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Recurrent miscarriage or recurrent pregnancy loss (RPL) is the spontaneous loss of 2-3 pregnancies that is estimated to affect up to 5% of women. The exact number of pregnancy losses and gestational weeks used to define RPL differs among medical societies. In the majority of cases, the exact cause of pregnancy loss is unexplained despite genetic testing and a thorough evaluation. When a cause for RPL is identified, almost half are attributed to a chromosomal abnormality. RPL has been associated with several risk factors including parental and genetic factors, congenital and acquired anatomical conditions, lifestyle factors, endocrine disorders, thrombophila, immunological factors, and infections. The American Society of Reproductive Medicine recommends a thorough evaluation after 2 consecutive pregnancy losses; however, this can differ from recommendations by other medical societies. RPL evaluation can be evaluated by numerous tests and imaging studies depending on the risk factors. These range from cytogenetic studies, blood tests for clotting disorders, hormone levels, diabetes screening, thyroid function tests, sperm analysis, antibody testing, and imaging studies. Treatment is typically tailored to the relevant risk factors and test findings. RPL can have a significant impact on the psychological well-being of couples and has been associated with higher levels of depression, anxiety, and stress. Therefore, it is recommended that appropriate screening and management be considered by medical providers.
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References
- ↑ Li, Qian H.; Lagakos, Stephen W. (April 1997), "Use of The Wei–Lin–Weissfeld method for the analysis of a recurring and a terminating event", Statistics in Medicine, 16 (8): 925–940, doi:10.1002/(sici)1097-0258(19970430)16:8<925::aid-sim545>3.0.co;2-2, PMID 9160489
- ↑ Metcalfe, Chris; Thompson, Simon G. (April 2007), "Wei, Lin and Weissfeld's marginal analysis of multivariate failure time data: should it be applied to a recurrent events outcome?", Statistical Methods in Medical Research, 16 (2): 103–122, doi:10.1177/0962280206071926, hdl: 1983/0c15aeee-0913-4eca-a5cc-05e7211e2f53 , PMID 17484295
- ↑ Lisa Weissfeld at the Mathematics Genealogy Project
- 1 2 3 "Weissfelds say goodbye to Pitt" (PDF), Epidemiology Newsletter, p. 2, March 2015, retrieved 2023-04-24
- ↑ "History", Risk Analysis Section, American Statistical Association, retrieved 2023-04-24
- ↑ "Section officers, 1997", Risk Analysis Section, American Statistical Association, retrieved 2023-04-24
- ↑ "Library", Committee of Presidents of Statistical Societies, American Statistical Association, retrieved 2023-04-24
- ↑ Fellows, American Statistical Association, retrieved 2023-04-24
