Kim Sung-hoon (biologist)

Last updated
Sunghoon Kim
Born1958 (age 66–67)
South Korea
Alma materPh.D. Brown University, U.S.
Known forAminoacyl-tRNA Synthetases
Awards Korea Science Award, Ministry of Science and Technology (2003)
Scientist of the Month, Korea Science and Engineering Foundation (KOSEF) (2003)
Top Scientist and Technologist Award of Korea, Ministry of Science and Technology (2006)
Award of Korean National Academy of Science (2012)
Scientific career
FieldsAminoacyl-tRNA synthetase, Translation, Cancer biology, Therapeutic target discovery
Institutions Seoul National University
Doctoral advisor Dr. Arthur Landy
Korean name
Hangul
김성훈
Revised Romanization Gim Seonghun
McCune–Reischauer Kim Sŏnghun

Dr. Kim Sunghoon is a South Korean biologist.

Education

Work

Dr. Sunghoon Kim has been studying novel functions of human aminoacyl-tRNA synthetases (ARSs) and searching for their pathophysiological connections to human diseases (PNAS 105:11043, [1] 2008; Nat Rev Cancer 11:708, 2011 [2] ). He has identified potent novel tumor suppressors such as AIMP2/p38 (Nat Genet 34:330, 2003 [3] ), AIMP3/p18 (Cell, 120:209, 2005 [4] ). Besides, he has also investigated novel extracellular activities of ARSs and associated factors such as lysyl-tRNA synthetase (KRS) (PNAS 102, 6356, 2005 [5] ), tryptophanyl-tRNA synthetase(WRS)(Nat Struct Mol Biol 11:149, 2004 [6] ) and AIMP1/p43 (PNAS 103:14913, 2006 [7] ). He also discovered the oncogenic variant of AIMP2, designated AIMP2-DX2, as one of the critical factors that determines the survival of lung cancer patients (Plos Genet 7:e1001351, 2011 [8] ). More recently[ when? ], he found that leucyl-tRNA synthetase (LRS) serves as an amino acid sensor for mTOR signal pathway (Cell 149:410, 2012 [9] ).

Contents

Awards

See also

References

  1. ↑ Aminoacyl tRNA synthetases and their connections to disease
  2. ↑ Kim, Sunghoon; You, Sungyong; Hwang, Daehee (2011). "Aminoacyl-tRNA synthetases and tumorigenesis: More than housekeeping" . Nature Reviews Cancer. 11 (10): 708–718. doi:10.1038/nrc3124. PMID   21941282. S2CID   44712015.
  3. ↑ Kim, Min Jung; Park, Bum-Joon; Kang, Young-Sun; Kim, Hyoung June; Park, Jae-Hyun; Kang, Jung Woo; Lee, Sang Won; Han, Jung Min; Lee, Han-Woong; Kim, Sunghoon (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation" . Nature Genetics. 34 (3): 330–336. doi:10.1038/ng1182. PMID   12819782. S2CID   41006480.
  4. ↑ Cell - The Haploinsufficient Tumor Suppressor p18 Upregulates p53 via Interactions with ATM/ATR
  5. ↑ Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response
  6. ↑ Kise, Yoshiaki; Lee, Sang Won; Park, Sang Gyu; Fukai, Shuya; Sengoku, Toru; Ishii, Ryohei; Yokoyama, Shigeyuki; Kim, Sunghoon; Nureki, Osamu (2004). "A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase" . Nature Structural & Molecular Biology. 11 (2): 149–156. doi:10.1038/nsmb722. PMID   14730354. S2CID   20084521.
  7. ↑ Hormonal activity of AIMP1/p43 for glucose homeostasis
  8. ↑ PLOS Genetics: Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis
  9. ↑ Cell - Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
  10. ↑ "KOFST 한국과학기술단체총연합회". Archived from the original on 2013-06-16. Retrieved 2013-06-10.
  11. ↑ "NAS Award : Activities : The National Academy Of Sciences Republic Of Korea". Archived from the original on 2013-12-07. Retrieved 2013-06-10.
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