JUB (gene)

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AJUBA
Identifiers
Aliases AJUBA , JUB, ajuba LIM protein
External IDs OMIM: 609066 MGI: 1341886 HomoloGene: 7789 GeneCards: AJUBA
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198086
NM_001289097
NM_032876

NM_010590

RefSeq (protein)

NP_001276026
NP_116265
NP_932352

NP_034720

Location (UCSC) Chr 14: 22.97 – 22.98 Mb Chr 14: 54.57 – 54.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein ajuba is a protein that in humans is encoded by the JUB gene. [5] [6]

Contents

Function

JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.

Interactions

JUB (gene) has been shown to interact with Stratifin [7] and SLC1A2. [8]

Related Research Articles

Stratifin

Stratifin is a protein encoded by the SFN gene in humans. The protein is named for its presence in stratified epithelial cells.

Excitatory amino acid transporter 2

Excitatory amino acid transporter 2 (EAAT2) also known as solute carrier family 1 member 2 (SLC1A2) and glutamate transporter 1 (GLT-1) is a protein that in humans is encoded by the SLC1A2 gene. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

PEX19

Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.

FUSIP1

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.

ERRFI1

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.

MARK3

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.

MYCBP2

Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the MYCBP2 gene.

RPS6KA4

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.

Plakophilin-3

Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.

M-RIP

Myosin phosphatase Rho-interacting protein is an enzyme that in humans is encoded by the MPRIP gene.

BCLAF1

Bcl-2-associated transcription factor 1 is a Bcl-2 family protein in humans that is encoded by the BCLAF1 gene.

ZNF638

Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene.

SIPA1L1

Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene.

SHCBP1

SHC SH2 domain-binding protein 1 is a protein that in humans is encoded by the SHCBP1 gene.

PEX16

Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.

LMX1A

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.

RHPN2

Rhophilin-2 is a protein that in humans is encoded by the RHPN2 gene.

WDR68

WD repeat-containing protein 68 is a protein that in humans is encoded by the DCAF7 gene.

LIMD1

LIM domain-containing protein 1 is a protein that in humans is encoded by the LIMD1 gene.

SHROOM3

Protein shroom3 also known as shroom-related protein is a protein that in humans is encoded by the SHROOM3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000129474 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022178 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD (Jun 1999). "Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner". Mol Cell Biol. 19 (6): 4379–89. doi:10.1128/MCB.19.6.4379. PMC   104397 . PMID   10330178.
  6. "Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)".
  7. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
  8. Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D (Feb 2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci. 19 (2): 152–64. doi:10.1006/mcne.2001.1066. PMID   11860269.

Further reading