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VIB is a research institute located in Flanders, Belgium. It was founded by the Flemish government in 1995, and became a full-fledged institute on 1 January 1996. The main objective of VIB is to strengthen the excellence of Flemish life sciences research and to turn the results into new economic growth. VIB spends almost 80% of its budget on research activities, while almost 12% is spent on technology transfer activities and stimulating the creation of new businesses, in addition VIB spends approximately 2% on socio-economic activities. VIB is member of EU-LIFE, an alliance of leading life sciences research centres in Europe.
Désiré, Baron Collen is a Belgian physician, chemist, biotechnology entrepreneur and life science investor. He made several discoveries in thrombosis, haemostasis and vascular biology in many of which serendipity played a significant role. His main achievement has been his role in the development of tissue-type plasminogen activator (t-PA) from a laboratory concept to a life-saving drug for dissolving blood clots causing acute myocardial infarction or acute ischemic stroke. Recombinant t-PA was produced and marketed by Genentech Inc as Activase and by Boehringer Ingelheim GmbH as Actilyse, and is considered biotechnology's first life saving drug.
Jean-Christophe Marine is a Belgian molecular biologist and researcher at CME Ku-Leuven (Belgium). He is head of the VIB Laboratory of Molecular Cancer Biology. His research interest is in the identification and characterization of cancer growth modulators, such as p53.
Frederic Rousseau is a Flemish Belgian molecular biologist and researcher at the KU Leuven. Together with Joost Schymkowitz he is group leader at the VIB Switch Laboratory, KU Leuven. His research interest is on essential cellular processes where functional regulation is governed by protein conformational switches that have to be actively controlled to ensure cell viability
Bart De Strooper is a Belgian molecular biologist and professor at Vlaams Instituut voor Biotechnologie and KU Leuven and the UK Dementia Research Institute and University College London, UK. De Strooper's research seeks to translate genetic data into the identification and treatment of neurodegenerative diseases and treatments. interest are the secretases, proteases which cleave the amyloid precursor protein (APP), resulting in amyloid peptides.
Patrick Callaerts is a Belgian molecular biologist and researcher at the Katholieke Universiteit Leuven. He is head of the VIB Laboratory of Developmental Genetics, KU Leuven.
Johan Thevelein is a Belgian molecular biologist and professor at the Katholieke Universiteit Leuven. He is head of the VIB Department of Molecular Biology, KU Leuven.
The VIB Switch laboratory, Katholieke Universiteit Leuven is a department of VIB located at the Katholieke Universiteit Leuven in Leuven, Belgium. The laboratory is headed by Frederic Rousseau and Joost Schymkowitz.
Arthur Mallay Lesk, is a protein science researcher, who is a professor of biochemistry and molecular biology at the Pennsylvania State University in University Park.
BriX is a database containing some protein fragments from 4 to 14 residue from non-homologous proteins.
Steven Elliot Brenner is a professor at the Department of Plant and Microbial Biology at the University of California Berkeley, adjunct professor at the Department of Bioengineering and Therapeutic Sciences at the University of California, and San Francisco Faculty scientist, Physical Biosciences at the Lawrence Berkeley National Laboratory.
David Barford is a British medical researcher and structural biologist at the MRC Laboratory of Molecular Biology Cambridge, UK.
Sarah Amalia Teichmann is a German scientist, the former head of cellular genetics at the Wellcome Sanger Institute and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI). She serves as director of research in the Cavendish Laboratory, Professor at the University of Cambridge and Cambridge Stem Cell Institute, and is a senior research fellow at Churchill College, Cambridge.
Diether Lambrechts is a Belgian geneticist and professor at the KU Leuven and VIB. He is the director of the Vesalius Research Center. Lambrechts is known for his multidisciplinary approach to dissecting tumor biology. Major scientific contributions include identifying oxygen supply regulation as an anti-cancer treatment strategy.
Alexandru Radu Aricescu, known by his middle name, is a Romanian-British molecular neuroscientist based at the MRC Laboratory of Molecular Biology, Cambridge; Prior to 2017, he worked at the Wellcome Trust Centre for Human Genetics at the University of Oxford; in 2016 the University awarded him the title of Professor of Molecular Neuroscience.
Sjors Hendrik Willem ScheresFRS is a Dutch scientist at the MRC Laboratory of Molecular Biology Cambridge, UK.
Anne Bertolotti is a French biochemist and cell biologist who works as Programme Leader at the MRC Laboratory of Molecular Biology in Cambridge, UK. In 2022 she was appointed Head of the MRC LMB's Neurobiology Division. She is known for her research into the cellular defences against misfolded proteins and the mechanisms underlying their deposition, the molecular problem causative of neurodegenerative diseases.
Computational methods that use protein sequence and/ or protein structure to predict protein aggregation. The table below, shows the main features of software for prediction of protein aggregation
Wolfgang P. Baumeister is a German molecular biologist and biophysicist. His research has been pivotal in the development of Cryoelectron tomography.
Stein Aerts is a Belgian bio-engineer and computational biologist. He leads the Laboratory of Computational Biology at VIB and KU Leuven, and is director of VIB.AI, the VIB Center for AI & Computational Biology. He has received several accolades for his research into the workings of the genomic regulatory code.
References
- ↑ A systems biology perspective on protein structural dynamics and signal transduction, Rousseau F, Schymkowitz J, Curr Opin Struct Biol 23-30, 2005
