Jukka Jernvall (born 1963) is a Finnish evolutionary biologist in the field of evo-devo research. [1] His research has centered on the interplay of ecology, evolution and developmental biology, especially of the mammalian dentition. Jernvall is currently an Academy Professor [2] at the Institute of Biotechnology, University of Helsinki. [3]
Jernvall received his Ph.D. in evolutionary biology in 1995. His thesis investigating the evolution and development of mammalian molar cusp patterns was supervised by Irma Thesleff and Mikael Fortelius. This led to the description of enamel knot as molecular signaling centers in teeth. He also discovered and coined the term ‘secondary enamel knot’, previously overlooked signaling centers regulating tooth cusp development. This discovery helped to mechanistically link molecular regulation of growth and differentiation to shape. Later, Jernvall has focused on the modelling of three-dimensional dentition phenotypes. He has studied why certain dentition patterns arise several times during the course of evolution, while other patterns occur only rarely. Jernvall's team has developed several methods from computer modeling of organ development to three-dimensional analysis of biological shape development and function. [4] Current research ranges from mutant mice in the laboratory to evolutionary diversity in the fossil record and to seal genomics.
Biology – The natural science that studies life. Areas of focus include structure, function, growth, origin, evolution, distribution, and taxonomy.
Carnivora is a monophyletic order of placental mammals consisting of the most recent common ancestor of all cat-like and dog-like animals, and all descendants of that ancestor. Members of this group are formally referred to as carnivorans, and have evolved to specialize in eating flesh. The order is the fifth largest order of mammals, comprising at least 279 species.
Xenarthra is a major clade of placental mammals native to the Americas. There are 31 living species: the anteaters, tree sloths, and armadillos. Extinct xenarthrans include the glyptodonts, pampatheres and ground sloths. Xenarthrans originated in South America during the late Paleocene about 60 million years ago. They evolved and diversified extensively in South America during the continent's long period of isolation in the early to mid Cenozoic Era. They spread to the Antilles by the early Miocene and, starting about 3 Mya, spread to Central and North America as part of the Great American Interchange. Nearly all of the formerly abundant megafaunal xenarthrans became extinct at the end of the Pleistocene.
Evolutionary developmental biology is a field of biological research that compares the developmental processes of different organisms to infer how developmental processes evolved.
Dentition pertains to the development of teeth and their arrangement in the mouth. In particular, it is the characteristic arrangement, kind, and number of teeth in a given species at a given age. That is, the number, type, and morpho-physiology of the teeth of an animal.
The molars or molar teeth are large, flat teeth at the back of the mouth. They are more developed in mammals. They are used primarily to grind food during chewing. The name molar derives from Latin, molaris dens, meaning "millstone tooth", from mola, millstone and dens, tooth. Molars show a great deal of diversity in size and shape across mammal groups. The third molar of humans is sometimes vestigial.
Modelling biological systems is a significant task of systems biology and mathematical biology. Computational systems biology aims to develop and use efficient algorithms, data structures, visualization and communication tools with the goal of computer modelling of biological systems. It involves the use of computer simulations of biological systems, including cellular subsystems, to both analyze and visualize the complex connections of these cellular processes.
Tooth development or odontogenesis is the complex process by which teeth form from embryonic cells, grow, and erupt into the mouth. For human teeth to have a healthy oral environment, all parts of the tooth must develop during appropriate stages of fetal development. Primary (baby) teeth start to form between the sixth and eighth week of prenatal development, and permanent teeth begin to form in the twentieth week. If teeth do not start to develop at or near these times, they will not develop at all, resulting in hypodontia or anodontia.
Neontology is a part of biology that, in contrast to paleontology, deals with living organisms. It is the study of extant taxa : taxa with members still alive, as opposed to (all) being extinct. For example:
In tooth development, the enamel knot is a localization of cells on an enamel organ that appear thickened in the center of the inner enamel epithelium. The enamel knot is frequently associated with an enamel cord. It is formed in the cap stage and undergoes apoptosis in the bell stage.
A polyphyodont is any animal whose teeth are continually replaced. In contrast, diphyodonts are characterized by having only two successive sets of teeth.
Tooth development or odontogenesis is the process in which teeth develop and grow into the mouth. Tooth development varies among species.
A cusp is a pointed, projecting, or elevated feature. In animals, it is usually used to refer to raised points on the crowns of teeth.
Kuehneotherium is an early mammaliaform genus, previously considered a holothere, that lived during the Late Triassic-Early Jurassic Epochs and is characterized by reversed-triangle pattern of molar cusps. Although many fossils have been found, the fossils are limited to teeth, dental fragments, and mandible fragments. The genus includes Kuehneotherium praecursoris and all related species. It was first named and described by Doris M. Kermack, K. A. Kermack, and Frances Mussett in November 1967. The family Kuehneotheriidae and the genus Kuehneotherium were created to house the single species Kuehneotherium praecursoris. Modeling based upon a comparison of the Kuehneotherium jaw with other mammaliaforms indicates it was about the size of a modern-day shrew between 4 and 5.5 g at adulthood.
Many different terms have been proposed for features of the tooth crown in mammals.
The Turing pattern is a concept introduced by English mathematician Alan Turing in a 1952 paper titled "The Chemical Basis of Morphogenesis" which describes how patterns in nature, such as stripes and spots, can arise naturally and autonomously from a homogeneous, uniform state.
Cheek teeth or post-canines comprise the molar and premolar teeth in mammals. Cheek teeth are multicuspidate. Mammals have multicuspidate molars and premolars situated between canines and molars whose shape and number varies considerably among particular groups. For example, many modern Carnivora possess carnassials, or secodont teeth. This scissor-like pairing of the last upper premolar and first lower molar is adapted for shearing meat. In contrast, the cheek teeth of deer and cattle are selenodont. Viewed from the side, these teeth have a series of triangular cusps or ridges, enabling the ruminants' sideways jaw motions to break down tough vegetable matter. Cheek teeth are sometimes separated from the incisors by a gap called a diastema.
The following outline is provided as an overview of and topical guide to evolution:
Narayanaswamy Srinivasan was an Indian molecular biophysicist and a professor and the head of Proteins: Structure, Function and Evolutionary Group at the Molecular Biophysics Unit of the Indian Institute of Science. He is known for his researches in the fields of computational genomics and protein structure analysis. An elected fellow of the Indian Academy of Sciences and the National Academy of Sciences, India, he is a J. C. Bose National fellow of the Department of Biotechnology and a recipient of the National Bioscience Award for Career Development of the Department of Science and Technology. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2007, for his contributions to biological sciences.
Irma Thesleff is a Professor Emerita at the University of Helsinki known for her research on the development of mammalian organs, especially tooth development.