Jelleine

Jelleine is a family of peptides, isolated from the royal jelly of Apis mellifera iberiensis, a subspecies of the honey bee. This new family has the potential to be used in the development of new drugs. ^[1]

Discovery

Jelleines were first isolated in 2004 by the research group of Professor Mario Sergio Palma at São Paulo State University, Brazil. First, he collected royal jelly from a group of honey bee larvae and purified the results by reverse phase, high-performance liquid chromatography. This purified royal jelly showed antimicrobial activity against different bacteria. ^[2] So far, four peptides have been found in this family, each one containing the carboxamide C-terminal.

Medical research

Jelleine exhibits antimicrobial activity against S. epidermidis . ^[3]

References

1. Lima, William Gustavo; Brito, Julio Cesar Moreira; Verly, Rodrigo Moreira; Lima, Maria Elena de (January 26, 2024). "Jelleine, a Family of Peptides Isolated from the Royal Jelly of the Honey Bees (Apis mellifera), as a Promising Prototype for New Medicines: A Narrative Review". Toxins. 16 (1): 24. doi: 10.3390/toxins16010024 . PMC   10819630 . PMID   38251241.
2. Fontana, Renato; Mendes, Maria Anita; de Souza, Bibiana Monson; Konno, Katsuhiro; César, Lílian Mari Marcondes; Malaspina, Osmar; Palma, Mario Sergio (June 26, 2004). "Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera)". Peptides. 25 (6): 919–928. doi:10.1016/j.peptides.2004.03.016. PMID   15203237. S2CID   6839870.
3. Agarwal S, Sharma G, Dang S, Gupta S, Gabrani R (2016). "Antimicrobial Peptides as Anti-Infectives against Staphylococcus epidermidis". Med Princ Pract. 25 (4): 301–8. doi:10.1159/000443479. PMC   5588407 . PMID   26684017.