Jonathan Daniel Wren | |
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Alma mater | University of Texas Southwestern Medical Center, University of Oklahoma |
Known for | data mining, genetics |
Scientific career | |
Institutions | Oklahoma Medical Research Foundation |
Thesis | The IRIDESCENT System: An Automated Data-Mining Method to Identify, Evaluate, and Analyze Sets of Relationships Within Textual Databases (2003) |
Doctoral advisor | Harold Garner |
Jonathan D. Wren is a scientific investigator at the Oklahoma Medical Research Foundation [1] in the Department of Arthritis and Clinical Immunology, and an Adjunct Assistant Professor in the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center. [2]
Wren received his Ph.D. in Genetics and Development at the University of Texas Southwestern Medical Center in 2003, [3] and immediately after began his independent research career at the University of Oklahoma. [4] He moved to OMRF in 2007. His bioinformatics research focuses on developing computational methods of inferring logical conclusions from extremely large bodies of unstructured or semi-structured measurements and/or facts. [5] He has been recognized for his work in text mining, [6] studies on URL decay (link rot) in scientific publications, [7] plagiarism detection [8] and for discovering the function of uncharacterized human genes. [9] Wren is an Associate Editor for the journal Bioinformatics.
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH). It is approved and funded by the government of the United States. The NCBI is located in Bethesda, Maryland, and was founded in 1988 through legislation sponsored by US Congressman Claude Pepper.
Biomedical text mining refers to the methods and study of how text mining may be applied to texts and literature of the biomedical domain. As a field of research, biomedical text mining incorporates ideas from natural language processing, bioinformatics, medical informatics and computational linguistics. The strategies in this field have been applied to the biomedical literature available through services such as PubMed.
David J. Lipman is an American biologist who from 1989 to 2017 was the director of the National Center for Biotechnology Information (NCBI) at the National Institutes of Health. NCBI is the home of GenBank, the U.S. node of the International Sequence Database Consortium, and PubMed, one of the most heavily used sites in the world for the search and retrieval of biomedical information. Lipman is one of the original authors of the BLAST sequence alignment program, and a respected figure in bioinformatics. In 2017, he left NCBI and became Chief Science Officer at Impossible Foods.
Mark Bender Gerstein is an American scientist working in bioinformatics and Data Science. As of 2009, he is co-director of the Yale Computational Biology and Bioinformatics program.
Europe PubMed Central is an open-access repository that contains millions of biomedical research works. It was known as UK PubMed Central until 1 November 2012.
Karen B. Avraham is an Israeli-American human geneticist and the first female Dean of the Tel Aviv University's Faculty of Medicine. Born in Canada in 1962, Avraham moved to the US at a young age. Her research focuses on the discovery and characterization of genes responsible for hereditary hearing loss.
The Comparative Toxicogenomics Database (CTD) is a public website and research tool launched in November 2004 that curates scientific data describing relationships between chemicals/drugs, genes/proteins, diseases, taxa, phenotypes, GO annotations, pathways, and interaction modules. The database is maintained by the Department of Biological Sciences at North Carolina State University.
Lawrence E. Hunter is a Professor and Director of the Center for Computational Pharmacology and of the Computational Bioscience Program at the University of Colorado School of Medicine and Professor of Computer Science at the University of Colorado Boulder. He is an internationally known scholar, focused on computational biology, knowledge-driven extraction of information from the primary biomedical literature, the semantic integration of knowledge resources in molecular biology, and the use of knowledge in the analysis of high-throughput data, as well as for his foundational work in computational biology, which led to the genesis of the major professional organization in the field and two international conferences.
Iroquois-class homeodomain protein IRX-1, also known as Iroquois homeobox protein 1, is a protein that in humans is encoded by the IRX1 gene. All members of the Iroquois (IRO) family of proteins share two highly conserved features, encoding both a homeodomain and a characteristic IRO sequence motif. Members of this family are known to play numerous roles in early embryo patterning. IRX1 has also been shown to act as a tumor suppressor gene in several forms of cancer.
Pavel Arkadevich Pevzner is the Ronald R. Taylor Professor of Computer Science and director of the NIH Center for Computational Mass Spectrometry at University of California, San Diego. He serves on the editorial board of PLoS Computational Biology and he is a member of the Genome Institute of Singapore scientific advisory board.
Lynne Elizabeth Maquat is an American biochemist and molecular biologist whose research focuses on the cellular mechanisms of human disease. She is an elected member of the American Academy of Arts and Sciences, the National Academy of Sciences and the National Academy of Medicine. She currently holds the J. Lowell Orbison Endowed Chair and is a professor of biochemistry and biophysics, pediatrics and of oncology at the University of Rochester Medical Center. Professor Maquat is also Founding Director of the Center for RNA Biology and Founding Chair of Graduate Women in Science at the University of Rochester.
Alfonso Valencia is a Spanish biologist, ICREA Professor, current director of the Life Sciences department at Barcelona Supercomputing Center., of Spanish National Bioinformatics Institute (INB-ISCIII), and coordinator of the data pillar of the Spanish Personalised Medicine initiative, IMPaCT. From 2015-2018, he was President of the International Society for Computational Biology.
Cathy H. Wu is the Edward G. Jefferson Chair and professor and director of the Center for Bioinformatics & Computational Biology (CBCB) at the University of Delaware. She is also the director of the Protein Information Resource (PIR) and the North east Bioinformatics Collaborative Steering Committee, and the adjunct professor at the Georgetown University Medical Center.
Christine Anne Orengo is a Professor of Bioinformatics at University College London (UCL) known for her work on protein structure, particularly the CATH database. Orengo serves as president of the International Society for Computational Biology (ISCB), the first woman to do so in the history of the society.
Sandhya Srikant Visweswariah is a scientist and academic at the Indian Institute of Science, Bangalore, India. She was the Chairperson of the Department of Developmental Biology and Genetics and the Co-chair of the Department of Bioengineering, Indian Institute of Science. She additionally holds the position of Adjunct Professor, Faculty of Medicine and Dentistry, University of Bergen, Norway. Her research involves the investigation of the mechanism of signal transduction via cyclic nucleotides, phosphodiesterases and novel cyclases in bacteria. Most recently, she was awarded a Bill and Melinda Gates Grand Challenges Explorations Grant for her proposal entitled "A Small Animal Model of ETEC-Mediated Diarrhea".
Alok Bhattacharya is an Indian parasitologist, academic and a professor at the School of Life Sciences of the Jawaharlal Nehru University. He chairs the Biotechnology Information System Network (BITSNET) as well as the Life Sciences Expert Committee of FIST program of the Department of Science and Technology (DST). He is an elected fellow of the Indian Academy of Sciences and the Indian National Science Academy and is known for his studies on Entamoeba histolytica and species-specific calcium binding protein and its gene.
Yagya Dutta Sharma is an Indian molecular biologist, professor and head of the department of biotechnology at the All India Institute of Medical Sciences, Delhi. An elected fellow of all three major Indian science academies — Indian National Science Academy, Indian Academy of Sciences, and National Academy of Sciences, India — Sharma is known for his research on the molecular biology of malaria. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology for his contributions to medical sciences in 1994.
Alexander Stark is a biochemist and computational biologist working on the regulation of gene expression in development. He is a senior scientist at the Research Institute of Molecular Pathology (IMP) at the Vienna Biocenter and adjunct professor of the Medical University of Vienna.
Eriko Takano is a professor of synthetic biology and a director of the Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM) at the University of Manchester. She develops antibiotics and other high-value chemicals using microbial synthetic biology tools.
CCDC188 or coiled-coil domain containing protein is a protein that in humans is encoded by the CCDC188 gene.