While working with Robert G. Edwards at Bourn Hall Clinic, Cambridge, Cohen investigated improving embryo implantation rates.[4] Cohen has been involved in research on the application of micromanipulation techniques to operate on eggs, sperm and embryos. He co-developed partial zone dissection in human oocyte.[5]
In 1982, Cohen joined Bourn Hall Clinic as an embryologist, working with Patrick Steptoe and Robert G. Edwards on techniques to improve human conception through in vitro fertilization (IVF). Robert G. Edwards was the recipient of the Nobel Prize for Medicine and Physiology in 2010. It was in Cambridge that Cohen first successfully froze and thawed a human blastocyst for use in IVF.[9] Cohen also pioneered the use of micromanipulation techniques now widespread among embryologists. He developed a precursor technique of Intracytoplasmic Sperm Injection (ICSI), now used for the treatment of nearly all male factor infertility diagnoses. Assisted Hatching (AH) is another commonly applied technique aimed at increasing implantation rates among infertile couples. Some of his work, such as cytoplasmic transfer, an attempt to boost development using the cytoplasm of donor eggs to supplement eggs from certain infertility patients, and single sperm freezing, has caused considerable ethical debate.[10]
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