John Oghalai (born December 14, 1968)[citation needed] is an American physician and scientist. He is the Leon J. Tiber and David S. Alpert Chair in Medicine at the University of Southern California Keck School of Medicine and chair of the USC Caruso Department of Otolaryngology.[1][2] Oghalai is an otolaryngologist.[3] His research focuses on anatomical[4] and molecular mechanisms in hearing and in ear and hearing disorders.[5][6]
In 2003, Oghalai joined the faculty at the Baylor College of Medicine as an assistant professor.[12][13] He served as director at The Hearing Center at Texas Children's Hospital in Houston, TX in 2005.[14] He became an associate professor at Baylor in 2009.[15][13]
In 2010, Oghalai moved to Stanford University School of Medicine as an associate professor and became a full professor in 2015.[6][13] He became professor of otolaryngology and director of the Children's Hearing Center at Stanford's Lucile Packard Children's Hospital in 2016.[4]
In a 2000 study, Oghalai and colleagues examined incidence of benign paroxysmal positional vertigo (BPPV) in geriatric patients at a Houston hospital. They found that 9% of the sample population had undiagnosed BPPV,[3] a predictor of fall risk, depression, and difficulties with daily activities.[22][23]
To help understand mechanisms of hearing loss brought on by explosive pressures such as those soldiers experience when exposed to roadside bombs, in 2013 Oghalai and his team studied blast effects on hearing in mice. They found that the main traumatic damage leading to noise-induced hearing loss was to cochlear hair and nerve cells,[24] the cells responsible for translating pressure waves into the nerve signals in hearing.[6][25]
In 2018, Oghalai and colleagues studied molecular dimensions of noise-induced hearing loss in mice by using optical coherence tomography, an imaging technique that allows in vivo (instead of invasive) observation and measurement. They found that after blasts damage hair cells, there is also a build up of ionized potassium in cochlear fluid.[5] The findings showed how high concentrations of potassium disrupts hair and nerve cells, whose degeneration or synaptopathy contributes to hearing loss.[26][27][28]
In 2022 Oghalai and colleagues published results for a longitudinal study on the effects of cochlear implants on deaf children with developmental delays. They compared cohorts of children who received the implants to a cohort of children who, due to insurance protocols, were only given hearing aids. The children who received implants showed improved cognitive and behavioral functioning.[29][30][31]
Personal life
John Oghalai is married to Tracy Nguyen-Oghalai, a rheumatologist. They have two sons, Kevin[32] and Tom.[2]
Selected publications
Oghalai, JS; Manolidis, S; Barth, JL; Stewart, MG; Jenkins, HA (2000). "Unrecognized Benign Paroxysmal Positional Vertigo in Elderly Patients". Otolaryngology–Head and Neck Surgery. 122 (5): 630–634. doi:10.1016/S0194-5998(00)70187-2. PMID10793337. S2CID33401924.
↑ Irvine, Martha (23 September 2005). "What's that?; Experts say increased headphone use exacerbates hearing loss in youth". The Record (Kitchener, Ont.).
↑ McMurphy AB, Oghalai JS (2005). "Repair of iatrogenic temporal lobe encephalocele after canal wall down mastoidectomy in the presence of active cholesteatoma". Otol Neurotol. 26 (4): 587–94. doi:10.1097/01.mao.0000178119.46290.e1. PMID16015151. S2CID37589021.
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