Keokee is an unincorporated community and census-designated place (CDP) in Lee County, Virginia, United States. The population was 416 at the 2010 census.
U.S. Route 119 (US 119) is a spur of US 19. It is a north–south route that was an original United States highway of 1926. It is Corridor G of the Appalachian Development Highway System (ADHS) east of US 23 and KY 80 in Kentucky to Interstate 64 at Charleston, West Virginia.
State Route 68 is a primary state highway in the U.S. state of Virginia. Known for most of its length as Exeter Road, the state highway runs 6.13 miles (9.87 km) from the Lee–Wise county line near Keokee, where the highway continues west as SR 606, east to U.S. Route 23 Business in Appalachia.
State Route 38 is a primary state highway in the U.S. state of Virginia. Known for most of its length as Five Forks Road, SR 38 runs 7.03 miles (11.31 km) from U.S. Route 360 Business in Amelia Court House east to SR 153 at Scotts Fork.
Kentucky Route 160, also known as KY 160, is a state highway in the U.S. state of Kentucky. It runs from the Virginia state line, where the roadway continues east to Appalachia, Virginia as State Route 160, north via Lynch, Benham, Clutts, Cumberland, Sand Hill, Gordon, Linefork, Kings Creek, Premium, and Hot Spot to Kentucky Route 15 at Van. KY 160 overlaps KY 15 through Isom to Cody, where it splits to run via Carr Creek, Brinkley, and Hindman, ending at Kentucky Route 1087 at Vest. Due to the mountainous terrain and numerous tight bends. KY 160 is signposted closed to tractor-trailers from Lynch to the Virginia state line.
Kentucky Route 194 (KY 194) is an 85.945-mile-long (138.315 km) state highway in Kentucky that runs from Kentucky Route 1428 east of Emma to Virginia State Route 697 at the Virginia state line south of Argo via Woods, Kimper, Phyllis, Phelps, Freeburn, Majestic, and Stopover.
Kentucky Route 40 (KY 40) is a 42.339-mile-long (68.138 km) state highway in the U.S. state of Kentucky. The highway begins at an intersection with US 460/KY 7 in Salyersville, within Magoffin County, then continues eastward through Paintsville, within Johnson County. KY 40 ends in Martin County at an intersection with KY 292 and an access bridge to US 52 at the West Virginia state line.
U.S. Route 421 (US 421) in the U.S. state of Kentucky is a 250.536-mile-long (403.199 km) north–south United States highway that traverses twelve counties in the central and eastern parts of the state. It travels in a southeast-to-northwest path from the Virginia state line near Pennington Gap to the Indiana state line, on the Ohio River at Milton, Kentucky and Madison, Indiana.
Kentucky Route 251 (KY 251) is an 11-mile-long (18 km) state highway in the U.S. state of Kentucky, split into two sections. The highway connects Elizabethtown and Fort Knox with rural areas of Hardin County; the second section, separated from the first by Fort Knox, is near Belmont in Bullitt County.
Kentucky Route 3041 (KY 3041) is a state highway in the southeastern part of the U.S. state of Kentucky. Known as the Corbin Bypass, the route runs 5.700 miles (9.173 km) from U.S. Route 25W east and north to US 25E within Corbin. KY 3041 provides a southeastern bypass of the center of Corbin through eastern Whitley County and western Knox County. The bypass was planned starting in the late 1980s and was constructed in three stages in the mid-1990s. KY 3041 eased congestion in downtown Corbin and stimulated educational and industrial development in the late 1990s.
US 421 in Harlan 
SR 624 near Keokee, VA 
