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 Artur Jorge (2001–02) -
 Francisco Maturana (2002) -
 Ilie Balaci (2002–03) -
 Aad de Mos (2003–04) -
 Ahmed Alajlani (2004) -
 Marcos Paquetá (July 1, 2004–Dec 19, 2005, Mar 31, 2007–May 30, 2007) - Jose Kléber (Mar 24, 2006–May 28, 2006)
- José Peseiro (May 29, 2006–Jan 8, 2007)
- Toninho Cerezo (Jan 30, 2007–Mar 29, 2007)
- Cosmin Olăroiu (July 1, 2007–Feb 28, 2009)
- Catalin Necula (interim) (Feb 28, 2009–Mar 19, 2009)
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 Georges Leekens (Apr 1, 2009–May 3, 2009) - Eric Gerets (Jul 1, 2009–Nov 13, 2010)
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 Gabriel Calderon (Nov 14, 2010–June 30, 2011) -
 Thomas Doll (July 22, 2011–Jan 20, 2012) - Heiko Bonan (interim) (Jan 21, 2012–Jan 30, 2012)
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 Ivan Hašek (Jan 31, 2012–June 26, 2012) -
 Antoine Kombouaré (June 27, 2012–Jan 30, 2013) -
 Zlatko Dalić (Jan 31, 2013–May 27, 2013) -
 Sami Al-Jaber (May 28, 2013–May 26, 2014) - Laurențiu Reghecampf (May 27, 2014–Feb 15, 2015)
- Marius Ciprian (interim) (Feb 16, 2015–Feb 28, 2015)
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 Giorgos Donis (Mar 1, 2015–May 18, 2016) - Abdullatif Al-Hussaini (interim) (May 18, 2016–Jun 11, 2016)
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 Gustavo Matosas (Jun 12, 2016–Sep 22, 2016) - Marius Ciprian (interim) (Sep 22, 2016–Oct 15, 2016)
- Ramón Díaz (Oct 15, 2016–Feb 21, 2018)
- Juan Brown (interim) (Feb 21, 2018–Jun 1, 2018)
- Jorge Jesus (Jun 5, 2018–Jan 31, 2019,
- Zoran Mamić (Jan 31, 2019–Apr 27, 2019)
- Péricles Chamusca (Apr 27, 2019–Jun 30, 2019)
- Razvan Lucescu (Jun 30, 2019–Feb 14, 2021)
- Rogério Micale (Feb 14, 2021–May 3 2021)
- Leonardo Jardim (June 2, 2021–Feb 14 2022)
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