The VIB Switch laboratory, Katholieke Universiteit Leuven is a department of VIB located at the Katholieke Universiteit Leuven in Leuven, Belgium. The laboratory is headed by Frederic Rousseau and Joost Schymkowitz.
VIB is a research institute located in Flanders, Belgium. VIB was founded by the Flemish government in 1995, and became a full-fledged institute on 1 January 1996. The main objective of VIB is to strengthen the excellence of Flemish life sciences research and to turn the results into new economic growth. VIB spends almost 80% of its budget on research activities, while almost 12% is spent on technology transfer activities and stimulating the creation of new businesses, in addition VIB spends approximately 2% on socio-economic activities.
Leuven or Louvain is the capital of the province of Flemish Brabant in Belgium. It is located about 25 kilometres east of Brussels. The municipality itself comprises the historic city and the former neighbouring municipalities of Heverlee, Kessel-Lo, a part of Korbeek-Lo, Wilsele and Wijgmaal. It is the eighth largest city in Belgium and the fourth in Flanders with more than 100,244 inhabitants.
Belgium, officially the Kingdom of Belgium, is a sovereign state in Western Europe. It is bordered by the Netherlands to the north, Germany to the east, Luxembourg to the southeast, France to the southwest, and the North Sea to the northwest. It covers an area of 30,688 km2 (11,849 sq mi) and has a population of more than 11.4 million. The capital and largest city is Brussels; other major cities are Antwerp, Ghent, Charleroi and Liège.
Its research focuses on functional regulation of cellular processes, which are governed by protein conformational switches that have to be actively controlled to ensure cell viability. The laboratory combines in vitro biophysical techniques and computational structural biology methods with advanced cell biological studies.
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.
Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules how they acquire the structures they have, and how alterations in their structures affect their function. This subject is of great interest to biologists because macromolecules carry out most of the functions of cells, and it is only by coiling into specific three-dimensional shapes that they are able to perform these functions. This architecture, the "tertiary structure" of molecules, depends in a complicated way on each molecule's basic composition, or "primary structure."
