| Discipline | Oncology |
|---|---|
| Language | English |
| Publication details | |
| History | 2002-present |
| Publisher | |
| Frequency | Quarterly |
| Standard abbreviations | |
| ISO 4 | J. Carcinog. |
| Indexing | |
| ISSN | 0974-6773 (print) 1477-3163 (web) |
| Links | |
The Journal of Carcinogenesis is a peer-reviewed open access medical journal published by Medknow Publications on behalf of the Carcinogenesis Press. The journal covers research in oncology.
The journal is abstracted and indexed in: Abstracts on Hygiene and Communicable Diseases, CAB Abstracts, EBSCO databases, Excerpta Medica/EMBASE, Expanded Academic ASAP, Pubmed Central, and Scopus.
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A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis. This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive substances are considered carcinogens, but their carcinogenic activity is attributed to the radiation, for example gamma rays and alpha particles, which they emit. Common examples of non-radioactive carcinogens are inhaled asbestos, certain dioxins, and tobacco smoke. Although the public generally associates carcinogenicity with synthetic chemicals, it is equally likely to arise from both natural and synthetic substances. Carcinogens are not necessarily immediately toxic; thus, their effect can be insidious.
An abstract is a brief summary of a research article, thesis, review, conference proceeding, or any in-depth analysis of a particular subject and is often used to help the reader quickly ascertain the paper's purpose. When used, an abstract always appears at the beginning of a manuscript or typescript, acting as the point-of-entry for any given academic paper or patent application. Abstracting and indexing services for various academic disciplines are aimed at compiling a body of literature for that particular subject.
Genotoxicity is the property of chemical agents that damage the genetic information within a cell causing mutations, which may lead to cancer. While genotoxicity is often confused with mutagenicity, all mutagens are genotoxic, but some genotoxic substances are not mutagenic. The alteration can have direct or indirect effects on the DNA: the induction of mutations, mistimed event activation, and direct DNA damage leading to mutations. The permanent, heritable changes can affect either somatic cells of the organism or germ cells to be passed on to future generations. Cells prevent expression of the genotoxic mutation by either DNA repair or apoptosis; however, the damage may not always be fixed leading to mutagenesis.
Nitrofurazone is an antimicrobial organic compound belonging to the nitrofuran class. It is most commonly used as a topical antibiotic ointment. It is effective against gram-positive bacteria, gram-negative bacteria, and can be used in the treatment of trypanosomiasis. Its use in medicine has become less frequent, as safer and more effective products have become available. Nitrofurazone is listed under California Prop 65, and has demonstrated clear evidence to be mutagenic and carcinogenic during animal studies, and has been discontinued for human use in the USA. The substance is pale yellow and crystalline. It was once widely used as an antibiotic for livestock.
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. Normally, the balance between proliferation and programmed cell death, in the form of apoptosis, is maintained to ensure the integrity of tissues and organs. According to the prevailing accepted theory of carcinogenesis, the somatic mutation theory, mutations in DNA and epimutations that lead to cancer disrupt these orderly processes by interfering with the programming regulating the processes, upsetting the normal balance between proliferation and cell death. This results in uncontrolled cell division and the evolution of those cells by natural selection in the body. Only certain mutations lead to cancer whereas the majority of mutations do not.
The American Association for Cancer Research (AACR) is the world's oldest and largest professional association related to cancer research. Based in Philadelphia, the AACR focuses on all aspects of cancer research, including basic, clinical, and translational research into the etiology, prevention, diagnosis, and treatment of cancer. Founded in 1907 by 11 physicians and scientists, the organization now has more than 52,000 members in 130 countries and territories. The mission of the AACR is to prevent and cure cancer through research, education, communication, collaboration, science policy and advocacy, and funding for cancer research.
Propyl gallate, or propyl 3,4,5-trihydroxybenzoate is an ester formed by the condensation of gallic acid and propanol. Since 1948, this antioxidant has been added to foods containing oils and fats to prevent oxidation. As a food additive, it is used under the E number E310.
Carveol is a natural unsaturated, monocyclic monoterpenoid alcohol that is a constituent of spearmint essential oil in the form of cis-(−)-carveol. It is a colorless fluid soluble in oils, but insoluble in water and has an odor and flavor that resemble those of spearmint and caraway. Consequently, it is used as a fragrance in cosmetics and as a flavor additive in the food industry.
tert-Butylhydroquinone is a synthetic aromatic organic compound which is a type of phenol. It is a derivative of hydroquinone, substituted with a tert-butyl group.
α-Eleostearic acid or (9Z,11E,13E)-octadeca-9,11,13-trienoic acid, is an organic compound, a conjugated fatty acid and one of the isomers of octadecatrienoic acid. It is often called simply eleostearic acid although there is also a β-eleostearic acid. Its high degree of unsaturation gives tung oil its properties as a drying oil.
8-Oxoguanine glycosylase, also known as OGG1, is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene. It is involved in base excision repair. It is found in bacterial, archaeal and eukaryotic species.
Cancer bacteria are bacteria infectious organisms that are known or suspected to cause cancer. While cancer-associated bacteria have long been considered to be opportunistic, there is some evidence that bacteria may be directly carcinogenic. The strongest evidence to date involves the bacterium H. pylori and its role in gastric cancer.
KRT76 is a keratin gene. Loss of this gene's expression or downregulation of the gene is associated with oral cancer.
Carcinogenesis is a peer-reviewed medical journal in the field of cancer biology. It was established in 1980 and is published monthly by Oxford University Press. As of 2010, the editor-in-chief is Curtis C. Harris. Carcinogenesis publishes articles in four sections: cancer biology covers the cell and molecular biology of cancer, as well as mutation and DNA repair; molecular epidemiology includes genetic predisposition to cancer; cancer prevention covers chemoprophylaxis as well as dietary factors; and carcinogenesis covers all forms of carcinogens, including their metabolism and detection in the environment. Authors can pay to have their articles released freely online as part of a hybrid open access scheme. Free or reduced-rate online access is available to educational institutions in low-income countries.
Cancer cells are cells that divide continually, forming solid tumors or flooding the blood or lymph with abnormal cells. Cell division is a normal process used by the body for growth and repair. A parent cell divides to form two daughter cells, and these daughter cells are used to build new tissue or to replace cells that have died because of aging or damage. Healthy cells stop dividing when there is no longer a need for more daughter cells, but cancer cells continue to produce copies. They are also able to spread from one part of the body to another in a process known as metastasis.
Bucetin is an analgesic and antipyretic that is no longer marketed. Chemically, it is similar to phenacetin with which it shares the risk of carcinogenesis. Bucetin was withdrawn from use in 1986 due to renal toxicity.
Toxicological Sciences is a monthly peer-reviewed scientific journal which covers all aspects of research on toxicology. It is published by Oxford University Press on behalf of the Society of Toxicology. It was established in 1981 as Fundamental and Applied Toxicology and obtained its current name in 1998. The current editor-in-chief is Jeffrey M. Peters, a professor of molecular toxicology and carcinogenesis at The Pennsylvania State University, and the Managing Editor is Virginia F. Hawkins. The editorial staff also includes Associate Editors in subject areas and an editorial board of topic experts. While its ISO 4 abbreviation is Toxicol. Sci. it is commonly referred to as ToxSci.
Naftalan or Naphtalan is a type of crude oil. It is named after Naftalan, Azerbaijan, where it is found. It is known for its high naphthalene content and use in alternative medicine.
Izrael Hieger DSc (London) was a biochemist whose work focused on carcinogenesis. He discovered the first known organic carcinogenic compound. In 1937 Hieger, with colleagues Ernest Kennaway and J. W. Cook, was nominated for a Nobel Prize for work on isolating chemical carcinogenic agents from tar and studies on the relation between chemical constitution and carcinogenic activity.
The Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews is a biannual peer-reviewed scientific journal covering environmental health as it relates to carcinogenesis and toxicology. It was established in 1976 and is published by Taylor & Francis. The editor-in-chief is Peter P. Fu. According to the Journal Citation Reports, the journal has a 2015 impact factor of 3.667.
