| Interstate Highways in Maine | |
|---|---|
  Standard markers for Interstate Highways in Maine | |
 Interstate Highways highlighted in red | |
| System information | |
| Maintained by MaineDOT | |
| Formed | June 29, 1957 |
| Highway names | |
| Interstates | Interstate x (I-X) |
| US Highways | U.S. Route x (US-X) |
| State | State Route x or Route x (SR X) |
| System links | |
Note about termini: In several cases there is disagreement between the administrative termini of a route (which is defined by MaineDOT) and the termini signed in the field. All termini listed on this page are administrative termini; discrepancies are listed on the respective pages.
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 I-95 | 303.2 | 488.0 | I-95 in Portsmouth, NH | Route 95 in Woodstock, NB (Houlton–Woodstock Border Crossing) | 1956 | current | Realigned in 2004, former toll-free alignment designated I-295 | |
 I-195 | 1.55 | 2.49 | I-95 | SR 5 | 1982 | current | ||
 I-295 | 53.61 | 86.28 | I-95 | I-95 | 1956 | current | Extended in 2004, alignment north of the Falmouth Spur was originally I-95 | |
 I-395 | 5.00 | 8.05 | I-95/SR 15 | US 1A | 1959 | current | ||
 I-495 | — | — | I-95 | I-95 | 1988 | 2004 | Former designation of the Maine Turnpike north of the Falmouth Spur, redesignated I-95 in 2004 | |
| I-495 | 4.41 | 7.10 | I-95 (Maine Turnpike) | US 1 | 2004 | current | Unsigned, formerly I-95 prior to 2004 renumbering; known as the Falmouth Spur | |
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