid Ghandehari is an Iranian-American drug delivery research scientist, and a professor in the Departments of Pharmaceutics and Pharmaceutical Chemistry and Biomedical Engineering at the University of Utah. His research is focused in recombinant polymers for drug and gene delivery, nanotoxicology of dendritic and inorganic constructs, water-soluble polymers for targeted delivery and poly(amidoamine) dendrimers for oral delivery.
Chitosan-poly is a composite that has been increasingly used to create chitosan-poly(acrylic acid) nanoparticles. More recently, various composite forms have come out with poly(acrylic acid) being synthesized with chitosan which is often used in a variety of drug delivery processes. Chitosan which already features strong biodegradability and biocompatibility nature can be merged with polyacrylic acid to create hybrid nanoparticles that allow for greater adhesion qualities as well as promote the biocompatibility and homeostasis nature of chitosan poly(acrylic acid) complex. The synthesis of this material is essential in various applications and can allow for the creation of nanoparticles to facilitate a variety of dispersal and release behaviors and its ability to encapsulate a multitude of various drugs and particles.
Vitaliy Khutoryanskiy FRSC FAPS is a British and Kazakhstani scientist, a Professor of Formulation Science and a Royal Society Industry Fellow at the University of Reading. His research focuses on polymers, biomaterials, nanomaterials, drug delivery, and pharmaceutical sciences. Khutoryanskiy has published over 200 original research articles, book chapters, and reviews. His publications have attracted > 12000 citations and his current h-index is 54. He received several prestigious awards in recognition for his research in polymers, colloids and drug delivery as well as for contributions to research peer-review and mentoring of early career researchers. He holds several honorary professorship titles from different universities.
Moein Moghimi is a British professor and researcher in the fields of nanomedicine, drug delivery and biomaterials. He is currently the professor of Pharmaceutics and Nanomedicine at the School of Pharmacy and the Translational and Clinical Research Institute at Newcastle University. He is also an adjoint professor at the Skaggs School of Pharmacy, University of Colorado Denver.