On September 13, 2019, the Indians selected Karinchak's contract and promoted him to the major leagues.[8][9] He made his major league debut on September 14 against the Minnesota Twins, pitching 1+1⁄3 scoreless innings and recording three strikeouts.[10]
In 2020, Karinchak pitched in 27 games, compiling a 1–2 record with 2.67 ERA and 53 strikeouts in 27 innings. In his postseason debut, he gave up a grand slam to Gio Urshela then walked two batters before being removed in a loss to the New York Yankees.[11][12]
In 2021, he pitched to a 7–4 record and a 4.07 ERA with 78 strikeouts and 32 walks in 55+1⁄3 innings.[13]
In 2022, with the Cleveland Guardians, Karinchak accumulated a 2–0 record and a 2.08 ERA with 62 strikeouts in 39 innings pitched. Karinchak missed the first few months of the season with shoulder injury, making rehab appearances with the Columbus Clippers before returning to the major leagues on July 4. Karinchak's 2.08 ERA was the 9th lowest among AL relievers. [14] He also pitched in four postseason games, going scoreless in five innings while collecting six strikeouts and issuing four base on balls as Cleveland advanced to the AL Division Series.[15]
Karinchak in 2023
In 2023, Karinchak appeared in 44 games as a relief pitcher for the Guardians, accumulating a 3.23 ERA with 52 strikeouts across 39 innings pitched.[16]
On January 12, 2024, Karinchak agreed to a $1.9 million contract to avoid arbitration,[17] but he also avoided pitching in the majors for the year. Karinchak was placed on the 60–day injured list with right shoulder inflammation before the 2024 season began.[18] He was sent to Columbus for a rehab assignment in September, pitching in seven games but remaining on the injured list for the entirety of the regular season.[19] Karinchak was outrighted off the Guardians' 40–man roster to Triple–A Columbus on November 4. He subsequently rejected the assignment, electing free agency instead.[20]
Chicago White Sox
On January 25, 2025, Karinchak signed a minor league contract with the Chicago White Sox.[21] In 24 appearances for the Triple-A Charlotte Knights, he posted a 3-1 record and 2.45 ERA with 34 strikeouts and two saves across 29+1⁄3 innings pitched. Karinchak was released by the White Sox organization on June 15.[22]
Karinchak faced criticism in 2021 after making a post on Instagram expressing his views on the COVID-19 vaccine mandates. The post included a quote incorrectly attributed to Nazi Party leader Hermann Göring. Karinchak's post was condemned by the Anti-Defamation League of Cleveland.[24][25] In 2022, Karinchak was unable to travel to Toronto for a series against the Blue Jays and placed on the restricted list as he was not vaccinated against COVID-19.[26]
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