Jennifer Pietenpol

Last updated
Jennifer Pietenpol
Born (1964-07-18) July 18, 1964 (age 60)
EducationBS, Biology, 1986, Carleton College

PhD, 1990, Vanderbilt University

Postdoc, Johns Hopkins University
Known for p53, p73, Breast Cancer, Triple Negative Breast Cancer, VICC
Scientific career
Institutions Johns Hopkins University Vanderbilt University

Jennifer Pietenpol (born 1964) is Chief Scientific and Strategic Officer, Executive Vice-President for Research, and the Ingram Professor of Cancer Research at Vanderbilt University Medical Center. [1] Pietenpol additionally serves as the Chief Scientific Advisor to the Susan G. Komen Foundation for breast cancer. [2]

Contents

Pietenpol's early research focused on the signaling of the p53 gene within the breast cancer family, specifically Triple Negative Breast Cancer. [3] [4] [5] Pietenpol used a combined approach of bioinformatics and genetics to make discoveries on the signaling behavior of the p53 gene family. [6] [7]

Pietenpol serves as an elected fellow of the American Association for the Advancement of Science (2012) and the American Association for Cancer Research Academy (2022). [3] In 2008 she was appointed by President George Bush to serve on the National Cancer Advisory Board for the National Cancer Institute. [8] In 2016 she was selected to serve on then Vice-President Joe Biden's National Cancer Moonshot Program's Blue Ribbon Panel. [9] [10]

Education

Pietenpol studied biology at Carleton College in Northfield, Minnesota, where she now serves on the board of trustees. [11] She was a student athlete and still holds some of Carleton's volleyball and track and field team records. [12] [13] She received her PhD in cell biology at Vanderbilt University School of Medicine in 1990. [14] She later did postgraduate studies at Johns Hopkins School of Medicine. She was an assistant professor of Biochemistry at Vanderbilt from 1994. [15]

Research

Pietenpol and her research group have developed techniques for analysis of p53 and p53 family member chromatin binding and identification of p53 family target genes. [16] [17] [18] Her team is also responsible for delineating p73 binding sites within the mammal the genome and the discovery that p73, another mammal protein gene, is required for ovarian folliculogenesis, multiciliogenesis, and certain regulation of the Foxj1-associated genes within mammals. [19] [20]

Her team successfully classified TNBC into 4 molecular subtypes―basal-like 1 (BL1), basal-like 2 (BL2), mesenchymal (M), and luminal androgen receptor (LAR). This was performed by the integration of molecular genomic techniques with bioinformatics, a tenant of Pietenpol's work. [21] [22] [23]

Recently, she and her team has focused on better understanding LAR TNBC, which is a rare subtype of TNBC that expresses androgen receptors, making it difficult to clinically treat. [24] [25]

Citations

Pietenpol has published over 250 scientific papers, which have been cited nearly 20,000 times, in journals including Nature , Cell , Cancer Research , and The Journal of Clinical Investigation . [26] [27]

Awards and Affiliations

References

  1. ↑ "Jennifer A. Pietenpol, Ph.D. | Pietenpol & Lehmann Lab". www.vumc.org.
  2. ↑ "Our Scientific Advisory Board".
  3. 1 2 "Jennifer A. Pietenpol, Ph.D. | Pietenpol & Lehmann Lab". www.vumc.org. Retrieved 2025-02-06.
  4. ↑ Lehmann, Brian D.; Bauer, Joshua A.; Chen, Xi; Sanders, Melinda E.; Chakravarthy, A. Bapsi; Shyr, Yu; Pietenpol, Jennifer A. (2011-07-01). "Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies". The Journal of Clinical Investigation. 121 (7): 2750–2767. doi:10.1172/JCI45014. ISSN   0021-9738. PMC   3127435 . PMID   21633166.
  5. ↑ Center, Vanderbilt University Medical. "Vulnerability found in immunotherapy-resistant triple-negative breast cancer". medicalxpress.com. Retrieved 2025-02-06.
  6. ↑ "Dr. Jennifer A. Pietenpol Honored With the 2024 Science of Oncology Award for Groundbreaking Discoveries in Triple-Negative Breast Cancer". dailynews.ascopubs.org. Retrieved 2025-02-06.
  7. ↑ "Jennifer A. Pietenpol, PhD". American Association for Cancer Research (AACR). Retrieved 2025-02-06.
  8. ↑ Communications, VUMC News and (2008-06-16). "President names Jennifer Pietenpol to National Cancer Advisory Board". VUMC News. Retrieved 2025-02-06.
  9. ↑ "Blue Ribbon Panel Announced to Help Guide Vice President Biden's National Cancer Moonshot Initiative". National Institutes of Health (NIH). 2016-04-04. Retrieved 2025-02-06.
  10. ↑ "Shop Talk". Oncology Times. 38 (9): 41. 2016-05-10. doi:10.1097/01.COT.0000483236.45673.de. ISSN   0276-2234.
  11. ↑ Trustees, Board of. "Board of Trustees - Carleton College". www.carleton.edu. Retrieved 2025-02-06.
  12. ↑ "CARLETON VOLLEYBALL RECORD BOOK" (PDF). 2016. Retrieved 2025-02-06.
  13. ↑ "Carleton College Women's Track and Field Honor Roll" (PDF). 2025-02-07.
  14. ↑ "Jennifer A. Pietenpol, Ph.D. | Pietenpol & Lehmann Lab". www.vumc.org. Retrieved 2025-02-06.
  15. ↑ "Pietenpol named Cancer Center director". VUMC News. Retrieved 2025-02-06.
  16. ↑ Rosenbluth, Jennifer M.; Mays, Deborah J.; Jiang, Aixiang; Shyr, Yu; Pietenpol, Jennifer A. (2011-02-01). "Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis". Proceedings of the National Academy of Sciences. 108 (5): 2076–2081. Bibcode:2011PNAS..108.2076R. doi: 10.1073/pnas.1011936108 . PMC   3033306 . PMID   21245298.
  17. ↑ Rosenbluth, Jennifer M.; Mays, Deborah J.; Pino, Maria F.; Tang, Luo Jia; Pietenpol, Jennifer A. (2008-10-01). "A Gene Signature-Based Approach Identifies mTOR as a Regulator of p73". Molecular and Cellular Biology. 28 (19): 5951–5964. doi:10.1128/MCB.00305-08. PMC   2547001 . PMID   18678646.
  18. ↑ Perez, C. A.; Ott, J.; Mays, D. J.; Pietenpol, J. A. (2007-11-01). "p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm". Oncogene. 26 (52): 7363–7370. doi:10.1038/sj.onc.1210561. ISSN   1476-5594. PMID   17563751.
  19. ↑ Marshall, Clayton B.; Mays, Deborah J.; Beeler, J. Scott; Rosenbluth, Jennifer M.; Boyd, Kelli L.; Santos-Guasch, Gabriela L.; Shaver, Timothy M.; Tang, Lucy J.; Liu, Qi; Shyr, Yu; Venters, Bryan J.; Magnuson, Mark A.; Pietenpol, Jennifer A. (2016-03-15). "p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network". Cell Reports. 14 (10): 2289–2300. doi:10.1016/j.celrep.2016.02.035. ISSN   2211-1247. PMC   4794398 . PMID   26947080.
  20. ↑ Guasch, Gabriela L. Santos; Beeler, J. Scott; Marshall, Clayton B.; Shaver, Timothy M.; Sheng, Quanhu; Johnson, Kimberly N.; Boyd, Kelli L.; Venters, Bryan J.; Cook, Rebecca S.; Pietenpol, Jennifer A. (2018-10-26). "p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion". iScience. 8: 236–249. Bibcode:2018iSci....8..236S. doi:10.1016/j.isci.2018.09.018. ISSN   2589-0042. PMC   6197761 . PMID   30340069.
  21. ↑ Lehmann, Brian D.; Bauer, Joshua A.; Chen, Xi; Sanders, Melinda E.; Chakravarthy, A. Bapsi; Shyr, Yu; Pietenpol, Jennifer A. (2011-07-01). "Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies". The Journal of Clinical Investigation. 121 (7): 2750–2767. doi:10.1172/JCI45014. ISSN   0021-9738. PMC   3127435 . PMID   21633166.
  22. ↑ Chen, Xi; Li, Jiang; Gray, William H.; Lehmann, Brian D.; Bauer, Joshua A.; Shyr, Yu; Pietenpol, Jennifer A. (2012-01-01). "TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer". Cancer Informatics. 11: 147–156. doi:10.4137/CIN.S9983. ISSN   1176-9351. PMC   3412597 . PMID   22872785.
  23. ↑ Lehmann, Brian D.; Jovanović, Bojana; Chen, Xi; Estrada, Monica V.; Johnson, Kimberly N.; Shyr, Yu; Moses, Harold L.; Sanders, Melinda E.; Pietenpol, Jennifer A. (2016-06-16). "Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection". PLOS ONE. 11 (6): e0157368. Bibcode:2016PLoSO..1157368L. doi: 10.1371/journal.pone.0157368 . ISSN   1932-6203. PMC   4911051 . PMID   27310713.
  24. ↑ Lehmann, Brian D.; Bauer, Joshua A.; Schafer, Johanna M.; Pendleton, Christopher S.; Tang, Luojia; Johnson, Kimberly C.; Chen, Xi; Balko, Justin M.; Gómez, Henry; Arteaga, Carlos L.; Mills, Gordon B.; Sanders, Melinda E.; Pietenpol, Jennifer A. (2014-08-08). "PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors". Breast Cancer Research. 16 (4): 406. doi: 10.1186/s13058-014-0406-x . ISSN   1465-542X. PMC   4187324 . PMID   25103565.
  25. ↑ Lehmann, Brian D.; Abramson, Vandana G.; Sanders, Melinda E.; Mayer, Erica L.; Haddad, Tufia C.; Nanda, Rita; Van Poznak, Catherine; Storniolo, Anna Maria; Nangia, Julie R.; Gonzalez-Ericsson, Paula I.; Sanchez, Violeta; Johnson, Kimberly N.; Abramson, Richard G.; Chen, Sheau-Chiann; Shyr, Yu (2020-05-01). "TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR+ Metastatic Triple-Negative Breast Cancer". Clinical Cancer Research. 26 (9): 2111–2123. doi:10.1158/1078-0432.CCR-19-2170. ISSN   1078-0432. PMC   7196503 . PMID   31822498.
  26. ↑ "Jennifer Pietenpol". scholar.google.com. Retrieved 2025-02-06.
  27. ↑ Pietenpol, Jennifer A.; Vogelstein, Bert (1993-09-01). "No room at the p53 inn". Nature. 365 (6441): 17–18. Bibcode:1993Natur.365...17P. doi:10.1038/365017a0. ISSN   1476-4687. PMID   8361531.
  28. ↑ "Investigators in the Pathogenesis of Infectious Disease". Burroughs Wellcome Fund. Retrieved 2025-02-06.
  29. ↑ "Faculty and Graduate Student Awards". College of Arts and Science. Retrieved 2025-02-06.
  30. ↑ "The Johns Hopkins University - Society of Scholars". pages.jh.edu. Retrieved 2025-02-06.
  31. ↑ "Faculty Affairs" . Retrieved 2025-02-06.
  32. ↑ "Carleton 1986 Distinguished Alumni (Reunion)" (PDF). apps.carleton.edu. Archived from the original (PDF) on 2013-12-26. Retrieved 2025-02-06.
  33. ↑ "Jennifer Pietenpol receives award from T.J. Martell Foundation". The Cancer Letter. 2016-03-25. Retrieved 2025-02-06.
  34. ↑ "Faculty Awards and Distinctions". Vanderbilt University. Retrieved 2025-02-06.
  35. ↑ "Dr. Jennifer A. Pietenpol Honored With the 2024 Science of Oncology Award for Groundbreaking Discoveries in Triple-Negative Breast Cancer". dailynews.ascopubs.org.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.