Insulin is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (INS) gene. It is the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats, and protein by promoting the absorption of glucose from the blood into cells of the liver, fat, and skeletal muscles. In these tissues the absorbed glucose is converted into either glycogen, via glycogenesis, or fats (triglycerides), via lipogenesis; in the liver, glucose is converted into both. Glucose production and secretion by the liver are strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is thus an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules in the cells. Low insulin in the blood has the opposite effect, promoting widespread catabolism, especially of reserve body fat.
Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL).
Sir Frederick Grant Banting was a Canadian pharmacologist, orthopedist, and field surgeon. For his co-discovery of insulin and its therapeutic potential, Banting was awarded the Nobel Prize in Physiology or Medicine with John Macleod.
Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urination, fatigue and unexplained weight loss. Symptoms may also include increased hunger, having a sensation of pins and needles, and sores (wounds) that do not heal. Often, symptoms develop slowly. Long-term complications from high blood sugar include heart disease, stroke, diabetic retinopathy, which can result in blindness, kidney failure, and poor blood flow in the lower-limbs, which may lead to amputations. The sudden onset of hyperosmolar hyperglycemic state may occur; however, ketoacidosis is uncommon.
Diabetes Canada is a registered national charity whose mission includes serving the 11 million Canadians living with diabetes or prediabetes. Diabetes Canada programs include:
Sir Kurt George Matthew Mayer Alberti, is a British doctor. His long-standing special interest is diabetes mellitus, in connection with which he has published many research papers and served on many national and international committees. He was President of the European Association for the Study of Diabetes (EASD) and President of the International Diabetes Federation (IDF). In the 1970s, Alberti published recommendations for the management of diabetic ketoacidosis, a serious metabolic emergency which affects people suffering from severe insulin deficiency. This 'Alberti regime' rationalised the use of insulin and fluid therapy in this condition to the undoubted benefit of many patients.
The Banting Memorial Lectures are a yearly series of research presentations given by an expert in diabetes. The name of the lecture series refers to Canadian physician Sir Frederick Banting, who was a seminal scientist, doctor and Nobel laureate for the co-discovery of insulin. The lectures are currently hosted by the American Diabetes Association.
World Diabetes Day (WDD) is the primary global awareness campaign focusing on diabetes mellitus and is held on 14 November each year.
As a medication, insulin is any pharmaceutical preparation of the protein hormone insulin that is used to treat high blood glucose. Such conditions include type 1 diabetes, type 2 diabetes, gestational diabetes, and complications of diabetes such as diabetic ketoacidosis and hyperosmolar hyperglycemic states. Insulin is also used along with glucose to treat hyperkalemia. Typically it is given by injection under the skin, but some forms may also be used by injection into a vein or muscle. There are various types of insulin, suitable for various time spans. The types are often all called insulin in the broad sense, although in a more precise sense, insulin is identical to the naturally occurring molecule whereas insulin analogues have slightly different molecules that allow for modified time of action. It is on the World Health Organization's List of Essential Medicines. In 2021, it was the 179th most commonly prescribed medication in the United States, with more than 2 million prescriptions.
Banting House is a former residence and current museum in London, Ontario, Canada. Located at 442 Adelaide Street North, it is known as the “Birthplace of Insulin.” It is the house where Sir Frederick Banting woke up at two o'clock in the morning on October 31, 1920 with the idea that led to the discovery of insulin.
The St. Vincent Declaration is a set of goals for the health care of people with diabetes mellitus published as the product of an international conference held in St. Vincent, Italy, on 10–12 October 1989.
Researcher - Dr. Dinesh Kacha Research Article - Diabetes Reversal Through Ayurvedic Lifestyle
The condition known today as diabetes is thought to have been described in the Ebers Papyrus. Ayurvedic physicians first noted the sweet taste of diabetic urine, and called the condition madhumeha. The term diabetes traces back to Demetrius of Apamea. For a long time, the condition was described and treated in traditional Chinese medicine asxiāo kě. Physicians of the medieval Islamic world, including Avicenna, have also written on diabetes. Early accounts often referred to diabetes as a disease of the kidneys. In 1674, Thomas Willis suggested that diabetes may be a disease of the blood. Johann Peter Frank is credited with distinguishing diabetes mellitus and diabetes insipidus in 1794.
This article provides a global overview of the current trends and distribution of metabolic syndrome. Metabolic syndrome refers to a cluster of related risk factors for cardiovascular disease that includes abdominal obesity, diabetes, hypertension, and elevated cholesterol.
V. Mohan is an Indian physician/scientist specializing in diabetology. He is the Chairman of Dr. Mohan’s Diabetes Specialities Centre, which is an IDF Centre of Excellence in Diabetes Care. He is also the Chairman of the Madras Diabetes Research Foundation in Chennai which is an ICMR Centre for Advanced Research on Diabetes.
Carl Ronald Kahn is an American physician and scientist, best known for his work with insulin receptors and insulin resistance in diabetes and obesity. He is the Chief Academic Officer at Joslin Diabetes Center, the Mary K. Iacocca Professor of Medicine at Harvard Medical School and a member of the National Academy of Sciences since 1999.
Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. Classic symptoms include thirst, polyuria, weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, including disorders of the cardiovascular system, eye, kidney, and nerves. Diabetes accounts for approximately 4.2 million deaths every year, with an estimated 1.5 million caused by either untreated or poorly treated diabetes.
The Flame of Hope is an eternal flame located in London, Ontario, Canada, that honours Sir Frederick Banting's discovery of insulin, as well as all those who have been affected by diabetes. Simultaneously, it serves as a reminder that insulin manages diabetes but does not cure it; ultimately, it stands for the hope that a cure will soon be found.
Santé Diabète (SD) is a French non-governmental organization (NGOs) whose headquarters is in Grenoble (France) which is working on strengthening health systems to improve the prevention and management of diabetes in Africa. As part of a chronic disease like diabetes, improving the quality of care saves thousands of lives but also improves the quality of life for people living with diabetes.
India has an estimated 100 million people formally diagnosed with diabetes, which makes it the second most affected in the world, after China. Furthermore, 700,000 Indians died of diabetes, hyperglycemia, kidney disease or other complications of diabetes in 2020. One in six people (17%) in the world with diabetes is from India. The number is projected to grow by 2045 to become 134 million per the International Diabetes Federation.
