Jonathan Gershenzon | |
|---|---|
 Gershenzon in 2015 | |
| Born | 1955 |
| Nationality | American |
| Education | |
| Spouse | Kimberly Falk |
| Children | Two daughters |
| Awards | German National Academy of Sciences Leopoldina |
| Scientific career | |
| Fields | Biochemistry of secondary plant metabolites |
| Institutions | |
Jonathan Gershenzon (born 1955) is an American biochemist.
After studying biology as an undergraduate at the University of California in Santa Cruz, Gershenzon received his PhD in botany from the University of Texas in 1984. From 1985 until 1997 he worked as a scientist at the Institute for Biological Chemistry, Washington State University in Pullman. Since 1997 he is a Director and Scientific Member at the Max Planck Institute for Chemical Ecology in Jena, Germany, where he heads the Department of Biochemistry. [1] He was appointed Honorary Professor at Friedrich Schiller University Jena in 1999. He is married to Kimberly Falk and is the father of Camille and Julia Gershenzon.
Gershenzon studies the biochemistry of secondary plant metabolites, their mode of action on herbivores, the regulation of secondary metabolisms in plants and the evolution of pathways. [2] Most of the work in his department focuses on two major groups of plant defenses: glucosinolates and terpenoids.
A herbivore is an animal anatomically and physiologically adapted to eating plant material, for example foliage or marine algae, for the main component of its diet. As a result of their plant diet, herbivorous animals typically have mouthparts adapted to rasping or grinding. Horses and other herbivores have wide flat teeth that are adapted to grinding grass, tree bark, and other tough plant material.
Erysimum, or wallflower, is a genus of flowering plants in the cabbage family, Brassicaceae. It includes more than 150 species, both popular garden plants and many wild forms. The genus Cheiranthus is sometimes included here in whole or in part. Erysimum has since the early 21st century been ascribed to a monogeneric cruciferous tribe, Erysimeae, characterised by sessile, stellate (star-shaped) and/or malpighiaceous (two-sided) trichomes, yellow to orange flowers and multiseeded siliques.
The terpenoids, also known as isoprenoids, are a class of naturally occurring organic chemicals derived from the 5-carbon compound isoprene and its derivatives called terpenes, diterpenes, etc. While sometimes used interchangeably with "terpenes", terpenoids contain additional functional groups, usually containing oxygen. When combined with the hydrocarbon terpenes, terpenoids comprise about 80,000 compounds. They are the largest class of plant secondary metabolites, representing about 60% of known natural products. Many terpenoids have substantial pharmacological bioactivity and are therefore of interest to medicinal chemists.
Chemical ecology is the study of chemically-mediated interactions between living organisms, and the effects of those interactions on the demography, behavior and ultimately evolution of the organisms involved. It is thus a vast and highly interdisciplinary field. Chemical ecologists seek to identify the specific molecules that function as signals mediating community or ecosystem processes and to understand the evolution of these signals. The substances that serve in such roles are typically small, readily-diffusible organic molecules, but can also include larger molecules and small peptides.
Glucosinolates are natural components of many pungent plants such as mustard, cabbage, and horseradish. The pungency of those plants is due to mustard oils produced from glucosinolates when the plant material is chewed, cut, or otherwise damaged. These natural chemicals most likely contribute to plant defence against pests and diseases, and impart a characteristic bitter flavor property to cruciferous vegetables.
Plant defense against herbivory or host-plant resistance (HPR) describes a range of adaptations evolved by plants which improve their survival and reproduction by reducing the impact of herbivores. Plants can sense being touched, and they can use several strategies to defend against damage caused by herbivores. Many plants produce secondary metabolites, known as allelochemicals, that influence the behavior, growth, or survival of herbivores. These chemical defenses can act as repellents or toxins to herbivores or reduce plant digestibility. Another defensive strategy of plants is changing their attractiveness. To prevent overconsumption by large herbivores, plants alter their appearance by changing their size or quality, overall decreasing their consumption rate.
Herbivores are dependent on plants for food, and have coevolved mechanisms to obtain this food despite the evolution of a diverse arsenal of plant defenses against herbivory. Herbivore adaptations to plant defense have been likened to "offensive traits" and consist of those traits that allow for increased feeding and use of a host. Plants, on the other hand, protect their resources for use in growth and reproduction, by limiting the ability of herbivores to eat them. Relationships between herbivores and their host plants often results in reciprocal evolutionary change. When a herbivore eats a plant it selects for plants that can mount a defensive response, whether the response is incorporated biochemically or physically, or induced as a counterattack. In cases where this relationship demonstrates "specificity", and "reciprocity", the species are thought to have coevolved. The escape and radiation mechanisms for coevolution, presents the idea that adaptations in herbivores and their host plants, has been the driving force behind speciation. The coevolution that occurs between plants and herbivores that ultimately results in the speciation of both can be further explained by the Red Queen hypothesis. This hypothesis states that competitive success and failure evolve back and forth through organizational learning. The act of an organism facing competition with another organism ultimately leads to an increase in the organism's performance due to selection. This increase in competitive success then forces the competing organism to increase its performance through selection as well, thus creating an "arms race" between the two species. Herbivores evolve due to plant defenses because plants must increase their competitive performance first due to herbivore competitive success.
Barbarea vulgaris, also called wintercress, or alternatively herb barbara, rocketcress, yellow rocketcress, winter rocket, yellow rocket, and wound rocket, is a biennial herb of the genus Barbarea, belonging to the family Brassicaceae.
The Max Planck Institute for Chemical Ecology is located on Beutenberg Campus in Jena, Germany. It was founded in March 1996 and is one of 80 institutes of the Max Planck Society. Chemical ecology examines the role of chemical signals that mediate the interactions between plants, animals, and their environment, as well as the evolutionary and behavioral consequences of these interactions. The managing director of the institute is Jonathan Gershenzon.
Myrosinase is a family of enzymes involved in plant defense against herbivores, specifically the mustard oil bomb. The three-dimensional structure has been elucidated and is available in the PDB.
Plant use of endophytic fungi in defense occurs when endophytic fungi, which live symbiotically with the majority of plants by entering their cells, are utilized as an indirect defense against herbivores. In exchange for carbohydrate energy resources, the fungus provides benefits to the plant which can include increased water or nutrient uptake and protection from phytophagous insects, birds or mammals. Once associated, the fungi alter nutrient content of the plant and enhance or begin production of secondary metabolites. The change in chemical composition acts to deter herbivory by insects, grazing by ungulates and/or oviposition by adult insects. Endophyte-mediated defense can also be effective against pathogens and non-herbivory damage.
Bill S. Hansson is a Swedish neuroethologist. From June 2014 until June 2020, he was vice president of the Max Planck Society.
Wilhelm Boland is a German chemist.
Ian Thomas Baldwin is an American ecologist.
David G. Heckel is an American entomologist.
Methionine transaminase is an enzyme with systematic name L-methionine:2-oxo-acid aminotransferase. This enzyme catalyses the following chemical reaction
(E)-β-Ocimene synthase is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase ( -β-ocimene-forming). This enzyme catalyses the following chemical reaction
The mustard oil bomb, formerly known as the glucosinolate–myrosinase complex, is a chemical herbivory defense system found in members of the Brassicaceae. The mustard oil bomb requires the activation of a common plant secondary metabolite, glucosinolate, by an enzyme, myrosinase. The defense complex is typical among plant defenses to herbivory in that the two molecules are stored in different compartments in the leaves of plants until the leaf is torn by an herbivore. The glucosinolate has a β-glucose and a sulfated oxime. The myrosinase removes the β-glucose to form mustard oils that are toxic to herbivores. The defense system was named a "bomb" by Matile, because it like a real bomb is waiting to detonate upon disturbance of the plant tissue.
Elizabeth S. Sattely is an American scientist and biotechnology engineer. She is an Associate Professor of Chemical Engineering in the Department of Chemical Engineering, an HHMI investigator, and a ChEM-H Faculty Fellow at Stanford University.
Joseph Jez is a Howard Hughes Medical Institute Professor and Spencer T. Olin Professor of Biology at Washington University in St. Louis. He has served as the Chair of the Washington University Biology Department since 2018. His research focuses on the effect of environmental changes on biochemical pathways in plants, aiming to apply this research to present-day agricultural and environmental issues.
Webpage of the Department of Biochemistry at the Max Planck Institute for Chemical Ecology
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