The pancreas is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine gland, i.e. it has both an endocrine and a digestive exocrine function. 99% of the pancreas is exocrine and 1% is endocrine. As an endocrine gland, it functions mostly to regulate blood sugar levels, secreting the hormones insulin, glucagon, somatostatin, and pancreatic polypeptide. As a part of the digestive system, it functions as an exocrine gland secreting pancreatic juice into the duodenum through the pancreatic duct. This juice contains bicarbonate, which neutralizes acid entering the duodenum from the stomach; and digestive enzymes, which break down carbohydrates, proteins, and fats in food entering the duodenum from the stomach.
Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass. These cancerous cells have the ability to invade other parts of the body. A number of types of pancreatic cancer are known.
Mina J. Bissell is an Iranian-American biologist known for her research on breast cancer. In particular, she has studied the effects of a cell's microenvironment, including its extracellular matrix, on tissue function.
The International Cancer Genome Consortium (ICGC) is a voluntary scientific organization that provides a forum for collaboration among the world's leading cancer and genomic researchers. The ICGC was launched in 2008 to coordinate large-scale cancer genome studies in tumours from 50 cancer types and/or subtypes that are of main importance across the globe.
Oncolytics Biotech Inc. is a Canadian company headquartered in Calgary, Alberta, that is developing an intravenously delivered immuno-oncolytic virus called pelareorep for the treatment of solid tumors and hematological malignancies. Pelareorep is a non-pathogenic, proprietary isolate of the unmodified reovirus that: induces selective tumor lysis and promotes an inflamed tumor phenotype through innate and adaptive immune responses.
Ductal cells refer to the epithelial cell lining of the pancreatic duct that deliver enzymes from the acinar cells to the duodenum. They have the essential function of producing bicarbonate-rich (HCO3-) secretion to neutralize stomach acidity. The hormone secretin stimulates ductal cells and is responsible for maintaining the duodenal pH and preventing duodenal injury from acidic chyme. Ductal cells mix their production with acinar cells to make up the pancreatic juice.
Demcizumab is a humanized monoclonal antibody which is used to treat patients with pancreatic cancer or non-small cell lung cancer. Demcizumab has completed phase 1 trials and is currently undergoing phase 2 trials. Demcizumab was developed by OncoMed Pharmaceuticals in collaboration with Celgene.
Mary Katharine Levinge Collins, Lady Hunt is a British Professor of Immunology. She served as Provost at the Okinawa Institute of Science and Technology in Japan. Formerly, Collins taught in the Division of Infection and Immunity at University College London, and was the head of the Division of Advanced Therapies at the National Institute for Biological Standards and Control, and the Director of the Medical Research Council Centre for Medical Molecular Virology. Her research group studies the use of viruses as vectors for introducing new genes into cells, which can be useful for experimental cell biology, for clinical applications such as gene therapy, and as cancer vaccines.
David Arthur Tuveson is an American cancer biologist and is currently Roy J. Zuckerberg Professor of Cancer Research as well as The Cancer Center Director at Cold Spring Harbor Laboratory. Dr. Tuveson is also the Chief Scientist for the Lustgarten Foundation for Pancreatic Cancer Research. He is known for developing some of the first mouse models of pancreatic cancer and more recently, for his work developing pancreatic cancer organoids.
Norman Post Salzman was an American virologist. He spent much of his career as a scientist at the United States National Institutes of Health, where he rose to become the chief of the Laboratory on the Biology of Viruses; after retiring from the NIH in 1986, he worked at Georgetown University and later at the Frederick Cancer Research and Development Center. Salzman died of pancreatic cancer in 1997 at age 71.
Anna Marie (Ann) Skalka is an American virologist, molecular biologist and geneticist who is professor emeritus and senior advisor to the president at the Fox Chase Cancer Center. She is a co-author of a textbook on virology, Principles of Virology.
Tannishtha Reya is an Indian-born American cell and developmental biologist working in cancer research at the University of California San Diego. She has received numerous awards, including an NIH Director's Pioneer Award in 2009 and an NCI Outstanding Investigator Award in 2015. Reya is particularly known for co-authoring an influential publication in 2001 coining the term "cancer stem cell" to describe a cancer cell that mirrors the properties of stem cells of healthy organs in the context of leukaemias or solid tumours.
Patricia Gail Spear is an American virologist. She is a professor emeritus of microbiology and immunology at Northwestern University in Evanston, Illinois. She is best known for her pioneering work studying the herpes simplex virus. Spear is a past president of the American Society for Virology and an elected member of the National Academy of Sciences.
Jose Russo is a senior member and professor at Fox Chase Cancer Center, director of both the Irma H Russo, MD- Breast Cancer Research Laboratory and the Environment Research Center at FCCC-Temple Health. He is also a professor of biochemistry at the Temple Medical School in Philadelphia and an adjunct professor in pathology and cell biology at Thomas Jefferson College of Medicine.
Dannielle Engle is an American biologist and assistant professor of the regulatory biology laboratory at the Salk Institute for Biological Studies. Engle’s research aims at improving detection and treatment of pancreatic cancer.
Priyabrata Mukherjee is an American, academic researcher and professor. He is a Presbyterian Health Foundation presidential professor at the University of Oklahoma Health Sciences Center and associate director for translational research at Stephenson Cancer Center at the OU Health Sciences Center. He also holds the Peggy and Charles Stephenson endowed chair in cancer laboratory research at the OU Health Sciences Center.
Axel Behrens is a German-British molecular biologist and an expert in cancer stem cell biology. He is the Scientific Director of the Cancer Research UK Convergence Science Centre in London, a senior group leader at the Institute of Cancer Research and a professor at Imperial College London.
Lisa M. Coussens is an American cancer scientist who is Chair of the Department of Cell, Developmental and Cancer Biology and Professor and Associate Director for Basic Research in the Knight Cancer Institute at the Oregon Health & Science University. She serves as President of the American Association for Cancer Research.
Michelle Adair Ozbun is an American molecular virologist who is the Maralyn S. Budke Endowed Professor in Viral Oncology at the University of New Mexico School of Medicine. Her research considers cancer biology and how human papillomavirus infections cause pathology including their contributions to cancers.
Edna "Eti" Cukierman is a Mexican biochemist who is a professor at the Fox Chase Cancer Center. She serves as co-director of the Marvin & Concetta Greenberg Pancreatic Cancer Institute. Her research investigates pancreatic cancer and the tumor microenvironment.
