Intergenic lcrF RNA thermometer

Last updated
LcrF intergenic thermometer
RF02704.svg
Predicted secondary structure and sequence conservation of LcrF intergenic thermometer
Identifiers
Rfam RF02704
Other data
Domain Bacteria
GO GO:0045975 ,GO:0009266
SO SO:0005836
PDB structures PDBe

RNA thermometers regulate gene expression in response to temperature allowing pathogens like Yersinia to switch on silent genes after entering the host organism. Usually, RNA thermometers are located in the 5'UTR, but an intergenic RNA thermometer was found in Yersinia pseudotuberculosis. The LcrFRNA thermometer together with the thermo-labile YmoA protein activates synthesis of the most crucial virulence activator LcrF (VirF). The RNA thermosensor sequence is 100% identical in all human pathogenic Yersinia species. [1] [2]

References

  1. ↑ Böhme K, Steinmann R, Kortmann J, Seekircher S, Heroven AK, Berger E, Pisano F, Thiermann T, Wolf-Watz H, Narberhaus F, Dersch P (February 2012). "Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence". PLOS Pathogens. 8 (2) e1002518. doi: 10.1371/journal.ppat.1002518 . PMC   3280987 . PMID   22359501.
  2. ↑ Schwiesow L, Lam H, Dersch P, Auerbuch V (December 2015). "Yersinia Type III Secretion System Master Regulator LcrF". Journal of Bacteriology. 198 (4): 604–614. doi:10.1128/JB.00686-15. PMC   4751813 . PMID   26644429.
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