Little split his first professional season between the rookie-level Arizona League Dodgers and Single-A Great Lakes Loons.[3] Little did not play in a game in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic.[4]
Little returned to action in 2021 with the now High-A Great Lakes,posting a 3–1 record and 6.75 ERA with 31 strikeouts in 30+2⁄3 innings pitched across 24 games.[3] He missed the entirety of the 2022 season after undergoing Tommy John surgery.[5][6] Little made 20 relief outings for the Double-A Tulsa Drillers in 2023, but struggled to an 0–1 record and 7.71 ERA with 18 strikeouts across 18+2⁄3 innings pitched.[7] He split the 2024 campaign between Tulsa and Triple-A Oklahoma City, accumulating a combined 3–2 record and 3.79 ERA with 63 strikeouts and five saves across 47 appearances.[8]
Little began the 2025 season with Oklahoma City, posting a 3–2 record and 2.20 ERA with 33 strikeouts and 10 saves over 26 appearances.[3] On June 19, he was selected to the 40-man roster and promoted to the major leagues for the first time.[9] Little made his debut that night against the San Diego Padres, allowing two runs on four hits and a walk in two innings. He also recorded his first career MLB strikeout against Martín Maldonado.[10] He pitched two games for the Dodgers, allowing two runs on four hits in three innings while also pitching to a 4.64 ERA in 36 games for Oklahoma City.[3] Little was designated for assignment by the Dodgers on August 4.[11]
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