Jane Green (geneticist)

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Professor
Jane Green
PhD, OC, ONL, Hon FCCMG, FCAHS
Jane-Green.png
Nationality United Kingdom
Alma materUniversity of British Columbia
Occupation Medical geneticist
EmployerMemorial University of Newfoundland

Professor Jane S. Green PhD, OC ONL , Hon FCCMG, FCAHS (born 1943) is a Canadian medical geneticist.

Contents

Jane S. Green is a well known Canadian medical geneticist who has been in the field for over 40 years, she has contributed and published to many papers, books and presentations with her peers and has been given many awards and recognitions because of it. [1] [2] Her research's in hereditary diseases, concentrating on hereditary cancers and eye disorders. [3] Her extensive research has helped in identifying genetic mutations linked to hereditary cancers, ocular disorders, and syndromic conditions such as Bardet-Biedl syndrome [4] and has shaped the future of medical genetics and Her work has helped the development of clinical and genetic screening programs, [4] which allows for the faster identification and better treatment of hereditary diseases. Dr. green travels across NL to share her work with peers, patients, and families because she believes patient and family care is what's most important above all else. [3]

Career

Dr.Green studied Zoology, obtaining a BSc in 1964, and Drosophila Genetics, obtaining an MSc in 1966, both from the University of British Columbia. [5] She moved to Newfoundland in 1967. [6]

She helped to establish an Ocular Genetics Clinic from 1978 to 1986 and, after a family was referred there with Von Hippel–Lindau disease, began a cancer genetics screening programme. [7]

She became a faculty member at Memorial University of Newfoundland in 1988 and obtained a PhD there in 1995; her dissertation was on the development of clinical and genetic screening programs for hereditary cancer syndromes. [8] She was appointed Professor in the Discipline of Genetics there in 2002, [5] and retired in April 2016. [9]

She is also a Fellow of the Canadian Academy of Health Sciences (FCAHS). [10]

YearPositionsRef
1978 -1988Research Assistant, Faculty of Medicine (Ocular Genetics) [5]
1991 – 1997Assistant Professor, Discipline of Medicine, Faculty of Medicine, Memorial University
1996 – presentConsulting privileges as a Scientist, Non-Medical with the Newfoundland Cancer Treatment and Research Foundation
1996 – presentStaff privileges as Scientist, Non-Medical, Department of Medicine, Eastern Health
1997 – 2000Associate Professor with Tenure, Discipline of Medicine, Faculty of Medicine, Memorial University
1988 – 1991Lecturer, Discipline of Medicine, Faculty of Medicine, Memorial University
2000 – 2002Associate Professor, Discipline of Genetics
2002 – 2016Professor, Discipline of Genetics, Faculty of Medicine, Memorial University
2016 – presentHonorary Research Professor, Discipline of Genetics, Faculty of Medicine, Memorial University

Education

Yearplacecerifcationref
1960 – 1964University of British ColumbiaB.Sc. (Zoology) [5]
1964 – 1965University of British ColumbiaM.Sc. (Genetics)
1980 – 1981University of British Columbia and Vancouver General Hospital(Research Year)
1991 – 1995Memorial UniversityPh.D. (Medical Genetics)

Contributions

Dr.Green as been credited in about 180+ works and some of her most recent ones are publicized in 2024-2025

YearNotable PublicationsRef
1993Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer [11]
1993Genetic Mapping of a Locus Predisposing to Human Colorectal Cancer [12]
1960Report on the algorithmic language ALGOL 60 [13]
2004Comparative Genomics Identifies a Flagellar and Basal Body Proteome that Includes the BBS5 Human Disease Gene [14]
2007Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 [15]
1994Replication Errors in Benign and Malignant Tumors from Hereditary Nonpolyposis Colorectal Cancer Patients [16]
1988Von Hippel–Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma [17]
1989The Cardinal Manifestations of Bardet–Biedl Syndrome, a Form of Laurence–Moon–Biedl Syndrome [18]
2008The Clinical Phenotype of Lynch Syndrome Due to Germ-Line PMS2 Mutations [19]
1995Germline mutations in the von Hippel–Lindau disease tumor suppressor gene: Correlations with phenotype [20]
2007Founder and Recurrent CDH1 Mutations in Families With Hereditary Diffuse Gastric Cancer [21]
1997Germline Mutations of the MEN1 Gene in Familial Multiple Endocrine Neoplasia Type 1 and Related States [22]
1994hMSH2 Mutations in Hereditary Nonpolyposis Colorectal Cancer Kindreds [23]
2016Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care [24]
1994Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype. [25]
2004Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome [26]
2005Clinical and genetic epidemiology of Bardet–Biedl syndrome in Newfoundland: A 22-year prospective, population-based, cohort study [27]
2000Mutations in MKKS cause obesity, retinal dystrophy and renal malformations associated with Bardet-Biedl syndrome [28]
2000Mutations in MKKS cause Bardet-Biedl syndrome [29]
1996Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations. [30]

Awards

List of all awards:
Officer, Order of Canada; Member, Order of Newfoundland and Labrador; Fellow, Canadian Academy of Health Sciences; Honorary Member, Canadian College of Medical Geneticists; Founders Award, Canadian College of Medical Geneticists; CIHR Knowledge Translation Award; Community Service Award, NL Division, Canadian National Institute of the Blind. [5]

References

  1. ↑ "Jane Green, Memorial University of Newfoundland • Expertise Finder Network". network.expertisefinder.com. Retrieved 17 March 2025.
  2. ↑ "Jane S Green". scholar.google.ca. Retrieved 17 March 2025.
  3. 1 2 Rebeiro, Rebecca (6 July 2018). "Highest honour". Gazette - Memorial University of Newfoundland. Retrieved 17 March 2025.
  4. 1 2 "Faculty A-Z | Faculty of Medicine". Memorial University of Newfoundland. Retrieved 27 February 2025.
  5. 1 2 3 4 5 "Faculty A-Z | Faculty of Medicine". Memorial University of Newfoundland. Retrieved 27 February 2025.
  6. ↑ "Dr. Jane Green". Canadians for Health Research. Archived from the original on 31 July 2017. Retrieved 31 July 2017.
  7. ↑ "Clinical Cancer Genetics: Polyposis and Familial Colorectal Cancer c.1975-c.2010 | The History of Modern Biomedicine". histmodbiomed.history.qmul.ac.uk. Retrieved 17 March 2025.
  8. ↑ Green, Jane Stuart (1995). Development, implementation and evaluation of clinical and genetic screening programs for hereditary tumour syndromes (doctoral thesis). Memorial University of Newfoundland.
  9. ↑ "Retirement Celebration for Dr. Jane Green, Discipline of Genetics..." Memorial University of Newfoundland. 11 May 2016. Archived from the original on 31 July 2017. Retrieved 31 July 2017.
  10. ↑ "2013 Recipients - Biographies - 2013 Order of Newfoundland and Labrador". Government of Newfoundland. Archived from the original on 18 July 2017. Retrieved 31 July 2017.
  11. ↑ Leach, Fredrick S.; Nicolaides, Nicholas C.; Papadopoulos, Nickolas; Liu, Bo; Jen, Jin; Parsons, Ramon; Peltomäki, Päivi; Sistonen, Pertti; Aaltonen, Lauri A.; Nyström-Lahti, Minna; Guan, X.-Y.; Zhang, Ji; Meltzer, Paul S.; Yu, Jing-Wei; Kao, Fa-Ten (17 December 1993). "Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer". Cell. 75 (6): 1215–1225. doi: 10.1016/0092-8674(93)90330-S . ISSN   0092-8674. PMID   8261515.
  12. ↑ Peltomäki, Päivi; Aaltonen, Lauri A.; Sistonen, Pertti; Pylkkänen, Lea; Mecklin, Jukka-Pekka; Järvinen, Heikki; Green, Jane S.; Jass, Jeremy R.; Weber, James L.; Leach, Fredrick S.; Petersen, Gloria M.; Hamilton, Stanley R.; de la Chapelle, Albert; Vogelstein, Bert (7 May 1993). "Genetic Mapping of a Locus Predisposing to Human Colorectal Cancer" . Science. 260 (5109): 810–812. Bibcode:1993Sci...260..810P. doi:10.1126/science.8484120. PMID   8484120.
  13. ↑ Backus, J. W.; Bauer, F. L.; Green, J.; Katz, C.; McCarthy, J.; Perlis, A. J.; Rutishauser, H.; Samelson, K.; Vauquois, B.; Wegstein, J. H.; Van Wijngaarden, A.; Woodger, M. (May 1960). Naur, Peter (ed.). "Report on the algorithmic language ALGOL 60". Communications of the ACM. 3 (5): 299–311. doi:10.1145/367236.367262. ISSN   0001-0782.
  14. ↑ Li, Jin Billy; Gerdes, Jantje M.; Haycraft, Courtney J.; Fan, Yanli; Teslovich, Tanya M.; May-Simera, Helen; Li, Haitao; Blacque, Oliver E.; Li, Linya; Leitch, Carmen C.; Lewis, Richard Allan; Green, Jane S.; Parfrey, Patrick S.; Leroux, Michel R.; Davidson, William S. (14 May 2004). "Comparative Genomics Identifies a Flagellar and Basal Body Proteome that Includes the BBS5 Human Disease Gene". Cell. 117 (4): 541–552. doi:10.1016/S0092-8674(04)00450-7. ISSN   0092-8674. PMID   15137946.
  15. ↑ Zanke, Brent W.; Greenwood, Celia MT; Rangrej, Jagadish; Kustra, Rafal; Tenesa, Albert; Farrington, Susan M.; Prendergast, James; Olschwang, Sylviane; Chiang, Theodore; Crowdy, Edgar; Ferretti, Vincent; Laflamme, Philippe; Sundararajan, Saravanan; Roumy, Stéphanie; Olivier, Jean-François (August 2007). "Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24" . Nature Genetics. 39 (8): 989–994. doi:10.1038/ng2089. ISSN   1546-1718. PMID   17618283.
  16. ↑ Aaltonen, Lauri A.; Peltomäki, Päivi; Mecklin, Jukka-Pekka; Järvinen, Heikki; Jass, Jeremy R.; Green, Jane S.; Lynch, Henry T.; Watson, Patrice; Tallqvist, Gustav; Juhola, Matti; Sistonen, Pertti; Hamilton, Stanley R.; Kinzler, Kenneth W.; Vogelstein, Bert; de la Chapelle, Albert (1 April 1994). "Replication Errors in Benign and Malignant Tumors from Hereditary Nonpolyposis Colorectal Cancer Patients1". Cancer Research. 54 (7): 1645–1648. ISSN   0008-5472.
  17. ↑ Seizinger, B. R.; Rouleau, G. A.; Ozelius, L. J.; Lane, A. H.; Farmer, G. E.; Lamiell, J. M.; Haines, J.; Yuen, J. W. M.; Collins, D.; Majoor-Krakauer, D.; Bonner, T.; Mathew, C.; Rubenstein, A.; Halperin, J.; McConkie-Rosell, A. (March 1988). "Von Hippel–Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma" . Nature. 332 (6161): 268–269. Bibcode:1988Natur.332..268S. doi:10.1038/332268a0. ISSN   1476-4687. PMID   2894613.
  18. ↑ Green, Jane S.; Parfrey, Patrick S.; Harnett, John D.; Farid, Nadir R.; Cramer, Benvon C.; Johnson, Gordon; Heath, Olga; McManamon, Patrick J.; O'Leary, Elizabeth; Pryse-Phillips, William (12 October 1989). "The Cardinal Manifestations of Bardet–Biedl Syndrome, a Form of Laurence–Moon–Biedl Syndrome" . New England Journal of Medicine. 321 (15): 1002–1009. doi:10.1056/NEJM198910123211503. ISSN   0028-4793. PMID   2779627.
  19. ↑ Senter, Leigha; Clendenning, Mark; Sotamaa, Kaisa; Hampel, Heather; Green, Jane; Potter, John D.; Lindblom, Annika; Lagerstedt, Kristina; Thibodeau, Stephen N.; Lindor, Noralane M.; Young, Joanne; Winship, Ingrid; Dowty, James G.; White, Darren M.; Hopper, John L. (1 August 2008). "The Clinical Phenotype of Lynch Syndrome Due to Germ-Line PMS2 Mutations". Gastroenterology. 135 (2): 419–428.e1. doi:10.1053/j.gastro.2008.04.026. ISSN   0016-5085. PMC   2759321 . PMID   18602922.
  20. ↑ Chen, Fan; Kishida, Takeshi; Yao, Masahiro; Hustad, Thomas; Glavac, Damjan; Dean, Michael; Gnarra, James R.; Orcutt, Mary Lou; Duh, Fuh Mei; Glenn, Gladys; Green, Jane; Hsia, Y. Edward; Lamiell, James; Li, Hua; Wei, Ming Hui (1995). "Germline mutations in the von Hippel–Lindau disease tumor suppressor gene: Correlations with phenotype". Human Mutation. 5 (1): 66–75. doi: 10.1002/humu.1380050109 . ISSN   1098-1004. PMID   7728151.
  21. ↑ Kaurah, Pardeep; MacMillan, Andrée; Boyd, Niki; Senz, Janine; De Luca, Alessandro; Chun, Nicki; Suriano, Gianpaolo; Zaor, Sonya; Van Manen, Lori; Gilpin, Cathy; Nikkel, Sarah; Connolly-Wilson, Mary; Weissman, Scott; Rubinstein, Wendy S.; Sebold, Courtney (6 June 2007). "Founder and Recurrent CDH1 Mutations in Families With Hereditary Diffuse Gastric Cancer" . JAMA. 297 (21): 2360–2372. doi:10.1001/jama.297.21.2360. ISSN   0098-7484. PMID   17545690.
  22. ↑ Agarwal, Sunita K.; Beth Kester, Mary; Debelenko, Larisa V.; Heppner, Christina; Emmert-Buck, Michael R.; Skarulis, Monica C.; Doppman, John L.; Kim, Young S.; Lubensky, Irina A.; Zhuang, Zhengping; Green, Jane S.; Guru, Sirandanahalli C.; Manickam, Pachiappan; Olufemi, Shodimu-Emmanuel; Liotta, Lance A. (1 July 1997). "Germline Mutations of the MEN1 Gene in Familial Multiple Endocrine Neoplasia Type 1 and Related States". Human Molecular Genetics. 6 (7): 1169–1175. doi:10.1093/hmg/6.7.1169. ISSN   0964-6906. PMID   9215689.
  23. ↑ Liu, Bo; Parsons, Ramon E.; Hamilton, Stanley R.; Petersen, Gloria M.; Lynch, Henry T.; Watson, Patrice; Markowitz, Sanford; Willson, James K.V.; Green, Jane; de la Chapelle, Albert; Kinzler, Kenneth W.; Vogelstein, Bert (1 September 1994). "hMSH2 Mutations in Hereditary Nonpolyposis Colorectal Cancer Kindreds1". Cancer Research. 54 (17): 4590–4594. ISSN   0008-5472. PMID   8062247.
  24. ↑ Sawyer, S.l.; Hartley, T.; Dyment, D.a.; Beaulieu, C.l.; Schwartzentruber, J.; Smith, A.; Bedford, H.m.; Bernard, G.; Bernier, F.p.; Brais, B.; Bulman, D.e.; Warman Chardon, J.; Chitayat, D.; Deladoëy, J.; Fernandez, B.a. (2016). "Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care". Clinical Genetics. 89 (3): 275–284. doi:10.1111/cge.12654. ISSN   1399-0004. PMC   5053223 . PMID   26283276.
  25. ↑ Crossey, P A; Richards, F M; Foster, K; Green, J S; Prowse, A; Latif, F; Lerman, M I; Zbar, B; Affara, N A; Ferguson-Smith, M A (1 August 1994). "Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype" . Human Molecular Genetics. 3 (8): 1303–1308. doi:10.1093/hmg/3.8.1303. ISSN   1460-2083. PMID   7987306.
  26. ↑ Fan, Yanli; Esmail, Muneer A.; Ansley, Stephen J.; Blacque, Oliver E.; Boroevich, Keith; Ross, Alison J.; Moore, Susan J.; Badano, Jose L.; May-Simera, Helen; Compton, Deanna S.; Green, Jane S.; Lewis, Richard Alan; van Haelst, Mieke M.; Parfrey, Patrick S.; Baillie, David L. (September 2004). "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome" . Nature Genetics. 36 (9): 989–993. doi:10.1038/ng1414. ISSN   1546-1718. PMID   15314642.
  27. ↑ Moore, Susan J.; Green, Jane S.; Fan, Yanli; Bhogal, Ashvinder K.; Dicks, Elizabeth; Fernandez, Bridget A.; Stefanelli, Mark; Murphy, Christopher; Cramer, Benvon C.; Dean, John C.S.; Beales, Philip L.; Katsanis, Nicholas; Bassett, Anne S.; Davidson, William S.; Parfrey, Patrick S. (2005). "Clinical and genetic epidemiology of Bardet–Biedl syndrome in Newfoundland: A 22-year prospective, population-based, cohort study". American Journal of Medical Genetics Part A. 132A (4): 352–360. doi:10.1002/ajmg.a.30406. ISSN   1552-4833. PMC   3295827 . PMID   15637713.
  28. ↑ Katsanis, Nicholas; Beales, Philip L.; Woods, Michael O.; Lewis, Richard A.; Green, Jane S.; Parfrey, Patrick S.; Ansley, Stephen J.; Davidson, William S.; Lupski, James R. (September 2000). "Mutations in MKKS cause obesity, retinal dystrophy and renal malformations associated with Bardet-Biedl syndrome" . Nature Genetics. 26 (1): 67–70. doi:10.1038/79201. ISSN   1546-1718. PMID   10973251.
  29. ↑ Slavotinek, Anne M.; Stone, Edwin M.; Mykytyn, Kirk; Heckenlively, John R.; Green, Jane S.; Heon, Elise; Musarella, Maria A.; Parfrey, Patrick S.; Sheffield, Val C.; Biesecker, Leslie G. (September 2000). "Mutations in MKKS cause Bardet-Biedl syndrome" . Nature Genetics. 26 (1): 15–16. doi:10.1038/79116. ISSN   1546-1718. PMID   10973238.
  30. ↑ Maher, E R; Webster, A R; Richards, F M; Green, J S; Crossey, P A; Payne, S J; Moore, A T (1 April 1996). "Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations". Journal of Medical Genetics. 33 (4): 328–332. doi:10.1136/jmg.33.4.328. ISSN   1468-6244. PMC   1050584 . PMID   8730290.
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